A5044502316- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Ferrocene Chemistry and Applications
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Trace Elements in Health
- Magnetism in coordination complexes
- Click Chemistry and Applications
- Crystal structures of chemical compounds
- HIV/AIDS drug development and treatment
- Organometallic Compounds Synthesis and Characterization
- Crystallography and molecular interactions
- Trypanosoma species research and implications
- Fungal Infections and Studies
- Chemical Synthesis and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metal-Catalyzed Oxygenation Mechanisms
- Oxidative Organic Chemistry Reactions
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Heavy Metal Exposure and Toxicity
Universidade Federal de Juiz de Fora
2017-2025
Instituto Venezolano de Investigaciones Científicas
2007-2022
Instituto Nacional de Metrologia, Qualidade e Tecnologia
2015-2021
Rede de Química e Tecnologia
2018
Centro de Ensino Superior de Juiz de Fora
2017-2018
Murdoch University
2012-2017
The University of Western Australia
2009-2012
Purdue University West Lafayette
2004
Institut de Médecine Tropicale du Service de Santé des Armées
2004
About half of the world's population is at risk malaria, and in tropical countries it remains a major cause morbidity death children. Drug resistance to current established antimalarial drugs such as chloroquine driving rise malaria-attributed deaths. In mid-1990s, two groups—in France Venezuela—probed potential contribution organometallic analogues means discovering new drugs. present review, key topics antimalarials are outlined using examples from literature. The interdisciplinary...
A series of copper(I)–phosphine polypyridyl complexes have been investigated as potential antitumor agents. The [Cu(PPh3)2dpq]NO3 (2), [Cu(PPh3)2dppz]NO3 (3), [Cu(PPh3)2dppa]NO3 (4), and [Cu(PPh3)2dppme]NO3 (5) were synthesized by the reaction [Cu(PPh3)2NO3] with respective planar ligand under mild conditions. These copper fully characterized elemental analysis, molar conductivity, FAB-MS, NMR, UV–vis, IR spectroscopies. Interactions between these DNA using various spectroscopic techniques...
Chloroquine free base (CQ) reacts with [Rh(COD)Cl]2 (COD = 1,5-cyclooctadiene) and RuCl3·3H2O/Zn to yield Rh(COD)(CQ)Cl (1) [RuCl2(CQ)]2 (2), respectively. The two novel metal−CQ complexes, which were characterized mainly by 1D 2D NMR spectroscopy, tested against Plasmodium berghei. in vitro activity of 1 was comparable that chloroquine diphosphate (CQDP), whereas 2 about 5 times more active. In vivo tests at equivalent concentrations CQ, CQDP reduced the parasitemia 55%, while for complexes...
Reaction of AuPPh3Cl with chloroquine (CQ) and KPF6 leads to the new complex [Au(PPh3)(CQ)]PF6 (1) which was found be considerably more active than CQ diphosphate other previously reported metal−CQ complexes against two chloroquine-resistant strains Plasmodium falciparum in vitro also berghei vivo.
Chiral molecules in nature are involved many biological events; their selectivity and specificity make them of great interest for understanding the behavior bioactive molecules, by providing information about chiral discrimination. Inspired these conformational properties, we present design synthesis novel platinum(II) complexes featuring phosphine chloroquine ligands with general formula [PtCl(P)2(CQ)]PF6 (where (P)2 = triphenylphosphine (PPh3) (5), 1,3-bis(diphenylphosphine)propane (dppp)...
A number of new Au(I) and Au(III) complexes chloroquine (CQ) have been prepared, characterized, evaluated in vitro against several strains Plasmodium falciparum. [(CQ)Au(PPh3)][NO3] (2) was synthesized by reaction AuCl(PPh3) with AgNO3 followed treatment CQ. Similar reactions AuCl(PR3) (R = Me, Et) KPF6 CQ yielded [(CQ)Au(PMe3)][PF6] (3), [(CQ)Au(PEt3)][PF6] (4), respectively. KAuCl4 reacted to produce the complex [(CQ)2Au(Cl)2]Cl (5), which turn formed [(CQ)Au(Cl)(SR)(Et2O)]Cl (6)...
To ascertain the bioinorganic chemistry of metals conjugated with quinones, complexes [Ag(ATV)(PPh3)2] (1), [Au(ATV)(PPh3)]·2H2O (2), and [Cu(ATV)(PPh3)2] (3) were synthesized by coordination antimalarial naphthoquinone atovaquone (ATV) to starting materials [Ag(PPh3)2]NO3, [Au(PPh3)Cl], [Cu(PPh3)2NO3], respectively. These characterized analytical spectroscopical techniques. X-ray diffraction single crystals precisely confirmed mode ATV metals, which was monodentate or bidentate, depending...
The complexes [Cu(CTZ)(4)]Cl(2).2H(2)O (1), [Cu(CTZ)Cl(2)](2) (2), [Cu(KTZ)(3)Cl(2)] (3), and [Cu(KTZ)Cl(2)](2).2H(2)O (4) were prepared by reaction of CuCl(2) with CTZ KTZ (where = 1-[[(2-chlorophenyl)diphenyl]methyl]-1H-imidazole cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine), respectively, in acetonitrile at different ligand to metal molar ratios. Gold [Au(PPh(3))(CTZ)]PF(6) (5) [Au(PPh(3))(KTZ)]PF(6).H(2)O (6)...
Malaria still has significant impacts on the world; particularly in Africa, South America and Asia where spread over several millions of people is one major causes death. When chloroquine diphosphate (CQDP) lost its efficiency as a first-line anti-malarial drug, this was setback effective control malaria. Currently, malaria treated with combination two or more drugs different modes action to provide an adequate cure rate delay development resistance. Clearly, new non-toxic drug urgently...