A5109327526- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- FOXO transcription factor regulation
- Genetics, Aging, and Longevity in Model Organisms
- Biomarkers in Disease Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Cerebral Venous Sinus Thrombosis
- GDF15 and Related Biomarkers
- Parkinson's Disease Mechanisms and Treatments
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Ferroptosis and cancer prognosis
- Acute Myocardial Infarction Research
Queen's Medical Center
2016-2025
Neuroscience Institute
2015-2025
University of Hawaiʻi at Mānoa
2014-2024
Kuakini Medical Center
2020-2024
GTx (United States)
2022-2023
University of Hawaii System
2012-2021
Tokyo University of Technology
2021
Harvard University Press
2019
University of Hawaii at Hilo
2016-2017
Massachusetts General Hospital
2017
Dynamic cerebral autoregulation after intracerebral hemorrhage (ICH) remains poorly understood. We performed a case-control study to compare dynamic between ICH patients and healthy controls.Twenty-one (66 ± 15 years) with early (< 72 hours) lobar or basal ganglia were prospectively studied compared twenty-three age-matched controls (65 9 years). Continuous measures of mean flow velocity (MFV) in the middle artery arterial blood pressure (MAP) obtained over 5 min. Cerebrovascular resistance...
Studies show that women are more likely to receive do-not-resuscitate (DNR) orders after acute medical illnesses than men. However, the sex differences in use of DNR intracerebral hemorrhage (ICH) have not been described.We conducted a retrospective study consecutive patients hospitalized for ICH at tertiary stroke center between 2006 and 2010. Unadjusted multivariable logistic regression analyses were performed test associations female early (<24 hours presentation) orders.A total 372...
Background and Purpose— Previous studies suggest that dynamic autoregulation in the posterior cerebral artery (PCA) is less efficient compared to middle (MCA). We examined role of vasodilation caused by metabolic activation (ie, visual stimulus) on autoregulatory characteristics 2 vascular territories. Methods— Blood flow velocity PCA MCA mean arterial pressure were measured continuously 45 healthy volunteers (62±3 years) while seated with eyes open. Additional 20 subjects (60±5 closed...
The purpose of this study was to determine the accuracy and optimal timing physician prognostication in patients with subarachnoid hemorrhage, a prototypical neurological disease characterized by variable outcomes frequent disability.From October 2009 April 2010, treating neurologists at tertiary care academic medical center made daily predictions modified Rankin Scale 6 months for consecutive hemorrhage. Actual functional were determined phone interview dichotomized into good (modified 0-2)...
To evaluate disparities in cardiovascular risk factors among Asians and Native Hawaiians other Pacific Islanders (NHPI) Hawaii who are hospitalized with ischemic stroke.We performed a retrospective study on consecutive patients for stroke at single tertiary center Honolulu between 2004 2010. The prevalence of was compared NHPI, Asians, whites were stroke.A total 1,921 studied. NHPI less likely to be older (odds ratio [OR] 0.95, 95% confidence interval [CI] 0.94-0.96), more female (OR 1.55,...
To evaluate disparities in stroke risk factors and outcome among the Native Hawaiians other Pacific Islanders (NHPI) Hawaii who are hospitalized with intracerebral hemorrhage (ICH).We performed a retrospective study on consecutive patients for acute ICH at single tertiary center Oahu between 2004 2010. Clinical data were obtained from Get With Guidelines-Stroke database. Multivariable logistic regression was used to assess predictors young (age <45).A total of 562 (Asian 63%, NHPI 18%, white...
Background Differences among Native Hawaiians/Pacific Islanders (NHPI) and Asian American (AA) subgroups have not been adequately studied in Parkinson's disease (PD). Objective To determine differences demographics, comorbidities, healthcare utilization NHPI, AA subgroups, White hospitalized PD patients. Methods We conducted a retrospective cross-sectional analysis of Hawaiʻis statewide registry (2016–2020). Patients with were identified using ICD10 code G20 categorized as White, Japanese,...
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<h3>Objective:</h3> To assess racial disparities in the prevalence of methamphetamine-associated intracerebral hemorrhage (Meth-ICH) among Native Hawaiians and other Pacific Islanders (NHOPI). <h3>Methods:</h3> Prospectively collected data from an ongoing, multiethnic, single-center cohort study were analyzed. The inclusion criteria for required that patients be adult (age 18 years or older) residents Hawaii with nontraumatic spontaneous (ICH). Patients race than white, Asian, NHOPI...
Not all patients with warfarin-related acute intracranial hemorrhage (ICH) achieve full reversal of international normalized ratio (INR) after the first dose weight-based prothrombin complex concentrate (PCC). We sought to identify factors associated anticoagulation failure PCC.Consecutive who were hospitalized ICH at a tertiary center between 1 January 2010 and 31 December 2012 studied. Anticoagulation was defined as INR ≥ 1.5 PCC. Logistic regression performed determine predictors...
The Affordable Care Act and budget cuts have changed the role of hospital social workers by placing pressure on them to conduct speedy discharges decrease readmission rates. This qualitative study aimed assess if work is meeting needs clients in postdischarge. Semistructured interviews with 10 intracerebral hemorrhage (ICH) 11 caregivers were conducted. Participants reported that services not their needs. Clients ICH expressed from surpassed roles as discharge planners, including counseling,...