A5074108720- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Ferrocene Chemistry and Applications
- Synthesis and biological activity
- Inorganic and Organometallic Chemistry
- Drug Transport and Resistance Mechanisms
- Marine Sponges and Natural Products
- Organometallic Compounds Synthesis and Characterization
- Crystal structures of chemical compounds
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Magnetism in coordination complexes
- HIV/AIDS drug development and treatment
- Free Radicals and Antioxidants
- Click Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Phenothiazines and Benzothiazines Synthesis and Activities
- Kruppel-like factors research
- HER2/EGFR in Cancer Research
- Enzyme function and inhibition
- Various Chemistry Research Topics
- Metal-Catalyzed Oxygenation Mechanisms
- Asymmetric Hydrogenation and Catalysis
Comprehensive Cancer Center Vienna
2024-2025
Medical University of Vienna
2024-2025
University of Vienna
2020-2025
Universidade Estadual de Campinas (UNICAMP)
2012-2022
COTI-2 is a novel anticancer thiosemicarbazone in phase I clinical trial. However, the effects of metal complexation (a main characteristic thiosemicarbazones) and acquired resistance mechanisms are widely unknown. Therefore, this study, copper iron complexes were synthesized evaluated for their activity impact on drug comparison to metal-free thiosemicarbazones. Investigations using Triapine-resistant SW480/Tria newly established COTI-2-resistant SW480/Coti cells revealed distinct...
Platinum chemotherapy is part of every second anticancer treatment regimen. However, its application limited by severe side effects and drug resistance. The combination platinum-based chemotherapeutics with EGFR inhibitors has shown remarkable synergism in clinical treatment. To enhance the tolerability this combination, we designed a novel multi-action oxaliplatin-based platinum(iv) complex an EGFR-inhibiting moiety (KP2749). KP2749 releases two independent cytotoxic agents upon reduction:...
Abstract New copper(II) complexes, derived from the isomers 5‐(trifluoromethyl)uracil ( L 1 ) and 6‐(trifluoromethyl)uracil 2 with 2,2′‐bipyridine Bpy ), [Cu(H O)(L Bpy] Bpy], were synthesized, characterized, evaluated for their antibacterial antitumoral properties. Chemical analyses suggest molecular formula CuC 20 H 12 F 6 N O 4 ·H both complexes. Infrared spectroscopic indicate that trifluoromethyluracil coordinate to by oxygen atoms. Structural confirmation of complex was obtained single...
COTI-2 is currently being evaluated in a phase I clinical trial for the treatment of gynecological and other solid cancers. As thiosemicarbazone, this compound contains an N,N,S-chelating moiety is, therefore, expected to bind endogenous metal ions. However, besides zinc, interaction properties have not been investigated detail so far. This unexpected, as we recently shown that forms stable ternary complexes with copper glutathione, which renders drug substrate resistance efflux transporter...
We describe herein an efficient and diastereoselective substrate-directable Heck–Matsuda reaction with nonactivated five-membered olefins. The carbamate acts as the main directing group in arylation process allowing synthesis of several functionalized aryl cyclopentenes good to excellent diastereoselectivities (>85:15) isolated yields ranging from 41 90%. No double bond isomerizations were observed these Heck reactions, newly created benzylic centers preserved all cases examined. substrate...
An interesting practical experiment about the preparation of dye-sensitized solar cells (DSSC) using natural dyes were carried out by undergraduate students in chemistry course at UNICAMP .Natural extracted from blueberries (Vaccinium myrtillus L.), jabuticabas (Myrciaria cauliflora), raw and cooked beets (Beta vulgaris annattos (Bixa orellana which used to sensitize TiO 2 films that composed photoanode DSSC.A polymer electrolyte containing an iodide/triiodide redox couple was lieu use...
Metal complexes with antitumor activities have been studied as an alternative to overcome tumor resistance current pharmaceuticals. Recently, we described the synthesis of a silver(I) complex 5-fluorouracil (Ag-5fu) effective activity in vitro against human multi-resistant ovarian cells (NCI/ADR-RES) when compared (5fu) and cisplatin. Therefore, for better understanding effect Ag-5fu its precursors 5fu silver(I), compounds were evaluated by colony formation capacity flow cytometry assays...
In the context of cancer-inflammation relationship and use natural products as potential antitumor anti-inflammatory agents, alkaloid-enriched fraction Boehmeriacaudata (BcAEF) aerial parts was evaluated. vitro antiproliferative studies with human tumor cell lines showed high activity at low concentrations. Further investigation on NCI-H460 cells an irreversible effect proliferation, cycle arrest G2/M phase programmed death induction. Molecular docking four alkaloids identified in BcAEF...
Abstract Pd‐catalyzed treatment of the cyclopentene (I) with various arenediazonium borates results in efficient and stereoselective formation products type (III).
Um complexo inédito de Cu(II) com os ligantes fenantrolina e sulfametizol foi obtido caracterizado por um conjunto análises químicas espectroscópicas.A estrutura do resolvida difratometria raios X monocristal, sendo que o se coordena ao cobre pelo átomo nitrogênio anel heterocíclico.Ensaios concentração inibitória mínima (CIM) frente bactérias Gram-positivas Gram