A5065520604- Effects and risks of endocrine disrupting chemicals
- Environmental Justice and Health Disparities
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Gestational Diabetes Research and Management
- Telomeres, Telomerase, and Senescence
- Endometriosis Research and Treatment
- Noise Effects and Management
- Gynecological conditions and treatments
- Pregnancy and Medication Impact
- Indoor Air Quality and Microbial Exposure
- Urban Green Space and Health
- Environmental Education and Sustainability
- Heavy metals in environment
- Carcinogens and Genotoxicity Assessment
- Environmental and Social Impact Assessments
- Menstrual Health and Disorders
- Chemical Analysis and Environmental Impact
- Risk Perception and Management
Columbia University
2021-2025
Milken Institute
2015-2024
George Washington University
2015-2024
Harvard University
2005-2023
University of North Carolina at Chapel Hill
2021-2023
Harlem United
2023
National Institute of Environmental Health Sciences
2023
Johns Hopkins University
2023
Centers for Disease Control and Prevention
2023
Scientific Systems (United States)
2023
Exposure to chemicals during fetal development can increase the risk of adverse health effects, and while biomonitoring studies suggest pregnant women are exposed chemicals, little is known about extent multiple exposures among in United States.We analyzed data from National Health Nutritional Examination Survey (NHANES) characterize both individual chemical U.S. women.We for 163 analytes 12 classes subsamples 268 NHANES 2003-2004, a nationally representative sample population. For each...
Background: Phthalates are ubiquitous environmental contaminants. Because of potential adverse effects on human health, butylbenzyl phthalate [BBzP; metabolite, monobenzyl (MBzP)], di-n-butyl [DnBP; mono-n-butyl (MnBP)], and di(2-ethylhexyl) (DEHP) being replaced by substitutes including other phthalates; however, little is known about consequent trends in population-level exposures.Objective: We examined temporal urinary concentrations metabolites the general U.S. population whether vary...
The obstetrics-gynecology community has issued a call to action prevent toxic environmental chemical exposures and their threats healthy human reproduction. Recent committee opinions recognize that vulnerable underserved women may be impacted disproportionately by recommend reproductive health professionals champion policies secure justice. Beauty product use is an understudied source of exposures. products can include developmental toxicants such as phthalates heavy metals; however,...
Phthalates and bisphenol A (BPA) are widely used industrial chemicals that may adversely impact human health. Human exposure is ubiquitous can occur through diet, including consumption of processed or packaged food.To examine associations between recent fast food intake BPA urinary metabolites di(2-ethylhexyl) phthalate (ΣDEHPm) diisononyl (DiNPm) among the U.S.We combined data on 8,877 participants from National Health Nutrition Examination Survey (NHANES 2003-2010). Using 24-hr dietary...
Abstract Background Fast food consumption is associated with biomarkers of ortho-phthalates exposures. However, the chemical content fast unknown; certain (i.e., di- n -butyl phthalate (DnBP) and di(2-ethylhexyl) (DEHP)) have been phased out replaced other plasticizers (e.g., dioctyl terephthalate (DEHT)). Objective We conducted a preliminary study to examine ortho-phthalate replacement plasticizer concentrations in foods handling gloves from U.S. restaurants. Methods obtained hamburgers,...
Studies show higher house dust and body burden levels of PBDE flame retardants in North America than Europe; but little is known about exposure variation within America, where California's furniture flammability standard affects use. We compared samples from 49 homes two California communities with 120 Massachusetts other published studies. Dust concentrations [median (range) ng/g] BDE-47, -99, -100 were 2700 (112-107 000), 3800 (102-170 684 (<MRL-30 900), respectively, 4−10 times previously...
Objectives. The indoor environment has not been fully incorporated into the environmental justice dialogue. To inform strategies to reduce disparities, we developed a framework identify individual and place-based drivers of quality. Methods. We reviewed empirical evidence socioeconomic disparities in exposures key determinants these for air pollutants, lead, allergens, semivolatile organic compounds. also used an quality model applied multifamily housing illustrate how nitrogen dioxide (NO 2...
