A5049886574- Retinoids in leukemia and cellular processes
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Aldose Reductase and Taurine
- Marine Biology and Ecology Research
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- Photochromic and Fluorescence Chemistry
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Prenatal Substance Exposure Effects
- Marine Ecology and Invasive Species
- Heme Oxygenase-1 and Carbon Monoxide
- Peroxisome Proliferator-Activated Receptors
- Marine Bivalve and Aquaculture Studies
- Marine and coastal plant biology
- Retinal Diseases and Treatments
- Hormonal and reproductive studies
- Computational Drug Discovery Methods
- Digital Mental Health Interventions
- Asymmetric Synthesis and Catalysis
- Ichthyology and Marine Biology
Parc Sanitari Sant Joan de Déu
2023
Institut de Recerca Sant Joan de Déu
2023
Universidade de Vigo
2007-2021
Rede de Química e Tecnologia
2020
Galicia Sur Biomedical Foundation
2020
Universidad Politécnica de Madrid
2017
Chemical Genomics Centre
2009-2012
Max Planck Society
2009-2012
Universidad de Salamanca
2011
Case Western Reserve University
2007-2009
AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer types and precancerous lesions. In vitro, exhibits much higher retinaldehyde activity than any other AKR, including AKR1B1 (aldose reductase). We here demonstrate that also acts as vivo. This may relevant controlling the first step of retinoic acid synthesis. Up-regulation AKR1B10, resulting depletion, lead cellular proliferation. Both vitro vivo activities were inhibited by tolrestat, an inhibitor developed...
The enzyme retinol saturase (RetSat) catalyzes the saturation of all-irans-retinol to produce (R)-all-trans-13,14-dihydroretinol. As a peroxisome pro-liferator-activated receptor (PPAR) γ target, RetSat was shown be required for adipocyte differentiation in 3T3-L1 cell culture model. To understand mechanism involved this putative proadipogenic effect RetSat, we studied consequences ablating expression on retinoid metabolism and adipose tissue RetSat-null mice. Here, report that mice have...
Lanthanide (Eu and Nd)-doped hydrocalumite has been prepared by a coprecipitation method. All samples, with Eu3+ Nd3+ contents up to 4% (molar ratio), show single crystallographic phase, without segregation of secondary lanthanide-containing phases. Calcination affords lime mayenite, lanthanide cations embedded in the structure. The photoluminescence spectra noncalcined samples consist (in visible region) NIR) intra-4f transitions broad band ascribed Al-related defects. Eu3+5D0 lifetime...
Metabolism of vitamin A, all-trans-retinol, leads to the formation 11-cis-retinaldehyde, visual chromophore, and all-trans-retinoic acid, which is involved in regulation gene expression through retinoic acid receptor. Enzymes binding proteins retinoid metabolism are highly conserved across species. We previously described a novel mammalian enzyme that saturates 13-14 double bond all-trans-retinol produce all-trans-13,14-dihydroretinol, then follows same metabolic fate as all-trans-retinol....
Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number genes. Stereospecific saturation C<sub>13</sub>-C<sub>14</sub> double bond all-<i>trans</i>-retinol by enzyme, retinol saturase (RetSat), leads to production (<i>R</i>)-all-<i>trans</i>-13,14-dihydroretinol. In liver and adipose tissue, RetSat is controlled peroxisome proliferator-activated (PPAR) α γ, respectively. Expression in tissue also required PPARγ activation adipocyte...
As an extension of our synthesis symmetrical carotenoids, the preparation highly functionalized C37-norcarotenoid butenolide peridinin (1), its 6'-epi- and 11'Z stereoisomers has been completed. Featuring a central dihalogenated C8 linchpin unit 6, two synthetic routes, differing in ordering last three steps were explored by using C3,C3'-bisdehydroxylated target as model system. The first route uses combination modified Z-selective Julia reaction sequential Stille couplings, one producing...
Retinol saturase carries out a stereospecific saturation of the C13−C14 double bond all-trans-retinol to generate (13R)-all-trans-13,14-dihydroretinol. This compound is found in cells expressing mouse or zebrafish retinol and livers mice fed retinyl palmitate. All-trans-13,14-dihydroretinol oxidized vivo all-trans-13,14-dihydroretinoic acid, highly selective agonist retinoic acid receptor. The naturally occurring (13R)-all-trans-13,14-dihydroretinoic weaker than (13S) enantiomer, indicating...
