A5089701035- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Ferrocene Chemistry and Applications
- Organometallic Compounds Synthesis and Characterization
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Organometallic Complex Synthesis and Catalysis
- DNA and Nucleic Acid Chemistry
- Lanthanide and Transition Metal Complexes
- Immune cells in cancer
- Metal-Catalyzed Oxygenation Mechanisms
- Biochemical and biochemical processes
- Porphyrin and Phthalocyanine Chemistry
- Plant biochemistry and biosynthesis
- Chemical Reaction Mechanisms
- Free Radicals and Antioxidants
- Botanical Research and Applications
- Asymmetric Hydrogenation and Catalysis
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Cancer therapeutics and mechanisms
Universidade Federal de São Carlos
2019-2024
Universidade de São Paulo
2023
Universidade Estadual de Santa Cruz
2016-2021
Institute of Catalysis and Petrochemistry
2019
The search for new metal-based anticancer drug candidates is a fundamental task in medicinal inorganic chemistry. In this work, we assessed the potential of two Ru(II)-phosphine-mercapto complexes as agents. complexes, with formula [Ru(bipy)(dppen)(Lx)]PF
Three Ruthenium(II)-phosphine based complexes with the general formula [Ru(N–S)(dppm)2]PF6 (Ru1–Ru3) were prepared and studied as anticancer agents [N–S are 2-mercapto-2-thiazoline (Hmtz), mercapto-1-methylimidazole (Hmmi) 4,6-diamino-2-mercapto-pyrimidine (Hdmp) dppm is the...
The objective of this study was to optimize the enzymatic pretreatment process extracting menthol, a major component essential oil stored in trichomes fresh leaves Mentha arvensis, by action crude extract previously produced Aspergillus niger fungus cultivated cactus pear. Under experimental conditions 42 °C, 141 min and 58 mL enzyme 442 water, there an increase 186.63% hydrodistillation yield, which represents acceptable positive deviation 12.54% compared predicted value model obtained...
Six complexes with the general formula [Cu(acylthioureato)(PPh3)2] were synthesized and characterized using spectroscopic techniques (IR, UV/visible, 1D 2D NMR), mass spectrometry, elemental analysis, X-ray diffraction. Interpretation of in vitro cytotoxicity data Cu(I) took into account their stability cell culture medium. DFT calculations showed that NMR properties, such as shielding carbon atoms, are affected by relativistic effects, supported ZORA Hamiltonian theoretical calculations....
Four new Cu/PPh3/naphtoquinone complexes were synthesized, characterized (IR, UV/visible, 1D/2D NMR, mass spectrometry, elemental analysis, and X-ray diffraction), evaluated as anticancer agents. We also investigated the reactive oxygen species (ROS) generation capacity of complex 4, considering well-established photochemical property naphthoquinones. Therefore, employing electron paramagnetic resonance (EPR) “spin trap”, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) technique, we identified...
Lawsone itself exhibits interesting biological activities, and its complexation with a metal center can improve the potency. In this context cytotoxic Ru-complex, [Ru(law)(dppb)(bipy)] (law = lawsone, dppb 1,4-bis(diphenylphosphino)butane bipy 2,2'-bipyridine), named as CBLAU, was prepared reported. work, NMR binding-target studies were performed to bring light most accessible interaction sites of Ru-complex toward Calf-Thymus DNA (CT-DNA, used model), in similar approach for other metallic...
Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− methylacetoacetate; L2− ethyl 4-chloroacetoacetate) have been prepared investigated as prototypes of bioreductive prodrugs. The presence β-ketoester py2en ligands in 1 2, well the perchlorate counterions, was supported by IR spectroscopy CHN elemental analysis. composition molecular structure both...
Departamento de Ciencias Exatas e Tecnologicas Universidade Estadual Santa Cruz - UESC, Rodovia Jorge Amado Km 16
Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1 methylacetoacetate; L2 ethyl 4-chloroacetoacetate) have been prepared investigated as prototypes of bioreductive prodrugs. The presence β-ketoester py2en ligands in 1 2, well the perchlorate counterions, was supported by IR spectroscopy CHN elemental analysis. composition molecular structure both...