A5013758147- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Developmental Biology and Gene Regulation
- Aldose Reductase and Taurine
- Peroxisome Proliferator-Activated Receptors
- Photosynthetic Processes and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Retinal Development and Disorders
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Algal biology and biofuel production
- Congenital heart defects research
- Synthetic Organic Chemistry Methods
- Photochromic and Fluorescence Chemistry
- Prenatal Substance Exposure Effects
- Silicon Nanostructures and Photoluminescence
- Neuroscience and Neuropharmacology Research
- Microbial Natural Products and Biosynthesis
- Neuroblastoma Research and Treatments
- Carbohydrate Chemistry and Synthesis
- Neurogenesis and neuroplasticity mechanisms
- Proteoglycans and glycosaminoglycans research
- Viral-associated cancers and disorders
- Asymmetric Synthesis and Catalysis
Universidade de Vigo
2012-2025
Hospital Universitario Fundación Jiménez Díaz
2020
Google (United States)
2016
Instituto Español de Oceanografía
2013
Université de Strasbourg
2010-2011
Centre National de la Recherche Scientifique
2010-2011
Institut de Science et d'Ingénierie Supramoléculaires
2010
University of Kansas
2009
Case Western Reserve University
2008-2009
Sidney Kimmel Cancer Center
2008
Retinoic acid (RA) treatment of SH-SY5Y neuroblastoma cells results in activation phosphatidylinositol-3-kinase (PI3K) signaling pathway, and this is required for RA-induced differentiation. Here we show that RA activates PI3K ERK1/2 MAPK pathways through a rapid, nongenomic mechanism does not require new gene transcription or newly synthesized proteins. Activation by appears to involve the classical nuclear receptor, retinoic receptor (RAR), on basis pharmacological profile activation,...
The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling variety (patho)-physiological processes. Although synthetic RXR ligands developed for the treatment various diseases, endogenous ligand(s) these have not been conclusively identified. We show here that mice lacking cellular retinol binding protein (Rbp1-/-) display memory deficits reflecting compromised signaling. Using HPLC-MS and...
A major challenge in neurobiology is to understand mechanisms underlying human neuronal diversification. Motor neurons (MNs) represent a diverse collection of subtypes, displaying differential vulnerability different neurodegenerative diseases. The ability manipulate cell subtype diversification critical establish accurate, clinically relevant vitro disease models. Retinoid signalling contributes caudal precursor specification and subsequent MN Here we investigate the necessity for retinoic...
The discovery of small molecule probes which selectively modulate biological pathways is a cornerstone in the development new therapeutics. Progress our ability to access libraries biologically relevant molecules conjunction with streamlined screening technologies have also enabled more systematic approach chemical biology. Nevertheless, current state art still requires large infrastructure and only fraction proteome has been addressed thus far. emergence based on nucleic acid encoding...
On the basis of observations that chalcone 7 (MX781) and some related adamantyl arotinoids (AdArs) inhibit IkappaB alpha kinase beta (IKKbeta) activity, cell growth, induce apoptosis in cancer cells, a new series AdArs structurally to have been designed synthesized. Modifications were intended reduce or eliminate RAR we evaluated effect novel analogues on IKKbeta activity proliferation variety lines (leukemia, Jurkat; prostate, PC-3; breast carcinomas, T47D, MDA-MB-468). Consistent with...
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Lewis acid catalyzed Friedel–Crafts alkylation of indoles has been achieved in high yields and selectivities using p-quinols as electrophiles. (S)-Binol-3,3′-(9-anthracenyl)-phosphoric was able to catalyze the enantioselective formation 5-(3-indole)-2-cyclohexenone derivatives. Experimental results theoretical calculations explained enantioselectivity based on a transition state where two water molecules act tether joining p-quinol with phosphoric NH indole, thus facilitating...
The total synthesis of the stereoisomer muanlactam predicted by DP4+ calculations, which differed from that reported for natural product on relative configuration at C19, was completed, and structure polyenic macrolactam fully confirmed. Construction stereocenters involved iterative enantio- diastereoselective Krische's allylation reaction formal syn-1,3-diol addition a propargylic Grignard reagent to Ellman's chiral nonracemic tert-butylsulfinamide enantiopure amine fragment. conjugated...
Abstract Background In most eumetazoans studied so far, Hox genes determine the identity of structures along main body axis. They are usually linked in genomic clusters and, case vertebrate embryo, expressed with spatial and temporal colinearity. Outside vertebrates, colinearity has been reported cephalochordate amphioxus (the least derived living relative chordate ancestor) but only for anterior central genes, namely Hox1 to Hox4 Hox6 . However, gene expression patterns have not reported....
Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated various diseases. The present study used topical application of selective agonists antagonists for receptors (RARs) α γ retinoid-X (RXRs) two weeks on mouse order determine the role receptor subtypes gene regulation skin. We observed pronounced epidermal hyperproliferation upon ATRA synthetic RARγ RXR....
The enzyme retinol saturase (RetSat) catalyzes the saturation of all-irans-retinol to produce (R)-all-trans-13,14-dihydroretinol. As a peroxisome pro-liferator-activated receptor (PPAR) γ target, RetSat was shown be required for adipocyte differentiation in 3T3-L1 cell culture model. To understand mechanism involved this putative proadipogenic effect RetSat, we studied consequences ablating expression on retinoid metabolism and adipose tissue RetSat-null mice. Here, report that mice have...
Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number genes. Stereospecific saturation C<sub>13</sub>-C<sub>14</sub> double bond all-<i>trans</i>-retinol by enzyme, retinol saturase (RetSat), leads to production (<i>R</i>)-all-<i>trans</i>-13,14-dihydroretinol. In liver and adipose tissue, RetSat is controlled peroxisome proliferator-activated (PPAR) α γ, respectively. Expression in tissue also required PPARγ activation adipocyte...
Although chordates descend from a segmented ancestor, the evolution of head segmentation has been very controversial for over 150 years. Chordates generally possess pharynx, but even though anatomical evidence and gene expression analyses suggest homologies between pharyngeal apparatus invertebrate chordates, such as cephalochordate amphioxus, vertebrates, these remain contested. We, therefore, decided to study chordate by examining molecular mechanisms underlying morphogenesis in an animal...
Retinol saturase carries out a stereospecific saturation of the C13−C14 double bond all-trans-retinol to generate (13R)-all-trans-13,14-dihydroretinol. This compound is found in cells expressing mouse or zebrafish retinol and livers mice fed retinyl palmitate. All-trans-13,14-dihydroretinol oxidized vivo all-trans-13,14-dihydroretinoic acid, highly selective agonist retinoic acid receptor. The naturally occurring (13R)-all-trans-13,14-dihydroretinoic weaker than (13S) enantiomer, indicating...