A5083913696- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis and biological activity
- Organometallic Compounds Synthesis and Characterization
- Organometallic Complex Synthesis and Catalysis
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Protein Interaction Studies and Fluorescence Analysis
- Porphyrin and Phthalocyanine Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Nanomaterials for catalytic reactions
- Phytochemical compounds biological activities
- Antimicrobial agents and applications
- Piperaceae Chemical and Biological Studies
- Cancer therapeutics and mechanisms
Universidade de São Paulo
2021-2025
Instituto Butantan
2024
Universidade Federal de São Carlos
2015-2024
Instituto de Psicologia Comportamental de São Carlos
2023
Universidade Federal de Goiás
2020-2022
Fundação de Apoio a Pesquisa do Estado de Goiás
2020
The Netherlands Cancer Institute
2018
Universidade Estadual de Goiás
2016
Clinics Hospital of Ribeirão Preto
2006
In this study, half-sandwich Ru(II) complexes containing acylthiourea ligands of the general type [Ru(η6-p-cymene)(PPh3)(S)Cl]PF6 (1m–6m) and [Ru(η6-p-cymene)(PPh3)(S–O)]PF6 (1b–6b) where S/S–O = N',N'-disubstituted were synthesized characterized (via elemental analyses, IR spectroscopy, 1H NMR 13C{1H} X-ray diffractometry), their cytotoxic activity was evaluated. The different coordination modes ligands, monodentately via S bidentately S,O (1b–6b), to ruthenium modulated from synthetic...
A 3D coordination polymer of Tb( iii ) formula [Tb(bttb) 0.5 (2,5-pzdc) ] n , where two polycarboxylate ligands act as linkers, exhibits a maximum relative sensitivity 0.76% K −1 at 295 K.
Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense interest due to its anticancer characteristics target the oxidative stress. In present paper, two novel piplartine-containing ruthenium complexes [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) were synthesized investigated for their cellular molecular responses on cancer cell lines. We found both are more potent than metal-free piplartine in panel of lines monolayer...
The triple-negative breast cancer subtype (TNBC) is highly aggressive and metastatic corresponds to 15–20% of diagnosed cases. TNBC treatment hampered, because these cells usually do not respond hormonal therapy, they develop resistance chemotherapeutic drugs. On the other hand, severe side effects cisplatin represent an obstacle for its clinical use. Ruthenium (Ru)-based complexes have emerged as promising antitumor antimetastatic substitutes cisplatin. In this study, we demonstrated a...
Melanoma is the most aggressive and lethal skin cancer that affects thousands of people worldwide. Ruthenium complexes have shown promising results as chemotherapeutics, offering several advantages over platinum drugs, such potent efficacy, low toxicity, less drug resistance. Additionally, anthraquinone derivatives broad therapeutic applications, including melanoma. Thus, two new ruthenium with 1-hydroxy-9,10-anthraquinone were obtained: trans-[Ru(HQ)(PPh3)2(bipy)]PF6 (1)...
Upon exploration of the chemistry combination ruthenium/arene with anthraquinone alizarin (L), three new complexes general formulas [Ru(L)Cl(η6-p-cymene)] (C1), [Ru(L)(η6-p-cymene)(PPh3)]PF6 (C2), and [Ru(L)(η6-p-cymene)(PEt3)]PF6 (C3) were synthesized characterized using spectroscopic techniques (mass, IR, 1D 2D NMR), molar conductivity, elemental analysis, X-ray diffraction. Complex C1 exhibited fluorescence, such as free alizarin, while in C2 C3, emission was probably quenched by...
The well-known anti-inflammatory drug diclofenac can form new ruthenium compounds with promising anti-tumor properties.
We have synthesized and characterized three new ruthenium(II) diphosphine complexes containing an acylthiourea ligand, with the general formula [Ru(DPEPhos)(O,S)(bipy)]PF6, where DPEPhos = bis(2-(diphenylphosphino)phenyl)ether, bipy 2,2'-bipyridine, O,S N,N-dimethyl-N'-(benzoyl)thiourea (1), N,N-dimethyl-N'-(furoyl)thiourea (2), N,N-dimethyl-N'-(thiophenyl)thiourea (3), by several physicochemical techniques. evaluated ruthenium for their cytotoxicity against two human cancer cell lines, A549...
Novel gold( i )(NHC) containing thiopyrimidines and thiazolidines with promising antiviral antiparasitic activity.
Luminescent trivalent lanthanide (Ln3+) complexes are compounds of technological interest due to their unique photophysical properties, particularly anionic tetrakis complexes, given higher stability and emission quantum yields. However, structural studies on the cation–anion interaction in these relation such luminescence still lacking. Herein, interactions two luminescent tetrakis(2-thenoyltrifluoroacetonato)europate(III) with alkylimidazolium cations, specifically...
Implementing additional optical (luminescent) properties into the well-known class of single-molecule magnets (SMMs) is considered as a promising route toward obtaining next generation optomagnetic materials for quantum information storage and computing. Herein, we report joint magneto-structural study two novel series lanthanide(iii) complexes general formula Bu4N[LnIII(HL)4(dmso)]·nH2O where H2L = N-(4-Xphenyl)oxamic acid with X Cl n 2 [Ln Eu (1_Cl), Gd (2_Cl), Dy (3_Cl), Tb (4_Cl)] F 3...
Ru(<sc>ii</sc>) complexes with gallic acid and derivatives interact biomolecules show high SI among non-tumor/tumor breast cells. The complex causes damage to the cell cytoskeleton inhibiting adhesion, invasion, migration of tumor
TbIII and EuIII systems have been investigated as ratiometric luminescent temperature probes in coordination polymers due to → energy transfer (ET). To help understand how ion-ion separation, chain conformation well excitation channel impact their thermometric properties, herein, [Eu(tfaa)3(μ-L)Tb(tfaa)3]n one-dimensional (1D) (tfaa- = trifluoroacetylacetonate, L [(diphenylphosphoryl)R](diphenyl)phosphine oxide, R ethyl - dppeo or butyl dppbo) were synthesized. The short μ-dppeo bridge...
Ruthenium complexes with piplartine, [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) (dppf = 1,1-bis(diphenylphosphino) ferrocene; dppb 1,4-bis(diphenylphosphino)butane bipy 2,2'-bipyridine), were recently synthesized displayed more potent cytotoxicity than piplartine in different cancer cells, regulated RNA transcripts of several apoptosis-related genes, induced reactive oxygen species (ROS)-mediated apoptosis human colon carcinoma HCT116 cells. The present...