A5108021976- Antimicrobial Peptides and Activities
- Inflammatory mediators and NSAID effects
- Diabetes and associated disorders
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Drug-Induced Adverse Reactions
- Diagnosis and treatment of tuberculosis
- Bone Metabolism and Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Tuberculosis Research and Epidemiology
- Oral microbiology and periodontitis research
- Dementia and Cognitive Impairment Research
- Parasites and Host Interactions
- Dysphagia Assessment and Management
- Magnesium in Health and Disease
- Biomedical Research and Pathophysiology
- Parathyroid Disorders and Treatments
- Reproductive System and Pregnancy
- Wnt/β-catenin signaling in development and cancer
- Oral health in cancer treatment
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- NF-κB Signaling Pathways
- Diabetic Foot Ulcer Assessment and Management
- Oral and gingival health research
Thomas Jefferson University
2024
Al Jalila Foundation
2022-2024
Badr University in Cairo
2024
Western Norway University of Applied Sciences
2022-2024
Mohammed Bin Rashid University of Medicine and Health Sciences
2022
Assiut University
2022
Latifa Hospital
2014-2021
Dubai Health Authority
2021
University of Bergen
2012-2013
Karolinska Institutet
2003-2004
Aggressive periodontitis (AgP) is a rapidly progressing type of periodontal disease in otherwise healthy individuals which causes destruction the supporting tissues teeth. The initiated by pathogenic bacteria dental biofilm, and severity inflammation attachment loss varies with host response. Recently, there has been an increased interest determining role lipid mediators inflammatory events concept pro-inflammatory pro-resolution brought into focus also disease. present study aimed to...
Glucose-induced insulin release is decreased in the spontaneously diabetic GK rat, a nonobese rodent model of type 2 diabetes. Forskolin restores impaired both isolated perfused pancreas and islets from these rats (Abdel-Halim et al., Diabetes 45:934-940, 1996). We demonstrate here that insulinotropic effect forskolin rat due to increased generation cAMP it associated with overexpression adenylyl cyclase (AC)-III mRNA gene mutations. The AC-III was demonstrated by situ hybridization using...
X-linked hypophosphatemia (XLH) is a rare inherited cause of hypophosphatemic rickets and osteomalacia. It caused by mutations in the phosphate-regulating endopeptidase homolog, (PHEX). This results increased plasma fibroblast growth factor-23 (FGF23), which leads to loss renal sodium-phosphate co-transporter expression leading chronic phosphate excretion. also low serum 1,25-dihydroxyvitamin D (1,25(OH)2D), resulting impaired intestinal absorption. Chronic XLH endochondral mineralization...
The aim of this study was to explore the utility inflammatory biomarkers in peripheral blood predict response treatment extrapulmonary tuberculosis (EPTB). A Luminex xMAP-based multiplex immunoassay used measure 40 un-stimulated plasma 91 EPTB patients (48 lymphadenitis, and 43 pleuritis) before at 2 6 months treatment. Overall a significant change observed 28 with patients. However, MIG/CXCL9, IP-10/CXCL10, CCL23 decreased all patients' groups successful both time points. At months, 29/64...
Abstract Objective: The effect of triclosan (2,4,4′‐trichloro‐2′‐hydroxydiphenyl ether) on the expression cyclooxygenase‐2 (COX‐2) and microsomal prostaglandin E synthase‐1 (mPGES‐1) translocation nuclear factor‐ κ B (NF‐ B) in relation to 2 (PGE ) production was investigated human gingival fibroblasts challenged with tumor necrosis factor α (TNF ). Methods: Fibroblasts were established from biopsies obtained six children. COX‐2 mRNA protein quantified using quantitation enzyme immunometric...
Abstract Background, aims: The effect of triclosan (2,4,4′‐trichloro‐2′‐hydroxyl‐diphenyl ether) on the production interferon‐γ (IFN‐γ) and expression major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals. Methods/Results: AII cell lines demonstrated high IFN‐γ 24‐h cultures stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human showed a MHC when with 500 1000 pg/ml rIFN‐γ 7‐day cultures. Treatment cells (0.5 μg/ml)...
Mechanical stress generated by orthodontic force is recognized as a major factor in the modulation of alveolar bone remodeling. During this process, osteoblasts play crucial role, not only participating formation but also promoting osteoclastogenesis. The aim study was to investigate how continuous compressive ( CF ) affects human primary HOB s) terms cell proliferation, apoptosis, and expression interleukin‐6 IL ‐6) chemokine CXC ligand 8 CXCL 8). Human osteoblasts, isolated from mandibular...
FGFR3 mutations cause wide spectrum of disorders ranging from skeletal dysplasias (hypochondroplasia, achondroplasia, and thanatophoric dysplasia), benign skin tumors (epidermal nevi, seborrhaeic keratosis, acanthosis nigricans), epithelial malignancies (multiple myeloma prostate bladder carcinoma). Hypochondroplasia is the most common type short-limb dwarfism in children resulting fibroblast growth factor receptor 3 (FGFR3) mutation. Acanthosis nigricans might be seen severe dysplasia,...
Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disease affecting lipoprotein metabolism. FCS estimated to occur in 1 1-2 million individuals and can be diagnosed at any age, equally all genders, races, ethnicities. The condition characterized by hypertriglyceridemia, which may predispose patients acute pancreatitis. In this report, we present the case of now 6-year-old girl with on gemfibrozil dietary restrictions. patient initially presented 40 days age vomiting....
There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility inflammatory biomarkers from dry blood spots (DBS) as tool EPTB. In prospective cohort study, 40 were investigated DBS samples 105 EPTB cases using Luminex platform. The taken before, and, at end 2nd and 6th months treatment. A total 11 host changed significantly with all patients. CXCL9/MIG, CCL20, CCL23, CXCL10/IP-10, CXCL1, CXCL2, CXCL8...
The effect of the dentifrice ingredient triclosan (2,4,4'-trichloro-2'-hydroxyldiphenyl ether) on production interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) vitro. When were treated simultaneously (0.25, 0.5 microg/ml) TNFalpha (10 ng/ml), stimulatory IL-1beta reduced by agent. In situ hybridisation showed that TNFalpha-induced expression mRNA significantly triclosan. Furthermore, when cells a known protein...
Many people with dementia (PwD) live and die undiagnosed untreated pain are no longer able to report their suffering. Several assessment tools have been developed, tested, implemented in clinical practice, but nursing home patients reported be still pain. Clinicians research groups worldwide seeking novel approaches encode the prediction, prevalence, associations PwD.The data this analysis acquired from COSMOS study, a cluster-randomized controlled trial (2014 2015), aimed improve quality of...
Abstract Background The mouth is a central organ for communication and fluid intake, also dying nursing home patients. This study describes the prevalence severity of oral symptoms from admission until day perceived death. Methods A prospective, longitudinal cohort including 696 patients who were admitted to 47 Norwegian homes in 35 municipalities. During first year their stay, 189 died (27%), whom 82 participants assessed on they as 134 Mouth care, nutrition, bedsores with Residents’...
Background: Hysterectomy is the removal of uterus and it commonest major surgical procedure after caesarean section performed in gynecology.Aim: This study aimed to examine women's knowledge self-care practices post hysterectomy surgery.Methodology; Design: Descriptive study.Participants: 60 women undergoing at a hospital Egypt.Data Collection: Three tools: (I) Structured interview questionnaire, (II) Self-reported (III) practice questionnaire.Key findings: Knowledge:
Abstract Melanoma patients initially respond well to first line immunotherapy. However, cross resistance immunotherapy and BRAF/MEK inhibitor is a clinical challenge for melanoma care. To investigate drug tolerant resistant mechanisms promoting resistance, we analyzed RNA-sequencing gene set enrichment targeted therapy cells revealing an enriched arachidonic acid signature. Intracellular levels were increased in models. Arachidonic enzymatically converted by COX1 COX2 prostaglandins, which...
In the present study we investigated capacity of human first trimester forebrain cells at different gestational ages to produce IFN-gamma and IL-4. We also studied effects on their proliferation, survival expression MHC antigens. but not IL-4 was spontaneously produced after 24 h cultures. Furthermore, exhibited anti-proliferative induced these cells. However, exposed cultures showed significantly higher cell compared un-exposed Co-culture with blocked production reversed its effects. These...
This study aimed to assess the appropriateness of direct oral anticoagulants (DOACs) utilization in a Saudi tertiary hospital.Adult inpatients and outpatients diagnosed with atrial fibrillation, deep vein thrombosis, or pulmonary embolism were included retrospective cohort study. Patients received at least one month apixaban, rivaroxaban, dabigatran. The duration Armed Forces Hospital Southern Region Khamis Mushait, Arabia, was from January 1, 2019, December 31, 2021. assessed DOACs dosing,...
Transient neonatal diabetes mellitus (TNDM) is the most common cause of in first week life, with an overall incidence 1 90,000 to 160,000 live births. TNDM occurs soon after birth and undergoes spontaneous remission during infancy; however, it may relapse a permanent form childhood or adolescence. We report case due hypomethylation on chromosome 6q24, associated rare clinical finding nonsuppurative submandibular sialadenitis managed by subcutaneous insulin, who underwent three months age....
Permanent neonatal diabetes mellitus (PNDM) appears within the first six months of life.It represents 50% cases diabetes.Affected neonates present with hyperglycemia, intrauterine growth retardation, polyuria, dehydration, and failure to thrive.
Diabetic neuropathy is a major cause of morbidity among diabetics, usually affecting patients with long-standing diabetes and advancing age. We present case atypical first clinical presentation type 1 mellitus (T1DM) in pediatric patient. A 15-year-old male patient presented to the emergency department complaints right foot weakness associated mild paresthesia 1-week duration. There were polyuria, polydipsia weight loss same timeframe. On subsequent examination, exhibited signs right-sided...
Background: Enhanced recovery after surgery (ERAS) has been tested in a wide variety of surgeries with promising outcomes. However, there is need for standardized, evidence-informed approach to both the development new ERAS Society guidelines, and adaptation revision existing guidelines. Developing countries have limited resources deserve every effort improve economic status. Aim Study: evaluate perinatal maternal outcomes ERAS® versus routine care protocols women undergoing elective...