A5020331899- Research on Leishmaniasis Studies
- Phytochemicals and Antioxidant Activities
- Insect Pest Control Strategies
- Microbial Natural Products and Biosynthesis
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Bioactivity Studies
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
- Tannin, Tannase and Anticancer Activities
- Fungal Biology and Applications
- Biotechnology and Related Fields
- Tea Polyphenols and Effects
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Plant Toxicity and Pharmacological Properties
- Complementary and Alternative Medicine Studies
- Heavy Metals in Plants
- Public Health in Brazil
- Bee Products Chemical Analysis
- Medicinal Plant Extracts Effects
- Phytochemistry and Biological Activities
- Morinda citrifolia extract uses
- Chromatography in Natural Products
- Cancer Cells and Metastasis
- Cynara cardunculus studies
Fundação Oswaldo Cruz
2012-2025
Natura (Brazil)
2016
Instituto de Tecnologia e Pesquisa
2015
Carajurin is the main constituent of Arrabidaea chica species with reported anti-Leishmania activity. However, its mechanism action has not been described. This study investigated mechanisms carajurin against promastigote forms Leishmania amazonensis. was effective promastigotes IC50 7.96 ± 1.23 μg.mL-1 (26.4 µM), and cytotoxic concentration for peritoneal macrophages 258.2 1.20 (856.9 µM) after 24 h treatment. Ultrastructural evaluation highlighted pronounced swelling kinetoplast loss...
The state of Bahia is an important producer passion fruit, as well emerging on the Brazilian national scene a centre origin and diversity passionflowers. We aimed to identify bioactive compounds from Passiflora morifolia foetida. It was possible three flavonoids in P. foetida 8 molecules using HPLC-MS/MS technique. In total, 2 (two) were detected, but it not them crude extract leaves. morifolia, 1 (one) identified, only detected. Regarding antiparasitic activity exhibits better against...
Leishmaniasis is a complex of diseases caused by protozoa the genus Leishmania and affects millions people around world. Several species plants are used traditional communities for treatment this disease, among which Carapa guianensis Aubl. (Meliaceae), popularly known as andiroba. The objective present work was to conduct chemical study C. seed oil its limonoid-rich fractions, with aim identifying secondary metabolites, particularly limonoids, in addition investigating anti-Leishmania...
The present study aimed to evaluate the antileishmanial effect, mechanisms of action and association with miltefosine Vernonia brasiliana essential oil against Leishmania infantum promastigotes. This was obtained by hydrodistillation its chemical composition determined gas chromatography-mass spectrometry (GC–MS). activity L. promastigotes cytotoxicity on DH82 cells were evaluated MTT colorimetric assay. Ultrastructural alterations transmission electron microscopy. Changes in mitochondrial...
Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal viral diseases such measles chickenpox herpes. has several morphotypes recognized but little known about its chemical variability. In the present study anthocyanidin profile of A. collected two seasons (summer winter) have been examined their activity against Leishmania infection compared. High-performance liquid chromatography coupled diode-array detector...
Acknowledging the need of identifying new compounds for treatment leishmaniasis, this study aimed to evaluate, from in vitro trials, activity flavones Arrabidaea chica against L. amazonensis . The chromatographic profiles hydroethanolic extract and a flavone-rich fraction (ACFF) A. were determined by high-performance liquid chromatography coupled with diode-array UV-Vis detector (HPLC-DAD-UV) electrospray ionization mass spectrometry tandem (LC-ESI-MS-MS). luteolin ( 1 ) apigenin 2 ),...
Leishmaniasis is a group of neglected tropical diseases whose treatment with antimonials bears limitations and has changed little in over 80 years. Medicinal plants have been evaluated as therapeutic alternative for leishmaniasis. Arrabidaea chica popularly used wound healing antiparasitic agent, especially leishmanicidal agent. This study examined the activity crude extract (ACCE), an anthocyanidin-rich fraction (ACAF), three isolated anthocyanidins from A. chica: carajurin,...
The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate need developing alternative treatments. Several studies conducted with Morinda citrifolia have shown various biological activities, including antileishmanial activity, however its mechanisms action are unknown. This study aimed to analyze in vivo activity M. fruit juice (Noni) against Leishmania (Leishmania) amazonensis C57BL/6 mice. from Brazilian Amazon has same constitution other juices...
Euterpe oleracea (açaí) fruit has approximately 15% pulp, which is partly edible and commercialized, 85% seeds. Although açaí seeds are rich in catechins-polyphenolic compounds with antioxidant, anti-inflammatory, antitumor effects-almost 935,000 tons/year of discarded as industrial waste. This work evaluated the properties E. vitro vivo a solid Ehrlich tumor mice. The seed extract presented 86.26 ± 0.189 mg catechin/g extract. palm pulp extracts did not exhibit activity, while showed...
Species of the Vernonia genius are widely distributed across world. In traditional communities, they commonly used in popular medicine for treatment inflammatory diseases. The objective present study was to evaluate anti-inflammatory activity polysphaera Baker hydroalcoholic extract. A λ-carrageenan-induced paw edema and peritonitis model established BALB/c mice. vitro extract measured on LPS-stimulated RAW 264.7 cells. There no toxic effect mice or cells treated with Animals V. demonstrated...
Nowadays consumption of herbal medicines has been increasing worldwide.This uncontrolled use can present a serious risk to the health population because medicinal plants and represent complex mixtures substances that often interact with others have an adverse effect.This work intends emphasize importance pharmacovigilance in Brazil, order decrease threat effects drug interactions on contribute rational correct decision making by professionals working this area.Pharmacovigilance Brazil is...
