A5067943824- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Lanthanide and Transition Metal Complexes
- Crystal structures of chemical compounds
- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Inorganic and Organometallic Chemistry
- Synthesis and biological activity
- Metal-Catalyzed Oxygenation Mechanisms
- Organometallic Compounds Synthesis and Characterization
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Synthesis of Tetrazole Derivatives
- Electrochemical sensors and biosensors
- Photochemistry and Electron Transfer Studies
Universidade Federal de São Carlos
2016-2025
Universidade Federal de Goiás
2019-2023
Universidad San Carlos
2019
Center for Effective Philanthropy
2015
Universidade Estadual Paulista (Unesp)
2002-2013
Universidade de São Paulo
1980-2013
Universidade Estadual de Maringá
2013
Universidade Federal de Minas Gerais
2005-2006
University of Windsor
2005
Universidade Federal do Paraná
2005
In this paper, aggregated CaWO4 micro- and nanocrystals were synthesized by the co-precipitation method processed under microwave-assisted hydrothermal/solvothermal conditions (160 °C for 30 min). According to X-ray patterns, all crystals exhibited only scheelite-type tetragonal structure. The data obtained Rietveld refinements revealed that oxygen atoms occupy different positions in [WO4] clusters, suggesting presence of lattice distortions. crystal shapes as well its crystallographic...
A series of copper(I)–phosphine polypyridyl complexes have been investigated as potential antitumor agents. The [Cu(PPh3)2dpq]NO3 (2), [Cu(PPh3)2dppz]NO3 (3), [Cu(PPh3)2dppa]NO3 (4), and [Cu(PPh3)2dppme]NO3 (5) were synthesized by the reaction [Cu(PPh3)2NO3] with respective planar ligand under mild conditions. These copper fully characterized elemental analysis, molar conductivity, FAB-MS, NMR, UV–vis, IR spectroscopies. Interactions between these DNA using various spectroscopic techniques...
Over the past several decades, much attention has been focused on ruthenium complexes in antitumor therapy. Ruthenium is a transition metal that possesses advantages for rational drug design and biological applications. In present study, five containing amino acids were studied vitro to determine their activity against sarcoma-180 tumor cells. The cytotoxicity of was evaluated by an MTT assay, mechanism action investigated. results demonstrated inhibited growth S180 cell line, with IC50...
Chiral molecules in nature are involved many biological events; their selectivity and specificity make them of great interest for understanding the behavior bioactive molecules, by providing information about chiral discrimination. Inspired these conformational properties, we present design synthesis novel platinum(II) complexes featuring phosphine chloroquine ligands with general formula [PtCl(P)2(CQ)]PF6 (where (P)2 = triphenylphosphine (PPh3) (5), 1,3-bis(diphenylphosphine)propane (dppp)...
Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh3)2(bipy)]PF6 (PPh3 = triphenylphosphine; bipy 2,2'-bipyridine) enhanced cytotoxicity different cancer cells, assessed its apoptosis induction action human colon carcinoma HCT116 cells. The was characterized by infrared, cyclic...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype. The high rate of metastasis associated to the fact that these cells frequently display multidrug resistance, make treatment metastatic disease difficult. Development antitumor metal-based drugs was started with discovery cisplatin, however, severe side effects represent limitation for its clinical use. Ruthenium (Ru) complexes different ligands have been successfully studied as prospective drugs. In this work, we...
Eight Ru(<sc>ii</sc>) complexes were synthesized. The activities against MDA-MB-231 cells include anti-migration, arrest at the sub-G1 phase and cell death by apoptosis.
In this study, half-sandwich Ru(II) complexes containing acylthiourea ligands of the general type [Ru(η6-p-cymene)(PPh3)(S)Cl]PF6 (1m–6m) and [Ru(η6-p-cymene)(PPh3)(S–O)]PF6 (1b–6b) where S/S–O = N',N'-disubstituted were synthesized characterized (via elemental analyses, IR spectroscopy, 1H NMR 13C{1H} X-ray diffractometry), their cytotoxic activity was evaluated. The different coordination modes ligands, monodentately via S bidentately S,O (1b–6b), to ruthenium modulated from synthetic...
Searching for new copper compounds which may be useful as antitumor drugs, a series of [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline, L-dipeptide: Gly-Val, Gly-Phe, Ala-Gly, Ala-Ala, Ala-Phe, Phe-Ala, Phe-Val and Phe-Phe) complexes were synthesized characterized. To interpret the experimental IR spectra, [Cu(ala-gly)(batho)] was modelled in gas phase using DFT at B3LYP/LANL2DZ level theory calculated vibrational frequencies analyzed. Solid-state characterization is...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, crystal structure, electrochemical, and spectroelectrochemical properties of the new manganese(III) complex [MnIII(BBPEN)][PF6] [H2BBPEN = N,N'-bis(2-hydroxybenzyl)-N,N'-bis(2-methylpyridyl)ethylenediamine]Ademir Neves, Sueli M. D. Erthal, Ivo Vencato, Augusto S. Ceccato, Yvonne P. Mascarenhas, Otaciro R. Nascimento, Manfredo Horner, Alzir A. BatistaCite this: Inorg. Chem. 1992, 31, 23, 4749–4755Publication Date (Print):November 1,...
Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense interest due to its anticancer characteristics target the oxidative stress. In present paper, two novel piplartine-containing ruthenium complexes [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) were synthesized investigated for their cellular molecular responses on cancer cell lines. We found both are more potent than metal-free piplartine in panel of lines monolayer...