Background: Manganese is both an essential element and a known neurotoxicant to children. High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies examined the effects of human fetal exposure. Methods: We studied association between maternal umbilical cord blood levels birth weight cohort 470 mother-infant pairs born at term (≥37 weeks gestation) Ottawa County, Oklahoma. Nonlinear spline quadratic regression models were used...
Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute adverse neurodevelopmental outcomes. We conducted a pilot study explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 -154), higher-brominated (BDE-183 -209), hydroxylated PBDE metabolites (OH-PBDEs) with measures in pregnant women. Concentrations PBDEs, OH-PBDEs, thyroid-stimulating hormone (TSH), total thyroxine (T4), free T4 were measured samples...
Background Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL cardiovascular disease. This may be due in part to the relationship with other biomarkers associated disease risk. However, strength adiposity, metabolic, proinflammatory, has not been systematically evaluated United States nationally representative population. Methods Findings We examined 17 biomarkers, including lipoproteins, blood sugar,...
Prenatal exposures to polybrominated diphenyl ethers (PBDEs) can harm neurodevelopment in humans and animals. In 2003-2004, PentaBDE OctaBDE were banned California phased-out of US production; resulting impacts on human are unknown. We previously reported that median serum concentrations PBDEs their metabolites (OH-PBDEs) among second trimester pregnant women recruited from San Francisco General Hospital (2008-2009; n = 25) the highest worldwide. another cohort same clinic 2011-2012 (n 36)...
Numerous methods exist to analyze complex environmental mixtures in health studies. As an illustration of the different uses mixture methods, we employed geared toward distinct research questions concerning persistent organic chemicals (POPs) as a and leukocyte telomere length (LTL) outcome. With information on 18 POPs LTL among 1,003 U.S. adults (NHANES, 2001–2002), used unsupervised including clustering identify profiles similarly exposed participants, Principal Component Analysis (PCA)...
Diethyl phthalate (DEP) and di-n-butyl (DnBP) are industrial chemicals found in consumer products that may increase risk of adverse health effects. Although use personal care/beauty is known to contribute exposure, no prior study has examined feminine hygiene as a potential source. In this study, we evaluate whether vaginal douching other exposure phthalates among US reproductive-aged women.We conducted cross-sectional on 739 women (aged 20-49) from the National Health Nutrition Examination...
Bisphenol A (BPA) is a ubiquitous, endocrine-disrupting environmental contaminant that increases risk of some adverse developmental effects. Thus, it important to characterize BPA levels, metabolic fate and sources exposure in pregnant women. We used an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytic method directly simultaneously measure unconjugated (uBPA), glucuronide sulfate the urine population ethnically racially diverse, predominately low-income women (n =...
Robust data from longitudinal birth cohort studies and experimental of perinatally exposed animals indicate that exposure to ortho-phthalates can impair brain development increase risks for learning, attention, behavioral disorders in childhood. This growing body evidence, along with known adverse effects on male reproductive tract development, calls immediate action.Exposures are ubiquitous; the majority people multiple simultaneously. We thus recommend a class approach be used assessing...
Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth. To investigate the prospective association between urinary biomarkers of phthalates in pregnancy birth individuals living US. Individual-level data were pooled from 16 preconception studies conducted Pregnant who delivered 1983 2018 provided 1 or more urine samples during included. Urinary phthalate metabolites quantified as exposure. Concentrations 11 standardized dilution mean repeated...
Hypertensive disorders of pregnancy (HDP), defined here as hypertensive with onset in (i.e., gestational hypertension, preeclampsia, and preeclampsia superimposed on chronic hypertension), affect up to 10% pregnancies the United States are associated substantial maternal neonatal morbidity mortality. Per- polyfluoroalkyl substances (PFAS) adverse cardiometabolic outcomes during pregnancy, but associations between PFAS HDP inconsistent joint effects mixtures have not been evaluated. We...
This article examines participants’ responses to receiving their results in a study of household exposure endocrine disrupting compounds and other pollutants. The authors how the “exposure experience”—the embodied, personal experience understanding chronic environmental pollutants—is shaped by community context report-back process itself. In addition, investigate an activist, collective form experience. analyze themes expectations learning, trust, action. findings reveal that while...