A5089535333- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Aldose Reductase and Taurine
- Retinoids in leukemia and cellular processes
- Chemical Synthesis and Analysis
- Protein Structure and Dynamics
- Peroxisome Proliferator-Activated Receptors
Imperial College London
2017-2018
Transnational Press London
2017-2018
Universitat Autònoma de Barcelona
2012
A novel amphiphile with a dendronic hydrophobic group (DTM-A6) was markedly effective at stabilizing and visualizing GPCR-G<sub>s</sub> complex.
Membrane proteins play critical roles in a variety of cellular processes. For detailed molecular level understanding their biological functions and disease, it is necessary to extract them from the native membranes. While amphipathic nature these bio-macromolecules presents technical challenges, amphiphilic assistants such as detergents serve useful tools for membrane protein structural functional studies. Conventional are limited ability maintain integrity thus essential develop novel...