Species belonging to the family Aeolidiidae (Opisthobranchia: Nudibranchia) were studied. The specimens collected from localities in two states of Brazil (Rio de Janeiro and Bahia). Some Western Atlantic Berghia Trinchese, 1877 previously assigned verrucicornis (A. Costa, 1864). study Brazilian coast allowed us observe diverse characters, such as presence orange markings at bases cerata, which differ Mediterranean Eastern Atlantic. species B. is different Berghia. Our belong a new species,...
Abstract In an effort to push olefin metathesis the limits of conjugation in reactants and products, C 40 ‐symmetrical carotenoids β,β‐carotene ( 1 ), lycopene 2 (3 R ,3′ )‐zeaxanthin 3 rac ‐isozeaxanthin 4 which are conjugated undecaenes, have been synthesized from 21 ‐terminal hexaenes by treatment with Grubbs' second‐generation Ru catalyst dichloromethane at 50 °C.
Abstract The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles diabetes, inflammatory disorders, cancer. In this study we identified two new lead compounds, 2‐(3‐(4‐chloro‐3‐nitrobenzyl)‐2,4‐dioxo‐3,4‐dihydropyrimidin‐1(2 H )‐yl)acetic acid (JF0048, 3 ) 2‐(2,4‐dioxo‐3‐(2,3,4,5‐tetrabromo‐6‐methoxybenzyl)‐3,4‐dihydropyrimidin‐1(2 (JF0049, 4 ), which selectively target these enzymes. Although share the 3‐benzyluracil‐1‐acetic scaffold, they...
Total synthesis and structural confirmation of homo- heterodimeric bispyrrolidinoindoline dioxopiperazine alkaloids isolated from fungi bacteria, namely, ditryptoleucine A, B (11), the N,N′-bis-demethylated analogue (+)-12, (−)-dibrevianamide F (13), (−)-SF-5280-451 (14), tetratryptomycin A (15), (−)-tryprophenaline (17), (−)-SF-5280-415 (18), has been carried out starting corresponding bispyrrolidinoindolines derived tryptophan. Our efforts to synthesize all possible diastereomers natural...
The sequential Stille cross-coupling reactions of the dihalogenated γ-alkylidenebutenolide 7 with stannanes 9 and 6 afforded carbon skeleton pyrrhoxanthin, a highly functionalized C7'−C8' acetylenic C37-norcarotenoid butenolide. Although first halogen-selective coupling takes place in 90% yield at ambient temperature, double isomerization Z,E- to E,Z-C7'−C10' enyne, likely induced by catalyst, accompanyied bond formation, leading 9'Z-20 and, ultimately, 9'Z-pyrrhoxanthin 9'Z-1.
A library of small tetrahydroisoquinoline ligands, previously identified via structure- and chemistry-based hierarchical organization scaffolds in tree-like arrangements, has been generated as novel estrogen receptor agonistic fragments traditional medicinal chemistry exploration. The approach described allowed for the rapid evaluation a structure−activity relationship ligands concerning affinity β subtype selectivity. structural biological insights obtained from aid understanding larger...
Background: Although many studies analyse gender differences in the clinical expression of Attention Deficit Hyperactivity Disorder (ADHD) and prevalence show that girls with ADHD are underdiagnosed, there no instruments sensitive to detection ADHD. Objective: The objective this study is develop a self-report early instrument for boys aged 7 16, which includes perspective Methods: development scale items comprise it were created from thematic analysis its evaluation children, based on...
This paper describes a study of the nudibranchs from family Chromodorididae Bergh, 1891 that were sampled in several expeditions along coast Rio de Janeiro, São Paulo and Fernando Noronha (Brazil).A total eight species this studied new species, Chromodoris paulomarcioi n. sp., is described.The taxon Hypselodoris picta lajensis Troncoso, García Urgorri, 1998, proposed for consideration within taxonomic category records some are provided.
Miniproteins featuring a stable α-helical motif allow exploring point mutations in and around FXXLF motifs to improve androgen receptor affinity.
Ring-oxidized retinoids have been synthesized stereoselectively using the Stille cross-coupling reaction. Kinetic constants of mouse class I alcohol dehydrogenase (ADH1) with these were determined.
Upon heating to 80 °C, 11-cis-retinal yields a mixture of all-trans-retinal and 13-cis-retinal. This isomerization has been studied by means density functional theory methods, the computational results suggest close competition between two mechanisms very different nature. A classical internal rotation around C11−C12 cis double bond, via diradical transition state, accounts for formation all-trans isomer. An intricate sequence pericyclic reactions, namely reversible [1,7]-H sigmatropic shift...