A5079447202- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Phytochemicals and Antioxidant Activities
- Edible Oils Quality and Analysis
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Hops Chemistry and Applications
- Hormonal and reproductive studies
- Tannin, Tannase and Anticancer Activities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
Azienda Sanitaria Unità Locale di Reggio Emilia
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Tecnologie Avanzate (Italy)
2016-2022
Weatherford College
2022
Istituto Superiore di Sanità
2022
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2018
Ospedale Santa Maria
2013-2017
Candiolo Cancer Institute
2016
University of Turin
2016
MultiMedica
2015
Aberrant reactivation of embryonic pathways is a common feature cancer. RUNX2 transcription factor crucial during embryogenesis that aberrantly reactivated in many tumors, including thyroid and breast cancer, where it promotes aggressiveness metastatic spreading. Currently, the mechanisms driving expression cancer are still largely unknown. Here we showed requires cooperation three distantly located enhancers (ENHs) brought together by chromatin three-dimensional looping. We BRD4 controls...
Abstract Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local metastatic growth in preclinical models. Since is frequently used along with Aspirin or beta-blockers, we investigated the effect of Metformin, beta-blocker Atenolol several In vitro , synergized inducing triple negative endocrine-sensitive cells activating AMPK white adipose tissue (WAT) progenitors known to cooperate progression. Both added inhibitory against complex I respiratory chain. both...
Abstract Background Triple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types cancers in the faster spread and worse outcome. TNBC presented limited treatment options. BET (Bromodomain extra-terminal domain) proteins are epigenetic readers control expression different oncogenic proteins, their inhibition (BETi) considered promising anti-cancer strategy. Recent evidence demonstrated involvement regulation metabolic processes. Methods MDA-MB231 cells...
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is crucial step in tumor growth and dissemination. Recently, increased attention has been addressed to ability flavonoids prevent cancer suppressing angiogenesis, strategy that we named "angioprevention". Several natural compounds exert their anti-tumor properties activating 5' adenosine monophosphate-activated protein kinase (AMPK), key regulator metabolism cells. Drugs with angiopreventive...
The NEDD8 conjugation pathway modulates the ubiquitination and activity of a wide range intracellular proteins, its blockade by pevonedistat is emerging as promising therapeutic approach in various cancer settings. However, systematic characterization efficacy specific tumor types definition response predictors are still missing.We investigated vitro sensitivity to 122 colorectal (CRC) cell lines an ATP-based proliferation assay evaluated apoptosis DNA content flow cytometry. Associations...
Abstract Neoadjuvant chemotherapy (NAC) alone or combined with target therapies represents the standard of care for localized triple-negative breast cancer (TNBC). However, only a fraction patients have response, necessitating better understanding complex elements in TNBC ecosystem that establish continuous and multidimensional interactions. Resolving such complexity requires new spatially-defined approaches. Here, we used spatial transcriptomics to investigate organization at diagnosis...
Repressing BET proteins' function using bromodomain inhibitors (BETi) has been shown to elicit antitumor effects by regulating the transcription of genes downstream BRD4. We previously showed that BETi promoted cell death triple-negative breast cancer (TNBC) cells. Here, we proved induce altered mitochondrial dynamics fitness in TNBC cells falling death. demonstrated treatment downregulated expression BCL-2, and proteins involved fission increased fused mitochondria. Impaired affected...
Assessment of biological diagnostic factors providing clinically-relevant information to guide physician decision-making are still needed for diseases with poor outcomes, such as non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) is a promising molecule in the clinical management NSCLC. While EGFR transmembrane form has been extensively investigated large trials, soluble, circulating isoform (sEGFR), which may have potential use, rarely considered. This study...
Abstract Enhancer (ENH)-associated long noncoding RNAs (lncRNA) are a peculiar class of produced by transcriptionally active ENHs, owning potential gene-regulatory function. Here, we characterized RAIN, novel ENH-associated lncRNA. Analysis RAIN expression in retrospective cohort human thyroid cancers showed that the this lncRNA is restricted to cancer cells and strongly correlates with cancer-promoting transcription factor RUNX2. We serving as cis-regulatory element, promotes RUNX2 two...
BRD4 is an epigenome reader known to exert key roles at the interface between chromatin remodeling and transcriptional regulation, primarily for its role in promoting gene expression. In selective contexts, however, may work as negative regulator of transcription. Here, we reported that binds several long noncoding RNAs (lncRNA). Among these, lncRNA NEAT1 was found interfere with activity. Mechanistically, lncNEAT1 forms a complex WDR5 maintains them low-activity state. Treatment...
Analyzing gene expression profiles (GEP) through artificial intelligence provides meaningful insight into cancer disease. This study introduces DeepSHAP Autoencoder Filter for Genes Selection (DSAF-GS), a novel deep learning and explainable intelligence-based approach feature selection in genomics-scale data. DSAF-GS exploits the autoencoder's reconstruction capabilities without changing original space, enhancing interpretation of results. Explainable is then used to select informative genes...
While the anti-tumor effects of phenolic compounds are largely studied [22], little is known about their anti-angiogenic and angiopreventive potential referred as ability to target angiogenesis in cancer prevention [23].Angiogenesis, formation new blood vessels from preexisting vasculature, essential for many physiological processes, such embryogenesis, also plays a critical role pathological conditions, including cancer.This process an event tumor growth crucial hallmark progression...
ABSTRACT Therapy‐related acute promyelocytic leukemia (t‐APL) is rare and often linked to previous treatment with alkylating agents or topoisomerase II inhibitors. This report describes three cases of t‐APL treated at the Haematology Department Cosenza Hospital between 2022 2024, which occurred after exemestane, radiation therapy, agents, taxane, checkpoint inhibitor, respectively. Each case was managed a different therapeutic approach. The first involved 71‐year‐old man colorectal breast...
The NOTCH signaling is an evolutionarily conserved pathway that regulates cell-cell interactions. family members play a fundamental role in variety of processes during development particular cell fate decisions. As other crucial factors embryogenesis, aberrantly reactivated cancer where it has been linked to context-dependent effects. In thyroid cancer, NOTCH1 expression associated aggressive features even if its vivo within the entire spectrum tumors not definitively established. A series...
Abstract The BAP1 tumor suppressor gene encodes a deubiquitinase enzyme involved in several cellular activities, including DNA repair and apoptosis. Germline pathogenic variants have been associated with heritable conditions predisposition syndrome 1 (BAP1‐TPDS1) neurodevelopmental disorder known as Kury‐Isidor (KURIS). Both these are caused by monoallelic, dominant alterations of but never reported the same subject or family, suggesting mutually exclusive genotype–phenotype correlation....