A5034730917- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Biomarkers in Disease Mechanisms
- Melanoma and MAPK Pathways
- Parathyroid Disorders and Treatments
- Cancer Risks and Factors
- Cardiovascular Health and Disease Prevention
- Bone health and treatments
- Vitamin D Research Studies
- Computational Drug Discovery Methods
- Respiratory Support and Mechanisms
- Accounting and Financial Management
- Peripheral Artery Disease Management
- Infant Nutrition and Health
- Pluripotent Stem Cells Research
- Antifungal resistance and susceptibility
- Pesticide Exposure and Toxicity
- Bone and Joint Diseases
- Cardiovascular Health and Risk Factors
- Business, Education, Mathematics Research
- Bone health and osteoporosis research
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
Universidad Regional Autónoma de Los Andes
2024
European Environment Agency
2024
Colorado Permanente Medical Group
2023-2024
Kaiser Permanente
2012-2023
Florida College
2023
University of Florida
2023
City Of Hope National Medical Center
2023
Hospital Provincial de Rosario
2022
Maastricht University
2022
Acorda Therapeutics (United States)
2022
Since the late twentieth century, “citizen science” has become an increasingly fashionable label for a growing number of participatory research activities. This paper situates origins and rise term contextualises within broader history public participation in science. It analyses critically current promises — democratisation, education, discoveries emerging discourse offers new framework to better understand diversity epistemic practices involved these projects. Finally, it maps historical,...
<h3>Background</h3> Psychological functioning is an important determinant of health outcomes in chronic lung disease. To better define the role anxiety obstructive pulmonary disease (COPD), a study was conducted inter-relations between and COPD large cohort subjects with matched control group. <h3>Methods</h3> Data were used from FLOW (Function, Living, Outcomes, Work) patients (n=1202) controls without (n=302). Anxiety measured using subscale Hospital Depression Scale. <h3>Results</h3>...
<h3>Background</h3> Although chronic obstructive pulmonary disease (COPD) is a common cause of death and disability, little known about the effects socioeconomic status (SES) race–ethnicity on health outcomes. <h3>Methods</h3> The aim this study to determine independent impacts SES COPD severity status, functional limitations acute exacerbations among patients with access healthcare. Data were used from Function, Living, Outcomes Work cohort 1202 Kaiser Permanente Northern California Medical...
Epigenetic regulation serves as the basis for stem cell differentiation into distinct types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested hypothesis that chromatin organization affects lineage potential of cells and manipulation dynamics influences function. Using nuclease sensitivity assays, found a progressive decrease in digestion among pluripotent embryonic (ESCs), multipotent hematopoietic (HSCs), mature cells. Quantitative...
Objective Helicobacter pylori causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk cancer. Research on pathogenesis this infection would strongly benefit from an authentic human in vitro model. Design Antrum-derived glands surgery specimens served establish polarised epithelial monolayers via a transient air–liquid interface culture stage study cross-talk H. and adjacent stroma. Results The resulting ‘mucosoid cultures’, so named because...
Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth tumors but often leads to emergence slowly dividing persister cells, which constitute a reservoir for selection drug-resistant clones. In BRAFV600E melanomas, RAF and MEK inhibitors efficiently block signaling, cells emerge. Here, we show that escape drug-induced cell-cycle arrest via brief, sporadic ERK pulses generated by transmembrane receptors factors operating an autocrine/paracrine manner....
Breast arterial calcification (BAC), a common incidental finding in mammography, has been shown to be associated with angiographic coronary artery disease and cardiovascular (CVD) outcomes. We aimed (1) examine the association of BAC presence quantity hard atherosclerotic CVD (ASCVD) global CVD; (2) ascertain model calibration, discrimination reclassification ASCVD risk; (3) assess joint effect 10-year pooled cohorts equations risk on ASCVD.
We sought to quantify the impact of respiratory muscle and lower extremity strength on exercise capacity function (LEF) in patients with chronic obstructive pulmonary disease (COPD).In 828 persons COPD, we assessed reduced (maximum inspiratory pressure, MIP) (quadriceps strength, QS) (6-minute walk test, 6MWT), LEF (short physical performance battery). Multiple regression analyses taking into account key covariates, including lung smoking, tested associations between functional capacity.For...
Statins are a commonly prescribed cholesterol lowering drug class that can increase the risk of new-onset diabetes (NOD). To investigate molecular mechanisms underlying this effect, we generated human induced pluripotent stem cells (iPSCs) from individuals identified electronic health records Kaiser Permanente Northern California who were susceptible to developing NOD after statin initiation or controls maintained stable fasting glucose on treatment. RNA-seq analysis iPSCs incubated with...
