- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- BRCA gene mutations in cancer
- Data Mining Algorithms and Applications
- Gut microbiota and health
- Simulation and Modeling Applications
- Advanced Numerical Analysis Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Tryptophan and brain disorders
- Nanoplatforms for cancer theranostics
- Manufacturing Process and Optimization
- Multiple and Secondary Primary Cancers
- Lymphatic System and Diseases
- Cancer-related molecular mechanisms research
- Data Quality and Management
- Cancer Risks and Factors
- Service-Oriented Architecture and Web Services
- Mycobacterium research and diagnosis
- Diet and metabolism studies
- Luminescence and Fluorescent Materials
- Transplantation: Methods and Outcomes
- Distributed and Parallel Computing Systems
- Quantum Computing Algorithms and Architecture
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Shenzhen University
2021-2022
German Cancer Research Center
2021
Heidelberg University
2021
Changshu Institute of Technology
2010
Karolinska University Hospital
1997
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic worldwide. Long non-coding RNAs (lncRNAs) are subclass of endogenous, non-protein-coding RNA, which lacks an open reading frame and is more than 200 nucleotides in length. However, the functions for lncRNAs COVID-19 have not been unravelled. The present study aimed at identifying related based on RNA sequencing peripheral blood mononuclear cells from...
Abstract Fluorophores lay the material basis for tissue labeling and fluorescence imaging, especially deep‐brain multiphoton microscopy (MPM) in animal models. Among various fluorescent materials, those with aggregation‐induced emission (AIE) characteristics, i.e., AIEgens, have excellent optical properties biocompatibility thus found widespread applications biomedical imaging. However, their application to MPM has so far been limited imaging depth, which undoubtedly poses a hindrance...
Three-photon microscopy (3PM) excited at both the 1300 and 1700 nm window are established deep-brain imaging technologies. Beyond lies last unexplored optical potential for 3PM: 2200 window. However, there has been no experimental demonstration of brain 3PM this window, hence quantitative comparison with other excitation windows. Here we demonstrate in vivo, by developing an energetic femtosecond laser a scanning microscope high transmittance minimum pulse broadening. We also perform direct...
Visualization of lymphatic vessels is key to the understanding their structure, function, and dynamics. Multiphoton microscopy (MPM) a potential technology for imaging vessels, but tissue scattering prevents its deep penetration in skin. Here we demonstrate deep-skin MPM mouse hindlimb vivo, excited at 1700 nm window. Our results show that with contrast provided by indocyanine green (ICG), 2-photon fluorescence (2PF) enables noninvasive 300 μm below skin surface, visualizing both structure...
Traditional data integration approaches cannot effectively cope with the autonomous and dynamic characteristics of sources distributed over Internet. They also neglect users’ individualized requirements. Based on real demands Internet for State Grid China, this paper proposes a Service-Oriented Data Integration (SODI) approach. The main contributions include: propose new service model attach more importance key concerns aspects hidden behind interfaces; flexible to support users integrate...
Numerical control machine tools are widely used in the manufacturing nowadays. The engineers often have difficulties discussing with another engineer about problem CAM work, so a convenient tool for this is needed. In paper, framework of collaborative simulation environment presented goal virtual enterprise. main modular and key technology them illustrated, which include part discussion environment, cutting parameter database management modular, G-code VRML based realistic modular. prototype...
Multiphoton microscopy (MPM) excited at the 1700-nm window has enabled deep-tissue penetration in biological tissue, especially brain. MPM of skin may also benefit from this deep-penetration capability. Skin is a layered structure with varying refractive index (from 1.34 to 1.5). Consequently, proper immersion medium should be selected when imaging high numerical aperture objective lens. To provide guidelines for selection MPM, here we demonstrate comparative experimental investigation...