A5101945456- Occupational Health and Burnout
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Natural product bioactivities and synthesis
- Venomous Animal Envenomation and Studies
- Healthcare during COVID-19 Pandemic
- Phytochemistry Medicinal Plant Applications
- Healthcare and Venom Research
- Traditional and Medicinal Uses of Annonaceae
- Agriculture and Rural Development Research
- Pomegranate: compositions and health benefits
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Immunotherapy and Immune Responses
- Trypanosoma species research and implications
- Chemical Reaction Mechanisms
- Adenosine and Purinergic Signaling
- Bee Products Chemical Analysis
- Dental materials and restorations
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Bioactive Natural Diterpenoids Research
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
- Health, Nursing, Elderly Care
Universidade Federal do Maranhão
2016-2025
Universidade Federal de Mato Grosso do Sul
2025
Universidade Federal do Paraná
2017-2025
Centro Universitário Curitiba
2025
Centro Universitário do Pará
2025
Universidad de Costa Rica
2025
Fundação Oswaldo Cruz
2017-2022
National Institute of Epidemiology
2022
Amazon (United States)
2022
Centro Nacional de Epidemiología
2021
Abstract Immune deviation induced by breast cancer may have a role in current failures of dendritic cell-based immunotherapy. DCs orchestrate immune responses contributing to the pattern response developed. In cancer, play dysfunctional induction CD4+CD25+Foxp3+ Tregs, evasion. We show here that Mo-DCs from patients an altered phenotype and induce preferentially phenomenon occurred regardless DC maturation stimulus (sCD40L, cytokine cocktail, TNF-α, LPS). The low proliferation allogeneic...
To analyze nurses' competencies with regard to their work in post-operative heart surgery and the strategies implemented mobilize these competencies.This was an exploratory study a qualitative approach methodological design of collective case study. It carried out three units, consisting 18 nurses. Direct observation semi-structured interviews were employed collect data. Data construed through thematic analysis.nine found, as follows: theoretical-practical knowledge; high-complexity nursing...
A Doença de Parkinson (DP) é uma condição neurodegenerativa progressiva marcada pela perda neurônios dopaminérgicos, resultando em sintomas motores como tremores, rigidez e bradicinesia, além não-motores distúrbios do sono depressão. O tratamento inclui abordagens farmacológicas, a levodopa outros medicamentos que aumentam os níveis dopamina, intervenções não-farmacológicas, exercício físico fisioterapia. importância da toxina botulínica na DP reside sua capacidade proporcionar alívio...
Mechanisms involved in severe P. vivax malaria remain unclear. Parasite polymorphisms, parasite load and host cytokine profile may influence the course of infection. In this study, we investigated circumsporozoite protein (CSP) polymorphisms on patients with malaria. A cross-sectional study was carried out three cities: São Luís, Cedral Buriticupu, Maranhão state, Brazil, areas high prevalence vivax. Interleukin (IL)-2, IL-4, IL-10, IL-6, IL-17, tumor necrosis factor alpha (TNF-α, interferon...
Pilocarpus species have been exploited as the only source of imidazole alkaloid pilocarpine (used in glaucoma treatment), since its isolation up to present. Almost all Pilocarpusspecies are native from Brazil. Because medicinal importance pilocarpine, several them path extinction. Other secondary metabolites, such coumarins, flavonoids and terpenes, were described for Pilocarpusspecies. In this review other than isolated their biological activities compiled. Although variety structures...
Currently known risk factors explain only a small fraction of preterm birth (PTB). Previous PTB is one the most important predictors. However, this information not available in primiparous women. Few studies have looked at associations between regulatory cytokine expression (RCE) and results are conflicting.To investigate association RCE-Interleukin 10 (IL-10) Transforming Growth Factor β (TGF-β)-with PTB, to assess whether bacterial vaginosis (BV) involved relationship.This was case-control...
The babassu palm tree is native to Brazil and most densely distributed in the Cocais region of state Maranhão, northeastern Brazil. In addition industrial use refined oil, milk, unrefined oil nuts natura are used by families from several communities African descendants as one principal sources food energy. objective this study was evaluate effects on microvascular permeability leukocyte-endothelial interactions induced ischemia/reperfusion using hamster cheek pouch microcirculation...
Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host’s defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses sepsis, but its other pathogenic diseases has never been addressed. We investigated the effects capsazepine, TRPV1 antagonist, C57BL/6 mice received 10 5 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. Noninfected were used as controls....
Abstract Monosodium l -glutamate (MSG)-induced obesity is a useful model for non-alcoholic fatty liver disease (NAFLD) studies. However, there limited data on its initiation and progression. Thus, this study aimed to characterize the onset of metabolic histopathological features NAFLD progression steatohepatitis (NASH) in model. To perform study, Swiss mice pups were neonatally injected with MSG (4 g/kg/day, s.c.) or equiosmolar saline followed up 60, 120 180 days old. At each age, blood,...
Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018. Plasmodium falciparum represents the species that causes most human due to severe malaria. In addition, studies prove resistance of P. drugs used treat malaria, making search new with antiplasmodial potential necessary. this context, literature describes snake venoms as rich source molecules microbicidal potential, including phospholipases A2 (PLA2s). sense, present study aimed isolate basic PLA2s from...