A5064506130- Glioma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Tumors and Oncological Cases
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Liver physiology and pathology
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Chromatin Remodeling and Cancer
- Cellular Mechanics and Interactions
- Medical and Biological Sciences
- Lung Cancer Research Studies
City of Hope
2019-2024
City Of Hope National Medical Center
2020-2024
Thomas Jefferson University Hospital
2020
Marche Polytechnic University
2020
University of Bologna
2020
The University of Texas Health Science Center at Houston
2020
McGill University
2020
University of Thessaly
2005-2020
Anna Needs Neuroblastoma Answers
2020
National and Kapodistrian University of Athens
2020
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that in isogenic cells correlated with increased expression of integrin β4 (ITGB4), component the focal adhesion complex. Silencing ITGB4 tolerant improved sensitivity, while overexpressing enhanced tolerance by supporting AKT-mTOR bypass signaling. Chronic treatment induced WNT and activated WNT/β-catenin signaling pathway. Thus, silencing both β-catenin significantly...
Abstract Anaplasia may be identified in a subset of tumors with presumed pilocytic astrocytoma ( PA ) component or piloid features, which associated aggressive behavior, but the biologic basis this change remains unclear. Fifty‐seven resections from 36 patients (23 M, 13 F, mean age 32 years, range 3–75) were included. A clinical diagnosis NF 1 was present 8 (22%). Alternative lengthening telomeres ALT assessed by telomere‐specific FISH and/or CISH . combination immunohistochemistry, DNA...
This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance lung squamous cell carcinoma (LUSC). The expression ITGB4 is found to be high all LUSC subtypes, but impact on overall patient survival varies by subtype. Cancer stem cells (CSCs) isolated from patients were resistant cisplatin, knocking down or sensitized them cisplatin. Carfilzomib (CFZ) synergized with cisplatin suppressed CSC growth inhibiting expression. Additionally, CFZ...
Tumor heterogeneity and cisplatin resistance are major causes of tumor relapse poor survival. Here, we show that in lung cancer, interaction between paxillin (PXN) integrin β4 (ITGB4), components the focal adhesion (FA) complex, contributes to resistance. Knocking down PXN ITGB4 attenuated cell growth improved sensitivity, both 2D 3D cultures. independently regulated expression several genes. In addition, they also common genes including USP1 VDAC1, which required for maintaining genomic...
Abstract Potential roles of euchromatic histone methyltransferase 2 (EHMT2 or G9a) in invasion and metastasis are not well understood non–small cell lung cancer (NSCLC). Here, we investigated the effect underlying mechanisms G9a therapeutic implications targeting NSCLC. Overexpression significantly enhanced vitro proliferation invasion, while knockdown drastically suppressed vivo growth A549 H1299 NSCLC cells. Knockdown inhibition decreased expression focal adhesion kinase (FAK) protein...
EGFR-mutated lung adenocarcinoma patients who received tyrosine kinase inhibitors (TKIs) may initially respond to therapy, but over time, resistance eventually occurs. In a small population (5-10%), these can have histological transformation SCLC. Nine with transformed SCLC were evaluated at City of Hope. Patient clinical and pathology data, including multiple next-generation sequencing (NGS) results, therapies, histology, outcomes, collected across time points. Descriptive statistics...
Abstract Background Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression associated with aggressive growth, metastasis, therapy resistance various human cancers including lung cancer. However, gene amplification seldom occurs, the mechanism underlying upregulation remains largely unknown. Methods A luciferase reporter driven by promoter region of was selectively constructed to screen against customized...
Introduction Immune checkpoint inhibitors (ICIs) produce a broad spectrum of immune-related adverse events (irAEs) affecting various organ systems. While ICIs are established as therapeutic option in non-small cell lung cancer (NSCLC) treatment, most patients receiving ICI relapse. Additionally, the role on survival prior targeted tyrosine kinase inhibitor (TKI) therapy has not been well-defined. Objective To investigate impact irAEs, relative time occurrence, and TKI to predict clinical...
