A5082065845- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Medicinal Plant Pharmacodynamics Research
- Ovarian function and disorders
- Ginseng Biological Effects and Applications
- Phytoestrogen effects and research
- Complementary and Alternative Medicine Studies
- Phytochemistry and biological activity of medicinal plants
- Pharmacological Effects of Natural Compounds
- Health Systems, Economic Evaluations, Quality of Life
- Plant-based Medicinal Research
- Bioactive Compounds and Antitumor Agents
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Phytochemistry and Bioactive Compounds
- Knee injuries and reconstruction techniques
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Resilience and Mental Health
- Delphi Technique in Research
- Health, psychology, and well-being
- Meta-analysis and systematic reviews
- Reproductive Biology and Fertility
- Cytokine Signaling Pathways and Interactions
- Biomedical Ethics and Regulation
Goethe University Frankfurt
2009
Clinical Research Services
2006-2008
Background: The 3-dimensional autologous chondrocyte transplantation (ACT3D) comprises isolation of chondrocytes from cartilage biopsies, cultivation to spheroids, and into the defect. Objectives: To evaluate patients’ general health functionality assess defect repair after ACT3D with spheroids by MRI MOCART scoring. Methods: Thirty-seven patients isolated chondral lesions knee underwent through medial arthrotomy. Patient-administered scores were assessed at baseline (day before...
To investigate the efficacy and safety of special extract ERr 731 from roots Rheum rhaponticum compared to placebo in perimenopausal women with climacteric complaints.A multicenter, prospective, randomized, double-blind, placebo-controlled, clinical trial which 109 complaints received either one enteric-coated tablet (n = 54) or 55) daily for 12 weeks. Primary outcome criterion was change Menopause Rating Scale II (MRS II) total score after Other assessments analyzed number severity hot...
In Brief Objective: To investigate the long-term efficacy and safety of ERr 731 in perimenopausal women with menopausal symptoms. Design: This was a multicenter, prospective, 48-week observational study (OS) (OS I) followed by OS II symptoms taking 731. Of 109 participating previous randomized, placebo-controlled trial (RCT), 39 receiving 41 placebo participated I. Fifty-one continued to take (23 from group 28 group). The primary outcome criterion for change Menopause Rating Scale score...
Current guidelines for certain cancer therapies mainly provide recommendations therapy options treating the primary tumors. However, first-choice treatments advanced or metastasizing tumors are described only rarely if at all. In such cases, one more individual treatment chosen by physician depending on medical need of patient and considering acceptance this patient. Often, well-known drugs selected with a different dosing than is indicated in drug information leaflet. other not yet approved...
To investigate the efficacy of special extract ERr 731 from roots Rheum rhaponticum compared with placebo on anxiety, health state, and general well-being in perimenopausal women.This study is a multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial, which 109 women climacteric complaints anxiety received either 1 enteric coated tablet (n=54) or (n=55) daily for 12 weeks. The Hamilton Anxiety Scale, Menopause Rating Scale II, Women's Health Questionnaire,...
Objectives: Arnica montana, belonging to the Compositae family, is a plant with longstanding tradition of relieving pain and/or inflammation in muscles and joints may thus represent an alternative nonsteroidal antiinflammatory drugs, which are often ineffective or lead number adverse effects. A homeopathic arnica patch (3X dilution according Homeopathic Pharmacopoeia United States) was developed alleviate symptoms back neck joints. Case Presentation: The present case report describes...
For the safe use of medicinal products, it is important that physicians publish adverse experiences with a product-particularly regarding side effects-in scientific literature. However, when searching applicable publications, we determined drug reactions (ADRs) are often published several months after their occurrence. In context patient safety, this rather questionable as new and information on ADRs not available quickly enough to be considered in pharmacovigilance systems. This delay also...
The special extract ERr 731® from the roots of Rheum rhaponticum L. is major constituent Phyto-Strol which has been used for relief menopausal symptoms decades. We recently demonstrated nearly pure estrogen receptor-β (ERβ) agonistic properties in human endometrial and bone cell systems. Here we present investigations on effects uterine growth proliferation ovariectomized (OvEx) rats following subcutaneous treatment 72h with therapeutic dose (0.1mg/kg body weight (bw)/day), a pharmacological...
Perimenopause is the time until last menstruation, when women experience irregular menstruation and climacteric symptoms.
The special extract ERr 731® from the roots of Rheum rhaponticum is major constituent Phytoestrol® N which has been used for treatment climacteric symptoms decades. However, molecular mode action underlying its proven clinical efficacy not completely clarified. Therefore, we addressed question whether and aglycones trans-rhapontigenin desoxyrhapontigenin exert their biological via estrogen receptor-alpha -beta (ERa, ERb). effects were compared to structurally related compounds...
Background . Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, information on the use resources; (2) provide for clinical research practice guidelines, (3) inform medical education. High-quality are more likely when authors follow reporting guidelines. During 2011–2012, a group clinicians, researchers, journal editors developed recommendations accurate in that resulted CARE (CAse REport) Statement Checklist. They were presented at 2013...
Der Extrakt ERr 731 aus der Rhapontikrhabarberwurzel wird bei Menopausenbeschwerden eingesetzt. Zwei placebokontrollierte Doppelblindstudien mit perimenopausalen Frauen belegen eine signifikante Reduktion Beschwerden. Beobachtungsstudien zeigen keine Endometriumhyperplasie oder Zunahme Brustdichte. Wirksamkeit und Verträglichkeit wurden in einer Anwendungsbeobachtung bestätigt. Sicherheit im Endometrium menopausalen Beschwerden können durch die preferenzielle Aktivierung des...