A5081477645- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Abdominal Surgery and Complications
- Hepatitis B Virus Studies
- Gynecological conditions and treatments
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Intestinal and Peritoneal Adhesions
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
- Clinical Nutrition and Gastroenterology
Centro di Riferimento Oncologico
2012-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
National Cancer Institute
2012
Gynecologic Oncology Group
2012
Magna Graecia University
2007
Platinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, little is known about how acquisition of PT-resistance mediates increased spreading capabilities EOC. Here, using isogenic cells, genetic pharmacological approaches, patient-derived models, we report that Integrin α6 (ITGA6) overexpressed by cells necessary to sustain ability adhesion-dependent...
Probe-based confocal laser endomicroscopy (pCLE) is a novel real-time imaging technique that potentially useful for accurately distinguishing between normal and cancerous tissues. The aim of this study was to describe the pCLE patterns areas suggestive tumors evaluate ability method differentiate tissue during cytoreductive surgery epithelial ovarian cancer. In vivo images subsequent biopsies were acquired from various anatomical sites including parietal visceral peritoneum, ovaries,...
The objective of this study was to give a reality-based picture the use laparoscopic surgery for staging endometrial cancer patients out experimental setting.Consecutive data with who underwent or abdominal surgical in 6 Italian centers were recorded. Baseline and tumors characteristics, performed, safety collected analyzed.A total 1012 subjects (403 609 treated by laparoscopy laparotomy, respectively) received stadiation included final analysis. approach more commonly performed younger...
Abstract The CDKN1B gene, encoding for the CDK inhibitor p27 kip1 , is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. Lessons learned from tumors suggest that mutations could be subclonal, raising question of whether a deeper sequencing approach lead to identification higher numbers patients with mutations. Here, we addressed this analyzed biopsies breast ( n = 396), ovarian 110) head neck squamous carcinoma 202)...
Optimal debulking surgery is postulated to be useful in survival of ovarian cancer patients. Some studies highlighted the possible role bowel this topic. We wanted evaluate involvement patients with advanced epithelial who underwent optimal cytoreduction.Between 1997 and 2004, 301 at Department Gynecological Oncology Centro di Riferimento Oncologico (CRO) National Cancer Institute Aviano (PN) Italy. All maximal surgical effort, including upper abdominal procedure, order achieve (R < 0.5 cm)....
PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian cancer tumors deficient the homologous recombination (HR) pathway treated platinum (Pt)-based therapy. PARPi exert their cytotoxic effect by both trapping PARP1 on damaged DNA and restraining its enzymatic activity (PARylation). How is recruited trapped at damage sites how resistance to could be overcome are still matters of investigation. Here, we described as substrate deubiquitinase USP1. At molecular...
OBIECTIVE: This study aimed to evaluate the safety of conservative treatment in women desiring preservation fertility with stage IA adenocarcinoma cervix.Clinical report all cervix, endocervical subtype, clear margins on cone biopsy, diagnosed our cancer center inclusive between January 1995 and December 2007, were evaluated, after either therapy or hysterectomy. All diagnoses reviewed by a pathologist expert gynecologic oncology. Follow-up methods include at least cervical cytology,...
Objectives: The objectives of this study were to evaluate whether the international recommendations on management uterine papillary serous carcinoma arising in a polyp are uniformly followed Italian Oncologic Centers and strategy adopted is effective. Materials Methods: Patients with who had undergone hysterectomy identified 2003-2013 database 7 Gynecologic Oncology Centers. Clinical pathologic characteristics outcomes compared between staging procedure types. Survival curves women plotted...
Aim: High levels of TS have been associated with a worse clinical outcome in several cancers including epithelial ovarian cancer (EOC). The gene (TYMS) is highly polymorphic and has an effect on mRNA/protein expression. Materials & methods: Six TYMS polymorphisms were investigated for overall survival (OS) 216 EOC patients: 1494ins/del, TSER (variable number tandem repeats 28 bp), G>C, 1053C>T, IVS6-68C>T 1122A>G. Results: In multivariate analysis, 1494 del/del genotype was significant...
Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as new paradigm in particular patients microsatellites instability/mismatch repair deficiency. case report, we describe an exceptional and rapid response dostarlimab platinum refractory patient high disease burden harboring mismatch