Integrins are transmembrane adhesion receptors that provide the physical link between actin cytoskeleton and extracellular matrix. It has been well established integrins play a major role in various cancer stages, such as tumor growth, progression, invasion metastasis. In breast cancer, integrin alphavbeta3 associated with high malignant potential cells, signaling onset of widespread Many preclinical studies based on cell lines, which may not represent behavior phenotype primary origin, due...
Background: The molecular and clinical features of KRAS-mutated lung cancer patients treated with immunotherapy have yet to be characterized, which could guide the development therapeutics targeting KRAS potential immuno-oncology treatment combinations. Research Question: Do different subtypes comutations responses overall survival (OS) checkpoint inhibitors? Study Design Methods: 87 NSCLC at City Hope who received immune inhibitors were identified analyzed retrospectively. Tumor genomic...
Abstract Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR cells delivered weekly into lateral cerebral ventricles, identifying clonal expansion endogenous CAR-negative CD8 + in cerebrospinal fluid (CSF) over time. Additionally, five evaluable disease response,...
We present a case report of 54-year-old male with metastatic testicular sex cord tumor harboring
Intracranial tumors with heterogeneous histopathology are a well-described pathologic entity. Pathologically, distinct in direct contact one another, also known as collision exceptionally rare, and between meningioma subtypes has not been previously described the literature.A 79-year-old female history of breast carcinoma presenting visual motor deficits imaging/intraoperative findings consistent separate, lesions. Histopathologic provided evidence for World Health Organization Grade III...
Intramedullary nail fixation is the treatment of choice for impending and pathologic fractures secondary to metastatic cancer; however, this procedure has been shown cause systemic embolization intramedullary contents. This article reports use reamer–irrigator–aspirator (RIA) (Synthes, Paoli, Pennsylvania) instead a standard femoral reamer decrease tumor intravasation during or fractures. Twenty-one consecutive patients indicated malignant lesions were treated with placement. The RIA was...
Myxopapillary ependymoma (MPE) is a slow-growing tumor occurring almost exclusively in the region of conus medullaris, cauda equina, and filum terminale. On microscopic examination, some these tumors show solid sheets cells with an epithelioid morphology mimicking metastatic carcinoma. Several immunohistochemical studies addressed this issue discordant results. We report findings 9 additional cases MPE. From 2004 to 2011, total MPE were recorded our surgical pathology files. The histologic...
Metastasis continues to be the primary cause of all cancer-related deaths despite recent advancements in cancer treatments. To evaluate role mutations overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major types who had available molecular testing results a FoundationOne CDx® panel. The most prevalent genes somatic were TP53, KRAS, APC, LRP1B. In this analysis, these mutation frequencies higher than publicly datasets. We identified that mutually...
Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs is considered as a novel anticancer therapeutic strategy. Overexpression of ubiquitin specific protease 7 22 (USP7 USP22) are associated with malignancy, therapy resistance, poor prognosis many cancers. Although both involved the regulation similar genes signaling pathways, such histone H2B monoubiquitination (H2Bub1), c-Myc, FOXP3, p53, interdependence USP22 USP7 expression has never been described. In...
Combined tumors showing histologic features of both ependymoma and subependymoma have been described. In this report we present a case combined tanycytic with foci (WHO grade II), occurring in 40 year-old male, which arose the wall lateral ventricle. The component showed elongated fibrillary cells fascicular pattern growth, while clustered cell bodies surrounded by stroma microcystic appearance.We consider to be an unusual example ependymoma; best our knowledge has not associated subependymoma.
We present two natalizumab-treated multiple sclerosis patients who developed glioblastoma multiforme (GBM) with variable outcomes. One patient had an isocitrate dehydrogenase (IDH)-wildtype GBM aggressive behavior, declined treatment and died 13 weeks after symptoms onset. The other underwent resection of IDH-mutant secondary that arose from a previously diagnosed grade II astrocytoma. He is still alive 5 years the diagnosis GBM. JC virus was not detected in either case. Whether natalizumab...