As folhas de Arrabidaea chica são empregadas popularmente no tratamento cólica intestinal, diarreia, anemia, inflamação uterina e feridas cutâneas como cicatrizante. Tradicionalmente usadas também na produção matéria corante devido à presença 3-desoxiantocianidinas, constituintes químicos característicos da espécie. A. é descrita presente trabalho em termos botânica, farmacognosia, farmacologia toxicologia com vistas ao desenvolvimento um fitoterápico.
Açaí berry is a fruit from the tree commonly known as açaízeiro (Euterpe oleracea Mart.) originated Amazonian region and widely consumed in Brazil. There are several reports of anti-inflammatory activity its pulp few data about seed’s potential inflammation control. This work aimed to evaluate effect catechin-rich açaí extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells carrageenan-induced paw edema. The treatment with E. ethyl acetate (EO-ACET) was used an vitro model performed...
This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil.Ethyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. solid Ehrlich tumor model used for antitumor activity. Female Swiss mice divided into groups (n = 10/group) as follows: negative control (CTL-), treated with phosphate buffered solution; positive (CTL+), cyclophosphamide (25 mg/kg); extract...
Leishmaniasis is a complex disease caused by infection with different Leishmania parasites. The number of medications used for its treatment still limited and the discovery new drugs valuable approach. In this context, here we describe in vitro leishmanicidal activity silico interaction between trypanothione reductase (TryR) (-)-5-demethoxygrandisin B from leaves Virola surinamensis (Rol.) Warb. compound was isolated V. leaves, plant found Brazilian Amazon, it characterized as...
Doenças negligenciadas impõem um fardo humano, social e econômico devastador a mais de 1 bilhão pessoas em todo o mundo. Embora existam ferramentas para controlar até mesmo eliminar muitas dessas doenças, novos produtos terapêuticos precisam urgentemente ser desenvolvidos. Produtos derivados da biodiversidade são uma alternativa à busca medicamentos. Este estudo buscou apresentar por meio análise bibliométrica cenário global desenvolvimento plantas medicinais destinadas ao tratamento doenças...
Este artigo objetiva avaliar os fenólicos totais e a atividade antioxidante do extrato preparado fungo Penicillium purpurogenum, obtido de um ambiente marinho poluído São Luís-MA. A pesquisa foi realizada na Laguna da Jansen localizada no município Luís, Maranhão, Brasil. Foram realizadas 4 coletas sedimento período maio setembro 2017, matutino. As amostras foram obtidas uma profundidade até 73,5 cm com auxílio draga metálica. identificação seguiu metodologias isolamento posterior preparo...
Este artigo objetiva o isolamento, identificação e triagem fitoquímica de um extrato preparado do fungo Penicillium purpurogenum, obtido ambiente marinho poluído São Luís-MA. A pesquisa foi realizada na Laguna da Jansen localizada no município Luís, Maranhão, Brasil. Foram realizadas 4 coletas sedimento período maio a setembro 2017, matutino. As amostras foram obtidas uma profundidade até 73,5 cm com auxílio draga metálica. seguiu metodologias isolamento dos extratos preparados por...
O presente trabalho realizou uma prospecção tecnológica a partir de patentes para identificação derivados das plantas medicinais o tratamento da tuberculose. uso como fonte informação pode otimizar desenvolvimento novos medicamentos A novas tecnologias foi realizada pelo portal Orbit Intelligence, utilizando sentença “(+tuberculos+)/TI/AB AND (A61K OR A61P)/IPC PRD >= 2015” estratégia pesquisa. Foram identificadas 16 famílias apresentando com evidência eficácia in vitro contra cepas...
Talaromyces purpurogenus is a fungus species widely found in the marine environment. When hostile environment, it produces series of secondary metabolites with important biotechnological potential, such as meroterpenoids. In our previous report, we demonstrated that culture broth ethyl acetate extract from T. reduced cellular infiltration lymphoid organs and circulating levels TNF-α. To elucidate this anti-inflammatory effect, work aimed to study isolated marine-polluted environment...
O presente trabalho realizou uma prospecção tecnológica a partir de patentes para identificação derivados das plantas medicinais o tratamento da tuberculose. uso como fonte informação pode otimizar desenvolvimento novos medicamentos A novas tecnologias foi realizada pelo portal Orbit Intelligence, utilizando sentença “(+tuberculos+)/TI/AB AND (A61K OR A61P)/IPC PRD >= 2015” estratégia pesquisa. Foram identificadas 16 famílias apresentando com evidência eficácia in vitro contra cepas...
Anthocyanidins are found in nature mainly as pelargonidin, cyanidin, peonidin, delphinidin, petunidin, and malvidin derivatives. These compounds free or glycoside derivatives which responsible for the color (red, blue, violet) of some foods attracting seed dispersers. They grouped into 3-hydroxyanthocyanidins, 3-deoxyanthocyanidins (3D-anth), O-methylated anthocyanidins. A new method was developed validated to quantify 3D-anth plant-rich extracts. To test method, Arrabidaea chica Verlot...
ABSTRACT Background The bioactive metabolites production contributes to the resistance of fungi towards adverse environmental conditions. Some often have interesting health-promoting activities. This study addressed anti-tumoural properties Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods extract obtained polished environment strain P. was fermented, filtered, concentrated and lyophilized, giving rise Ethyl Acetate Extracellular Extract (EAE)....