A5059364953- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Vitamin C and Antioxidants Research
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Acne and Rosacea Treatments and Effects
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Reproductive System and Pregnancy
- Adipokines, Inflammation, and Metabolic Diseases
- Biotin and Related Studies
- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Vitamin K Research Studies
- Phagocytosis and Immune Regulation
- Cancer, Lipids, and Metabolism
- melanin and skin pigmentation
- Vitamin D Research Studies
- Drug Transport and Resistance Mechanisms
- Nutrition, Genetics, and Disease
- Adrenal Hormones and Disorders
- Eicosanoids and Hypertension Pharmacology
VOCO (Germany)
2023
University of Debrecen
2013-2022
Inserm
2018
Université de Strasbourg
2018
Centre National de la Recherche Scientifique
2018
Faculty (United Kingdom)
2018
Hungarian Academy of Sciences
2008-2017
Heidelberg University
2016
Universidade de Vigo
2016
Ludwig-Maximilians-Universität München
2016
Dendritic cells (DCs) expressing CD1d, a molecule responsible for lipid antigen presentation, are capable of enhancing natural killer T (iNKT) cell proliferation. The signals controlling CD1 expression and presentation poorly defined. We have shown previously that stimulation the lipid-activated transcription factor, peroxisome proliferator-activated receptor (PPAR)γ, indirectly regulates CD1d expression. Here we demonstrate PPARγ, turns on retinoic acid synthesis by inducing retinol retinal...
The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling variety (patho)-physiological processes. Although synthetic RXR ligands developed for the treatment various diseases, endogenous ligand(s) these have not been conclusively identified. We show here that mice lacking cellular retinol binding protein (Rbp1-/-) display memory deficits reflecting compromised signaling. Using HPLC-MS and...
Abstract 9‐ cis ‐Retinoic acid was identified and claimed to be the endogenous ligand of retinoid X receptors (RXRs) in 1992. Since then, presence this compound has never been rigorously confirmed. Instead, concerns have raised by other groups that reported ‐retinoic is undetectable or its occurs at very low levels. Furthermore, these levels could not satisfactorily explain physiological activation RXR. Alternative ligands, among them various lipids, also identified, but did fulfill criteria...
As lipids are known to regulate macrophage functions, it is reasonable suppose that a sebocyte-macrophage axis mediated by sebum may exist.To investigate if sebocytes could contribute the differentiation, polarization and function of macrophages with their secreted lipids.Oil Red O lipid staining Raman spectroscopy were used assess dermal content penetration. Immunohistochemistry was analyse subsets. Human peripheral blood monocytes differentiated in presence either supernatant from human...
In addition to producing sebum, sebocytes link lipid metabolism with inflammation at a cellular level and hence, greatly resemble adipocytes. However, so far no analysis was performed identify characterize the adipocyte-associated inflammatory proteins, members of adipokine family in sebocytes. Therefore, we determined expression profile adipokines [adiponectin, interleukin (IL) 6, resistin, leptin, serpin E1, visfatin, apelin, chemerin, retinol-binding protein 4 (RBP4) monocyte...
Cholesterol uptake and efflux are key metabolic processes associated with macrophage physiology atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARγ) liver X alpha (LXRα) have been linked to the regulation of these processes. It remains be identified how activation receptors is connected regulated by endogenous lipid molecules. We CYP27, a p450 enzyme, as link between retinoid, PPARγ, LXR signaling. show that human CYP27 gene under coupled retinoids ligands PPARs via...
The increasing prevalence of atopic eczema has been linked to the alteration Western diet, namely reduced consumption omega-3 (n-3) polyunsaturated fatty acids (PUFA) and an increased omega-6 (n-6) PUFA intake.The aim pilot study was determine efficacy dietary n-3 docosahexaenoic acid (DHA) in patients with eczema.Fifty-three suffering from aged 18-40 years were recruited into this randomized, double-blind, controlled trial received either DHA 5.4 g daily (n = 21) or isoenergetic control...
Aggressive periodontitis (AgP) is a rapidly progressing type of periodontal disease in otherwise healthy individuals which causes destruction the supporting tissues teeth. The initiated by pathogenic bacteria dental biofilm, and severity inflammation attachment loss varies with host response. Recently, there has been an increased interest determining role lipid mediators inflammatory events concept pro-inflammatory pro-resolution brought into focus also disease. present study aimed to...
Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear and also act as homodimers. Heterodimers formed by RXR a nonpermissive partner, e.g. retinoic acid receptor (RAR) vitamin D (VDR), can be activated only the agonist of partner receptor. In contrast, heterodimers that contain permissive partners, liver (LXR) peroxisome proliferator-activated (PPAR), agonists either or RXR, raising possibility pleiotropic signaling. However, it is not known to what extent receptor's...
Adiponectin is an adipocyte-derived adipokine with potent antidiabetic, anti-inflammatory, and antiatherogenic activity. Long-term, high-fat diet results in gain of bodyweight, adiposity, further inflammatory-based cardiovascular diseases, reduced adiponectin secretion. VitaminAderivatives/retinoids are involved several these processes, which mainly take place inwhite adipose tissue (WAT). In this study, we examined expression as a function dietary high–vitamin A conditions mice. decrease...
Abstract Retinoic acid isomers, 4‐oxo‐retinoic isomers and retinol are present in the serum of mammals. In this study a high‐performance liquid chromatography (HPLC) separation, sample preparation tandem mass spectrometry (MS/MS) method was established for quick easy sensitive determination retinoids such as all‐ trans ‐4‐oxo‐retinoic acid, 13‐ cis ‐retinoic 9‐ cell extracts. Serum samples were simply treated with three times volume isopropanol, dried under vacuum, taken up HPLC solvent...
Two new secoiridoid glucosides, excelsides A (1) and B (2), were isolated from the seeds of Fraxinus excelsior. Their structures elucidated as (2S,4S,3E)-methyl 3-ethylidene-4-(2-methoxy-2-oxoethyl)-2-[(6-O-β-d-glucopyranosyl-β-d-glucopyranosyl)oxy]-3,4-dihydro-2H-pyran-5-carboxylate 3-ethylidene-4-{2-[2-(4-hydroxyphenyl)ethyl]oxy-2-oxoethyl}-2-[(6-O-β-d-glucopyranosyl-β-d-glucopyranosyl)oxy]-3,4-dihydro-2H-pyran-5-carboxylate, respectively, on basis NMR MS data. Eight known compounds...