A5068664177- Trypanosoma species research and implications
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Glutathione Transferases and Polymorphisms
- Celiac Disease Research and Management
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Cholinesterase and Neurodegenerative Diseases
- Viral Infections and Vectors
- Tuberculosis Research and Epidemiology
- Psoriasis: Treatment and Pathogenesis
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
- Genetic Associations and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune Bullous Skin Diseases
- Olfactory and Sensory Function Studies
- Spondyloarthritis Studies and Treatments
- Myasthenia Gravis and Thymoma
- Microscopic Colitis
- Public Health and Environmental Issues
- Hemoglobin structure and function
- Diabetes, Cardiovascular Risks, and Lipoproteins
Instituto Venezolano de Investigaciones Científicas
2014-2024
Unidad de Artritis y Reumatismo
2023
Hospital Clínico Universitario de Caracas
2023
University of Zulia
2020
Among the several hypothesis postulated to explain pathogenesis of severe dengue disease, model immunopathogenesis is most supported one with a likely important role played by cascade cytokines. This work describes single-nucleotide polymorphism tumor necrosis factor (TNF)-alpha, interferon-gamma, interleukin (IL)-6, transforming growth factor-beta1, and IL-10 in patients virus infections analyzes their relation clinical manifestations disease. Because cytokine gene polymorphisms affect...
Abstract Aims: Autoimmune hepatitis (AIH) is a progressive liver disease characterized by the presence of circulating autoantibodies, hypergammaglobulinaemia and favourable response to immunosuppressive treatment. Although pathogenesis type 1 AIH unknown, susceptibility partially determined genes linked class II region major histocompatibility complex. Type has been associated with DRB1 * 03, 04 DRB3 alleles in European North American Caucasians, 0405 Japanese, 0404 Mexican, 1301 Argentinean...
Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of innate adaptive immunity against Mycobacterium tuberculosis , associations between susceptibility to polymorphisms in genes NRAMP VDR have been sought geographically diverse populations. We investigated NRAMP1 gene with TB Venezuelan population. The results suggest absence any association variants FokI, ApaI TaqI tuberculosis. In contrast, 3′UTR were associated M. infection,...
Abstract The two basic forms of autoimmune intraepidermal blistering diseases, pemphigus vulgaris (PV) and foliaceus (PF), affect different layers the skin, have symptoms target antigens. We defined human leukocyte antigen (HLA)‐DRB1‐DQB1 alleles haplotypes in a case–control study 66 non‐Jewish patients attending public reference Hospital over past 10 years. control group consisted 101 matched individuals tested also by medium to high‐resolution polymerase chain reaction‐sequence‐specific...
Several studies have reported increased oxidation of lipids, proteins and DNA in the brains patients with Alzheimer disease (AD). Moreover, these display differences activity polymorphisms genes encoding enzymes GST (T1, M1) MnSOD. For reasons, we designed a study variability GSTT1, GSTM1, MnSOD healthy AD groups from Venezuelan population. We included 179 unrelated subjects classified as either (n = 79) or individuals 100). Presence absence GSTT1/GSTM1 was determined using PCR-SSP, APOE...
The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. objective present study was to estimate distribution APOE alleles five Venezuelan communities: two Amerindian tribes (Bari Yucpa), one Negroid population from Curiepe, Caucasoid Colonia Tovar Mestizo urban living Caracas. APOE*3 allele most common all populations studied. However, a significant increase APOE*2 frequency...
This study represents the first report on distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all are present this population. Frequency inhibitory killer cell immunoglobulin-like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs low frequencies (0.11-0.29), KIR2DS4 (0.68). Forty-five different genotypes were identified, with a predominance three found 50.7% population which 25.9%...
Although the number of people infected with T. cruzi is on rise, host genetic and immune components that are crucial in development Chagas disease have been discovered. We investigated frequency polymorphisms gene encoding haptoglobin patients chronic disease. The results suggest while HP1-1 genotype may confer protection against infection due to rapid metabolism Hp1-1-Hb complex its anti-inflammatory activity, presence HP2-2 increase susceptibility towards a condition slow Hp2-2-Hb complex,...
Purpose: Fasting or postprandial hypertriglyceridemia is considered an independent cardiovascular disease (CVD) risk factor. The intestinal fatty acid binding protein (FABP2) involved in the intracellular transport and metabolism of acids. presence Ala54Thr polymorphism FABP2 gene appears to be hypertriglyceridemia. We explored possible association with fat intolerance apparently healthy, fasting, normolipidemic subjects normal body-mass index without diabetes. Methodology: A total 158...
Rheumatoid arthritis is an autoimmune and inflammatory disease that predominantly affects the diarthrodial joints. In this pathology, environmental or behavioral factors can act in synergy with genetic predisposition, accelerating onset severity of disease. This link between environment genome mediated by epigenetic marks on deoxyribonucleic acid, including its methylation, histone modification, noncoding ribonucleic acid-mediated regulation. Epigenetics generate heritable phenotypic...
Prostate cancer is the third cause of death in men Western hemisphere and second Zulian from Venezuela.To determine whether polymorphisms 308 238 tumor necrosis factor alpha (TNF-α) gene are associated with prostate cancer.The DNA that was extracted peripheral blood 40 patients prostatic specific antigen controls amplified by PCR plus digestion enzymes NcoI MspI.In patients, genotypes TNF-α-238 polymorphism were observed 90% GG 10% GA; controls, 97.5% 2.5% GA, odds ratio (OR) = 4,000 for GA....
Celiac disease (CD) is a complex condition, whose main genetic determinant involves HLA molecules, specifically the HLA-DQ2 and/or HLA-DQ8 heterodimers. Nevertheless, frequency of alleles encoding those molecules has not been reported in Venezuelan celiac patients. Therefore, aim our study was to evaluate HLA-DQB1 individuals with symptoms suggestive CD and define diagnostic markers condition population.A cross-sectional included 516 CD. Molecular typing locus performed using polymerase...
Previous studies carried out in an endemic semiarid region northwest of Venezuela at Falcon State have shown a prevalence 15.4/1000 chromoblastomycosis following traumatisms with xenophile vegetation infected Cladophialophora carrionii. We performed high-resolution DNA typing human leukocyte antigen (HLA)-A, -B and -C major histocompatibility complex class I chain related gene A (MICA) alleles segregation analysis 49 members one extended family 12 affected individuals, who lived for...
Persistent olfactory impairment (POI) and dysgeusia are lingering symptoms following recovery from Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. These symptoms, along with neurological changes affecting mood, anxiety, cognitive function, sleep, have significant public health implications. However, the cause of these is still unknown. For this reason, we investigated whether presence certain proteins, such as amyloid Aβ α-synuclein in mucosa tissue POI patients, could be...