Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation cytokine production. The present study was undertaken evaluate whether 1 has antinociceptive properties in models inflammatory pain and investigate its possible mechanisms action. Pretreatment (12.5–100 mg/kg, ip) produced dose-related inhibition acetic acid-induced writhing mice. Furthermore, treatment (50 100 mg/kg) inhibited both the early late phases formalin test. In...

7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models pain. However, biochemical events involved antinociception mediated by 1 are currently not well understood. In present study, mechanisms which exerts its pharmacological actions were investigated. Acute pretreatment mice with produced a long-lasting effect against complete Freund's adjuvant (CFA)-induced hyperalgesia. The subchronic...

Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties investigate possible mechanisms involved with its effects. RO first suggested by formalin test mice, an inflammatory pain model, because intraperitoneal (i.p.) administration (50 100mg/kg) inhibited only late phase test. To further RO, complete Freund's adjuvant...

The currently used treatments for leishmaniasis, a neglected parasitic disease, are associated with several side effects, high cost and resistance of the Leishmania parasites. Here we evaluated in vitro vivo antileishmanial activity five antimalarial drugs against amazonensis. Mefloquine was effective promastigotes axenic cultures showed an IC50 (concentration giving half-maximal inhibition) value 8.4±0.7 µM. In addition, mefloquine, chloroquine hydroxychloroquine were active intracellular...

Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified 1970s becoming global back bone to fight against malaria. Our research group previously developed an economic ecological friendly process obtain this compound. In pursuit also exploit residue generated throughout we further evaluated pharmacological potential of that extract. The alcoholic crude extract after artemisinin precipitation...

Artemisia annua L., known for antimalarial activity, has demonstrated evidence of anti-inflammatory potential. Previously our research group reported the and antinociceptive effect a sesquiterpene lactone-enriched fraction (Lac-FR) obtained from plant, containing artemisinin deoxyartemisinin. Both isolated compounds Lac-FR evaluated on experimental animal models, in formalin test showed that deoxyartemisinin reduced both neurogenic pain (56.55 %) inflammatory (45.43 %). These findings were...

Um estudo florístico e taxonômico da família Vittariaceae no Sudeste do Brasil é apresentado. Sete dos dez gêneros que compreendem esta são americanos. Cinco nove espécies ocorrem na região estudada: Anetium Splitg. Hecistopteris J. Sm., com uma espécie cada; Polytaenium Desv. três espécies; Radiovittaria (Benedict) E.H. Crane Vittaria duas cada. Foram elaboradas chaves para determinação de espécies. As tratadas foram descritas ilustradas, sendo incluídos comentários taxonômicos ecológicos.

Purpose: The prevalence of head lice in poor rural communities and urban slums is estimated to be between 28% 43% Brazil, respectively. Children are among the most affected, often clusters within schools. We launched a program intending tackle social stigma associated with using scientific information local traditional remedy as way lower low-resource community. Methods: A involving entire school community teachers addressed how treat avoid new infestations. An affordable solution widely...

O trabalho apresenta espécies de samambaias e licófitas um fragmento Mata Atlântica, inserido na região semi-árido, localizado Serra da Jibóia, Município Santa Teresinha, Bahia, Brasil a análise das relações florísticas com outras formações vegetais do país, contribuindo para ampliar as informações sobre flora vascular estado, bem como bioma Atlântica. São apresentadas 97 espécies, em 51 gêneros 22 famílias. As famílias mais representativas foram Dryopteridaceae (17 spp.), Polypodiaceae (16...

Many scientific reports have described the biological activity of species from Boehmeria genera (Urticaceae). Nevertheless, no studies on anti-inflammatory effect products this plant been reported. Therefore, scope study was to evaluate caudata Sw.(BC) crude ethanol extract croton oil-induced mouse ear oedema model. Three experiments were performed, using different treatments: oral gavage, intraperitoneal injection (i.p.) and per topical application. In each experiment, mice (19 – 23 g, 2...