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance surface integrity oral mucosa and enhance healing gastrointestinal by process called restitution. TFF comprises gastric peptides (TFF1), spasmolytic peptide (TFF2), intestinal trefoil factor (TFF3). have an important necessary epithelial restitution within tract. Significant amounts present human milk. This study aimed to determine possible correlation between TFF3 isolated from...
<p><strong>Background: </strong>We examined the role of language and culture in interactions between Spanish-speaking Latino patients with poorly controlled diabetes – a fast-growing population United States - their primary care providers. </p><p><strong>Methods: conducted four focus groups 36 non-US born elevated HbA1c. Participants were insured health plan members either English-speaking (2 groups) or Moderated discussions focused on visit preparation,...
Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks iPSCs derived from diverse donors. However, there not yet standardized guidelines qualifying these cell lines, i.e., distinguishing between bona fide human iPSCs, somatic cells, imperfectly reprogrammed cells. Here, we report the establishment...
Millions of people worldwide are living in areas where ozone (O3) concentrations exceed health standards (an hourly average 235 micrograms/m3/0.12 ppm, not to be exceeded more than once per year). Ozone induces acute nasal inflammatory responses and significant epithelial lesions experimental animals humans. To determine the effects a 15-day exposure an urban polluted atmosphere with O3 as main pollutant, we studied population healthy, young males newly arrived southwest metropolitan Mexico...
Abstract Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR cells delivered weekly into lateral cerebral ventricles, identifying clonal expansion endogenous CAR-negative CD8 + in cerebrospinal fluid (CSF) over time. Additionally, five evaluable disease response,...
Mitochondrial dysfunction contributes to many forms of peripheral and central nervous system degeneration. Therapies that protect mitochondrial number function have the potential impact progression conditions such as diabetic neuropathy. We therefore assessed indices in dorsal root ganglia (DRG) brain cortex Zucker fatty (ZDF) rat model type 2 diabetes tested therapeutic a neurogenic compound, NSI-189, on both neurological dysfunction. ZDF rats were maintained for 16 weeks untreated before...
<b><i>Background:</i></b> Although chronic obstructive pulmonary disease (COPD) is a major cause of disability worldwide, its determinants remain poorly defined. <b><i>Objective:</i></b> We hypothesized that both and extra-pulmonary factors would predict prospective disablement across hierarchy activities in persons with COPD. <b><i>Methods:</i></b> Six hundred nine participants were studied at baseline (T&#8320;)...
In COPD, body composition studies have focused primarily on low BMI. We examined obesity (BMI ≥ 30 kg/m2) as a risk factor for poor function and longitudinal functional decline. Data from cohort of adults with COPD (n = 1096) an age- sex-matched comparison group collected in two in-person visits ∼49 months apart were analyzed. Two measures functioning examined: six-minute walk distance (6MWD) Short Physical Performance Battery (SPPB). Multivariate regression analyses relationships...
The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act platelets and reduce incidence cardiovascular diseases. Since significant differences platelet function been reported between human animal platelets, a study focusing on effect A. extracts activation necessary.The compounds an ethanolic extract underwent bio-guided fractionation were used vitro aggregation assays to...
While peripheral neuropathy is the most common complication of long-term diabetes, cognitive deficits associated with encephalopathy and myelopathy also occur. Diabetes a risk factor for Alzheimer disease (AD) increases progression from mild impairment to AD. The only current recommendation preventing or slowing maintain close glycemic control, while there no central nervous system disorders. NSI-189 new chemical entity that when orally administered promotes neurogenesis in adult...
Human breast milk is the best form of nourishment for infants during first year life. It composed by a complex mixture carbohydrates, proteins and fats. Breast provides nutrients bioactive factors that themselves modulate maturation development gastrointestinal tract. Many studies have shown it protection against tract inflammation. In this sense, study aimed to evaluate effect human lipids on epithelial intestinal cells (Caco-2) cytokine regulation fatty acid transporter protein (FATP)...
Millions of people worldwide are living in areas where ozone (03) concentrations exceed hea standards (anihourl average 235 pgmim30.12ppm, not t" be eceede more than once per year).Ozone induces acute nasal inflammatory rponses and Significant epithelial lesions experimental animals humans.To determine the effects a 15-day exposure to an urban pollutdatimospher.with 03 as..the main pett, studied healthy, young males niewly arrived soutiwest metropolitan Mexico City (SWMMC).The study included...