A5107301137- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Mesenchymal stem cell research
- Hops Chemistry and Applications
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Edible Oils Quality and Analysis
- Bone and Dental Protein Studies
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Pleural and Pulmonary Diseases
- Phytochemicals and Antioxidant Activities
- PI3K/AKT/mTOR signaling in cancer
- Tannin, Tannase and Anticancer Activities
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
MultiMedica
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Fondazione IRCCS Istituto Nazionale dei Tumori
2019-2024
Milano Metropoli Development Agency
2024
University of Insubria
2015-2019
NK cells are effector lymphocytes involved in tumor immunosurveillance; however, patients with solid malignancies, have compromised functions. We previously reported that lung tumor-associated (TANKs; peripheral blood) and tumor-infiltrating (TINKs) show proangiogenic, decidual NK-like (dNK) phenotype. In this study, we functionally molecularly investigated TINKs TANKs from blood tissue samples of colorectal cancer (CRC), a neoplasm which inflammation angiogenesis clinical relevance,...
The stromal and immune bone marrow (BM) landscape is emerging as a crucial determinant for acute myeloid leukemia (AML). Regulatory T cells (Treg) are enriched in the AML microenvironment, but underlying mechanisms poorly elucidated. Here, we addressed effect of IFNγ released by BM Treg induction its impact on prognosis.BM aspirates from patients with were subdivided according to IFNG expression. Gene expression profiles INFγhigh IFNγlow samples compared microarray NanoString analysis used...
Matrix metalloproteinases (MMPs) have been shown to be involved in tumor-induced angiogenesis. In particular, MMP-2, MMP-9, and MMP-14 reported crucial for tumor angiogenesis the formation of metastasis, thus becoming attractive targets cancer therapy. Here, we report our optimization effort identify novel N-isopropoxy-arylsulfonamide hydroxamates with improved inhibitory activity toward respect previously discovered compound 1. A new series was designed, synthesized, tested their...
Natural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired cancer patients, becoming poorly cytotoxic. A particular type of NK cells, from the decidua, has low cytotoxicity shows proangiogenic functions. We investigated whether peripheral blood (PB) pleural effusions patients develop decidual-like phenotype exposure to IL-2 can restore killing ability presence fluids. effusion with inflammatory conditions (iPE, n = 18), primary (ptPE,...
Highlights•ZEB1+ AML blasts are immune regulatory via Th17 expansion•IL-17 promotes proliferation and invasion of ZEB1+ cells•IL-17 ZEB1 binding to target gene promoters•ZEB1 blast features combine regulation chemoresistanceSummaryAcute myeloid leukemia (AML) progression is influenced by suppression induced cells. ZEB1, a critical transcription factor in epithelial-to-mesenchymal transition, demonstrates functions AML. Silencing leukemic cells reduces engraftment extramedullary disease...
Abstract Background Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dental Pulp stem cells (DPSC), due their easy biological access, ex vivo properties, and ability support angiogenesis have been largely explored in regenerative medicine. Methods Here, we tested the capability Stem Cell-Conditioned medium (DPSC-CM), produced normoxic (DPSC-CM Normox) or hypoxic Hypox) conditions, via soluble factors. CMs were characterized...
Abstract: Carbon nanotubes (CNTs) have been extensively investigated and employed for industrial use because of their peculiar physical properties, which make them ideal many applications. However, rapid growth CNT employment raises concerns about the potential risks toxicities public health, environment, workers associated with manufacture these new materials. Here we investigate main routes entry following environmental exposure to multi-wall CNTs (MWCNTs; currently most widely used in...
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is crucial step in tumor growth and dissemination. Recently, increased attention has been addressed to ability flavonoids prevent cancer suppressing angiogenesis, strategy that we named "angioprevention". Several natural compounds exert their anti-tumor properties activating 5' adenosine monophosphate-activated protein kinase (AMPK), key regulator metabolism cells. Drugs with angiopreventive...
Carnitines play an important role in the energy exchange cells, and are involved transport of fatty acids across inner mitochondrial membrane. l-Acetylcarnitine (ALCAR) is acetic acid ester carnitine that has higher bioavailability considered a fat-burning energizer supplement. We previously found serum samples from prostate cancer (PCa) patients, 3 family members were significantly decreased, suggesting potential protective against PCa. Several studies support beneficial effects carnitines...
Medulloblastoma (MB), a neuroectodermal tumor arising in the cerebellum, represents most frequent childhood brain malignancy. Current treatments for MB combine radiation and chemotherapy are often associated with relevant side effects; novel therapeutic strategies urgently needed. N-(4-Hydroxyphenyl) retinamide (4-HPR, fenretinide), synthetic analogue of all-trans retinoic acid, has emerged as promising well-tolerated cancer chemopreventive chemotherapeutic agent various neoplasms, from...
Summary Activated human neutrophils produce a fibrillar DNA network [neutrophil extracellular traps (NETs)] for entrapping and killing bacteria, fungi, protozoa viruses. Our results suggest that the neutrophil show resistant amyloidogenic backbone utilized addressing reputed proteins against non-self. The formation of amyloid fibrils in is regulated by imbalance reactive oxygen species (ROS) cytoplasm. intensity source ROS signal determinant promoting stress-associated responses such as...
Neutrophil extracellular traps (NETs) are web-like chromatin structures composed by dsDNA and histones, decorated with antimicrobial proteins. Their interaction dendritic cells (DCs) allows DC activation maturation toward presentation of NET-associated antigens. Differently from other types cell death that imply protein denaturation, NETosis preserves the proteins localized onto DNA threads for proper enzymatic activity conformational status, including immunogenic epitopes. Besides...
The secreted protein acidic and rich in cysteine (SPARC) is a matricellular with unexpected immunosuppressive function myeloid cells. We investigated the role of SPARC autoimmunity using pristane-induced model lupus that, mice, mimics human systemic erythematosus (SLE). Sparc-/- mice developed earlier more severe renal disease, multi-organ parenchymal damage, arthritis than wild-type counterpart. Sparc+/- heterozygous showed an intermediate phenotype suggesting Sparc gene dosage...
Cancer is a systemic disease able to reprogram the bone marrow (BM) niche towards protumorigenic state. The impact of cancer on specific BM subpopulations can qualitatively differ according signals released by tumor, which vary basis tissue origin. Using spontaneous model mammary carcinoma, we identified mesenchymal stem cells (MSC) as first sensors distal and key mediators reprogramming. Through release IL1B, MSCs induced transcriptional upregulation nuclear translocation activating...