A família Vittariaceae está representada no Estado de Mato Grosso, Brasil, pelos gêneros Anetium, Antrophyum, Hecistopteris (com uma espécie cada) e Vittaria três espécies). Chaves identificação para espécies, breves descrições, ilustrações, bem como comentários sobre distribuição habitats são apresentados.

A Chapada Diamantina é a porção da Cadeia do Espinhaço localizada na posição central Estado Bahia. Está inserida no bioma Caatinga e compreende 58 municípios. O presente trabalho registra o levantamento florístico, as descrições ilustrações de 11 espécies Schizaeales encontradas Diamantina, além chaves identificação para famílias espécies. As foram: Anemia dentata Gardner ex Field & Gardner, A. ferruginea Humb. Bonpl. Kunth, hirsuta (L.) Sw., oblongifolia (Cav.) phyllitidis rutifolia...

This work presented the inventory of ferns and lycophytes Jaú, São Paulo state. Sixty-eight species one lycophyte were recorded, distributed in 16 families 32 genera. The richest Pteridaceae Thelypteridaceae with 15 each, Polypodiaceae (7spp.), Blechnaceae Dryopteridaceae (5 spp. each). most common guild life form was terrestrial herbs 57 species, followed by epiphytes (6 spp.), arborescent, aquatic lithophytes (2 each) hemiepiphytes scandents each. analysis geographical distribution showed...

Abstract The tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search new drugs, plants have shown to be an effective source potent anti-inflammatory and anticancer agents. This study aimed evaluate the antitumoral inflammatory activities Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from B. ethanolic extract had a straight relationship activity. Moreover,...

Thelypteris villosa (Link) C. F. Reed, espécie rara, até recentemente tratada como endêmica da Floresta Atlântica do Estado Rio de Janeiro, é referida pela primeira vez para a região Nordeste Brasil, Bahia, contribuindo ampliar as informações respeito espécie.

In the context of cancer-inflammation relationship and use natural products as potential antitumor anti-inflammatory agents, alkaloid-enriched fraction Boehmeriacaudata (BcAEF) aerial parts was evaluated. vitro antiproliferative studies with human tumor cell lines showed high activity at low concentrations. Further investigation on NCI-H460 cells an irreversible effect proliferation, cycle arrest G2/M phase programmed death induction. Molecular docking four alkaloids identified in BcAEF...

Apresenta-se um levantamento das samambaias e licófitas que ocorrem no remanescente de Floresta Atlântica, localizado 19° Batalhão Caçadores (19º BC), na Cidade Salvador, Bahia, Brasil, contribuindo para o conhecimento da flora vascular região Nordeste do Brasil. A área possui ca. 240 ha vem sendo conservada pelo Exército Brasileiro. Foram encontradas 30 espécies, distribuídas em 19 gêneros 11 famílias. família Pteridaceae foi a mais representativa (9 spp.), seguida Thelypteridaceae (6 spp.)...

RESUMO O objetivo do presente estudo foi inventariar as samambaias e licófitas de um fragmento floresta paludosa, no Município Dois Córregos, São Paulo, Brasil, além fornecer dados sobre guildas formas vida, distribuição geográfica, chave para identificação comentários dos táxons. Foram encontrados 54 táxons, incluindo 51 espécies, uma variedade, subespécie suposto híbrido. Os gêneros mais representativos foram Amauropelta, Meniscium Pleopeltis. As espécies herbáceas terrícolas neotropicais...

This study describes the Ferns and Lycophytes species present in Mata de Santa Genebra reserve, biggest forest fragment municipality of Campinas.A total 34 belonging to 22 genera were recorded area.Thelypteridaceae was most diverse family (8 spp.), followed by Polypodiaceae Pteridaceae (7 Dryopteridaceae (3 Blechnaceae, Cyatheaceae Schizaeaceae (2spp.), Dennstaedtiaceae, Lindsaeaceae Vittariaceae (1 sp.).