A5044964742- Microbial Natural Products and Biosynthesis
- Cervical Cancer and HPV Research
- Fungal Biology and Applications
- Colorectal and Anal Carcinomas
- Heat shock proteins research
- Genital Health and Disease
- Phytochemicals and Antioxidant Activities
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Microbial Metabolism and Applications
- Nanoparticles: synthesis and applications
- Cancer Research and Treatments
- Dental Implant Techniques and Outcomes
- Toxin Mechanisms and Immunotoxins
- Women's cancer prevention and management
- Plant tissue culture and regeneration
- Hematological disorders and diagnostics
- Tannin, Tannase and Anticancer Activities
- Head and Neck Cancer Studies
- Essential Oils and Antimicrobial Activity
- Immunotherapy and Immune Responses
- Dental materials and restorations
- Cellular Mechanics and Interactions
- HIV-related health complications and treatments
- Inflammatory Biomarkers in Disease Prognosis
Universidade Federal do Maranhão
2017-2025
Euterpe oleracea Mart. (açai) is a native palm from the Amazon region. There are various chemical constituents of açai with bioactive properties. This study aimed to evaluate composition and cytotoxic effects seed extract on breast cancer cell line (MCF-7). Global Natural Products Social Molecular Networking (GNPS) was applied identify compounds present in extract. LC-MS/MS molecular networking were employed detect phenolic açai. The antioxidant activity measured by DPPH assay. MCF-7...
Penile squamous cell carcinoma (PSCC) is a largely neglected condition, predominantly affecting underdeveloped regions, and associated with risk factors such as low socioeconomic status, phimosis, human papillomavirus (HPV) infection. Unlike other urogenital cancers, its pathophysiology therapeutic targets remain poorly understood, particularly regarding the immune response to tumor microenvironment. This study aims investigate infiltration profiles, dendritic maturation, lymphocyte...
Dendritic cells (DCs) are the most efficient antigen-presenting and link innate immune sensing of environment to initiation adaptive responses, which may be directed either acceptance or elimination recognized antigen. In cancer patients, though DCs would expected present tumor antigens T lymphocytes induce tumor-eliminating this is frequently not case. The complex microenvironment subverts response, blocks some effector mechanisms, drives others support growth. Chronic inflammation in a...
This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil.Ethyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. solid Ehrlich tumor model used for antitumor activity. Female Swiss mice divided into groups (n = 10/group) as follows: negative control (CTL-), treated with phosphate buffered solution; positive (CTL+), cyclophosphamide (25 mg/kg); extract...
Notwithstanding the advances in molecular target-based drugs, chemotherapy remains most common cancer treatment, despite its high toxicity. Consequently, effective anticancer therapies with fewer adverse effects are needed. Therefore, this study aimed to determine activity of dichloromethane fraction (DCMF) isolated from Arrabidae brachypoda roots, whose components three unusual dimeric flavonoids. The toxicity DCMF was investigated breast (MCF-7), prostate (DU145), and cervical (HeLa) tumor...
Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types human papillomavirus (HR-HPV) is responsible for >80% cases. The aim this work was detect and perform (HPV) genotyping squamous cell carcinoma specimens anal canal investigate association between viral infection histopathological clinical aspects. presence genotype-specific HPV DNA formalin-fixed paraffin embedded tissue 27 SCC samples a reference hospital São Luís, State Maranhão,...
This study aims to investigate the possible association between neutrophil/lymphocyte and platelet/lymphocyte ratio in women with HIV, undergoing antiretroviral treatment, HPV coinfection. is a cross-sectional HIV positive women; their biological samples were collected for laboratory tests (complete blood count) oncotic cytology detection of DNA, by PCR-Nested (PGMY GP primers). Viral load CD4 CD8 T-cells counts obtained from medical records. The data analyzed, comparing two groups: those...
The present study aimed to evaluate the lipid profile and atherogenic indexes in HIV-positive women with without coinfection human papillomavirus.Preliminary was conducted women. Laboratory tests (lipid profile, glycid indexes) detection of papillomavirus (nested PCR technique using PGMY 09 11 primers, GP+5, GP+6) were performed. For analysis results, data categorized into two groups: (HIV+/HPV+) (HIV+/HPV-).Eighty-two women, aged between 35 49 years, participated this among whom 50% had HPV...
ABSTRACT The interest in red colorants by the food industry has been increasing recently due to its wide application many foods and beverages, also carcinogenic teratogenic effects of some synthetic dyes. Many ascomycetous fungi are able synthesize produce pigments, rendering them as alternative sources natural dyes that independent environmental conditions. Talaromyces islandicus TI01 was isolated from a marine-influenced environment suffering for decades anthropogenic actions body water....
ABSTRACT Background The bioactive metabolites production contributes to the resistance of fungi towards adverse environmental conditions. Some often have interesting health-promoting activities. This study addressed anti-tumoural properties Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods extract obtained polished environment strain P. was fermented, filtered, concentrated and lyophilized, giving rise Ethyl Acetate Extracellular Extract (EAE)....
Talaromyces islandicus TI01 was isolated from a marine-influenced environment that has been suffering for decades anthropogenic actions in its body of water.Broth microdilution technique performed to analyze the antimicrobial activity.For analysis cytotoxic activity, MTT [3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide] assay conducted.The chemical extract by LC/MS (liquid chromatography coupled mass spectrometry).The minimum bactericidal concentration (MBC) T. E. coli ATCC...