A5007706822- Breast Lesions and Carcinomas
- Dialysis and Renal Disease Management
- Breast Cancer Treatment Studies
- Literary Theory and Cultural Hermeneutics
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Short Stories in Global Literature
- Pain Mechanisms and Treatments
- Postcolonial and Cultural Literary Studies
- American and British Literature Analysis
- Frailty in Older Adults
- Hip and Femur Fractures
- 3D Printing in Biomedical Research
- Advanced Proteomics Techniques and Applications
- AI in cancer detection
- Biosensors and Analytical Detection
- Cancer Risks and Factors
- Menstrual Health and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vascular anomalies and interventions
- Pulmonary Hypertension Research and Treatments
- Bone health and osteoporosis research
- Insect Pest Control Strategies
- Cancer and Skin Lesions
Shiraz University of Medical Sciences
2022-2025
Iranshahr University
2022-2025
Karolinska Institutet
2023-2024
Shahid Beheshti University of Medical Sciences
2024
Islamic Azad University of Shahrekord
2023
Islamic Azad University Mahshahr
2023
Iran University of Medical Sciences
2021-2022
Motamed Cancer Institute
2017-2022
Academic Center for Education, Culture and Research
2017-2022
Islamic Azad University, Babol
2020-2022
Abstract Protein corona, a layer of biomolecules primarily comprising proteins, forms dynamically on nanoparticles in biological fluids and is crucial for predicting nanomedicine safety efficacy. The protein composition the corona typically analyzed using liquid chromatography-mass spectrometry (LC-MS/MS). Our recent study, involving identical samples by 17 proteomics facilities, highlighted significant data variability, with only 1.8% proteins consistently identified across these centers....
The protein corona, a dynamic biomolecular layer that forms on nanoparticle (NP) surfaces upon exposure to biological fluids is emerging as valuable diagnostic tool for improving plasma proteome coverage analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Here, we show spiking small molecules, including metabolites, lipids, vitamins, and nutrients (namely, glucose, triglyceride, diglycerol, phosphatidylcholine, phosphatidylethanolamine, L-α-phosphatidylinositol, inosine...
The protein corona formed on nanoparticles (NPs) has potential as a valuable diagnostic tool for improving plasma proteome coverage. Here, we show that spiking small molecules, including metabolites, lipids, vitamins, and nutrients into can induce diverse patterns otherwise identical NPs, significantly enhancing the depth of profiling. coronas polystyrene NPs when exposed to treated with an array molecules allows detection 1793 proteins marking 8.25-fold increase in number quantified...
While a number of efficient chemical proteomics methods are available for determining protein targets pharmaceutical drugs, each approach exhibits its own 'blind spot' and development complementary techniques is needed. Here, we introduce the Above-Filter Digestion Proteomics (AFDIP) based on monitoring rate trypsin digestion. decreased at site ligand binding to target protein, while other sites may simultaneously experience an increase digestion rate. Molecular dynamics (MD) simulations...
The building and construction sector are a significant contributor to greenhouse gas (GHG) emissions, accounting for approximately 40% of global energy-related CO2 emissions. High-rise buildings, in particular, have substantial environmental impacts due the extensive materials energy required their operation. This study analyses impact three different slab designs on Life Cycle Assessment (LCA) high-rise design. As example building, Pontina Tower, 128-meter concrete Italy, will be...
The prevalence of frailty is disproportionately increased in patients with chronic kidney disease (CKD) comparison non-CKD counterparts and the highest on hemodialysis (HD). While cross-sectional measurement HD has been associated adverse clinical events, there a paucity data longitudinal assessment its relationship to outcomes.The objectives were (1) evaluate changes status, level independence, mood, cognition, quality life (QoL) over 12-month period (2) explore between status QoL at 2...
Abstract Background In order to combat rising rates of antimicrobial resistant infections, it is vital that stewardship become embedded in primary health care (PHC). Despite the high use antimicrobials PHC settings, there a lack data regarding integration programs (ASP) non-hospital settings. Our research aimed determine which interventions are optimal introduce into clinics beginning engage with an ASP, as well how optimize those interventions. This work became focused specifically around...
Background and objectives Patients with CKD exhibit heterogeneity in their rates of progression to kidney failure. The failure risk equation (KFRE) has been shown accurately estimate adults CKD. Our objective was determine health care utilization patterns patients on the basis progression. Design, setting, participants, & measurements We conducted a retrospective cohort study eGFR 15–59 ml/min per 1.73 m 2 enrolled multidisciplinary clinics province Saskatchewan, Canada. Data were...
Peritoneal dialysis (PD) is an underutilized, therapeutic option to in-center hemodialysis (HD), given its similar survival and clinical efficacy but provides lifestyle benefits cost savings. Despite these advantages, PD prevalence rates remains below 20% in many Canadian jurisdictions.The primary objective of this study was identify assess patient-perceived barriers implementation Saskatchewan. The secondary objectives were examine variations by units (main vs satellite units) specific...
Despite clinical and lifestyle advantages of home hemodialysis (HHD) compared with in-center (ICHD), it remains underutilized in our province. The aim the study was to explore patients' perception identify barriers use HHD Saskatchewan, Canada.The primary objective evaluate patient perceptions obstacles for adoption Saskatchewan. secondary examine variations by center (main dialysis units vs satellite units).This is a cross-sectional observational survey study.Two major centers (Regina...
Background: Despite the magnitude of fracture and consequences in patients receiving hemodialysis, optimal risk assessment tools this population are not well explored. Frailty falls—known factors for chronic kidney disease (CKD) non-CKD populations—are common hemodialysis (HD) therapy. While relationship between T scores relation to fractures HD is recognized, there a paucity data additional contributions tool (FRAX), frailty status, falls its with fracture. Objectives: To evaluate clinical...
Background: In the recent decades controlling postoperative pain has become a popular topic as it leads to patients' wellbeing and improved life quality, while reduces costs for both patients medical facilities. Objectives: This study aimed at comparing intravenous magnesium sulfate versus sufentanil on duration of analgesia in undergoing tibia fracture surgery. Methods: double blind clinical trial was performed 70 candidates fractures between ages 18 55 years with American society...
Opening the blood brain barrier (BBB) under imaging guidance may be useful for treatment of many disorders. Rapidly applied magnetic fields have potential to generate electric in tissue that, if properly timed, enable safe and effective BBB opening. By tuning pulses generated by a novel electropermanent magnet (EPM) array, we demonstrate opening tight junctions model culture vitro, show that induced monophasic electrical are more than biphasic ones. We confirmed, with vivo contrast-enhanced...
We investigated the immediate molecular consequences of traumatic brain injuries (TBIs) using a novel proteomics approach. simulated TBIs an innovative laboratory apparatus that employed 5.1 kg dummy head held neuronal cells and generated ≤4000 g-force acceleration upon impact. A Proteome Integral Solubility Alteration (PISA) assay was then to monitor protein solubility changes in system-wide manner. Dynamic impacts led both reduction neuron viability massive proteome. The affected proteins...