A5038940453- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuropeptides and Animal Physiology
- Oral microbiology and periodontitis research
- Bone and Joint Diseases
- Musculoskeletal Disorders and Rehabilitation
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Parasites and Host Interactions
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Pharmacological Effects of Natural Compounds
- Bone health and treatments
- Research on Leishmaniasis Studies
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Adolescent and Pediatric Healthcare
- Eicosanoids and Hypertension Pharmacology
Universidade Federal do Ceará
2016-2025
Universidade Estadual Paulista (Unesp)
2012-2024
Governador Celso Ramos Hospital
2023
Université de Sherbrooke
2001-2023
Fundação Faculdade de Medicina
2019-2022
Universidade Estadual do Ceará
2021
Hospital Geral de Fortaleza
2012-2019
Sociedade Brasileira de Ortopedia e Traumatologia
2017
Fundação CECIERJ
2015
Hospital Universitário Walter Cantídio
2010-2015
Prostaglandins are implicated in periodontal bone destruction. We investigated the effect of a non-selective cyclooxygenase (COX) inhibitor (indomethacin-IND) or type 2 COX (meloxicam-MLX) an experimental disease (EPD) model.Wistar rats were subjected to placement nylon thread ligature around maxillary molars and sacrificed after 7 days. Alveolar loss (ABL) was measured one quadrant as distance between cemento-enamel junction alveolar bone. The other processed for histopathologic analysis....
The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5 ng/animal), IL-10 (0.4–10 or IL-13 (0.4–2.5 ng/animal) inhibited the writhing response induced by i.p. administration acetic acid (53–89%) zymosan (63–74%) mice, knee joint incapacitation i.a. injection (49–66%) rats. Neither cytokines affected elicited mice using hot-plate test. This analgesic effect IL-4,...
Periodontitis is the most frequent cause of tooth loss in adults. Nitric oxide (NO) has been linked to bone resorption mechanisms during inflammation processes. The aim this study was investigate effect NOS (NO synthase) inhibitors alveolar an experimental periodontitis disease (EPD) model.Wistar rats were subjected a ligature placement around second upper left molars and sacrificed at 11 days. Alveolar evaluated by sum distances between cusp tips along axis each molar root, subtracting from...
Abstract Leukotriene B4 (LTB4) mediates different inflammatory events such as neutrophil migration and pain. The present study addressed the mechanisms of LTB4-mediated joint inflammation-induced hypernociception. It was observed that zymosan-induced articular hypernociception were reduced dose-dependently by pretreatment with MK886 (1–9 mg/kg; LT synthesis inhibitor) well in 5-lypoxygenase-deficient mice (5LO−/−) or selective antagonist LTB4 receptor (CP105696; 3 mg/kg). Histological...
Chlorpromazine (CPZ), a phenothiazine derivative, possesses anti‐inflammatory properties, inhibition of tumor neurosis factor‐α(TNF‐α) synthesis and bone resorption. TNF‐α promotes inflammatory changes resorption in periodontitis. We have studied the effect CPZ experimental Wistar rats were subjected to ligature placement around cervix right second upper molars. Alveolar loss was evaluated by sum distances between cusp tip alveolar along axis each molar root, which subtracted from...
Bisphosphonates are potent inhibitors of bone resorption and were shown to inhibit in experimental periodontitis by unknown mechanisms. We studied the effect aminobisphosphonate sodium alendronate (SA) periodontitis. Wistar rats subjected ligature placement around second upper left molars.Animals treated with SA 0.01 0.25 mg/kg subcutaneously (sc), either 1 hour before (prophylactic) or starting 5 days after (therapeutic) induction daily until sacrificed (11 days). Controls received saline....
A comprehensive description of nasal septal cartilage (NSC) across all age groups is an unmet need. This information could help improve facial reconstruction, particularly in childhood. We describe cellular distribution and metabolic activity the NSC fetus, newborn, 2-year-old infants using postmortem samples. Cell density 9 areas isogenous groups/hpf were counted on hematoxylin-eosin-stained sections. The production glycosaminoglycans, measured Safranin O staining, was used as a surrogate...
The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models. Pentoxifylline (0.5–1.6 mg kg −1 ) given 30 min before the stimulus significantly inhibited writhing response induced by intraperitoneal (i.p.) administration either acetic acid (−90%) or zymosan (−83%), but not that iloprost, mice, as well zymosan‐induced articular hyperalgesia arthritis rats (−50%). also mechanical hypernociception intraplantar injection carrageenin (−81%), bradykinin (−56%)...
We investigated the effect of an extract from a helminth (Ascaris suum) in zymosan-induced arthritis (ZYA) or collagen-induced (CIA). Rats and mice, respectively, received 1 mg 0.1 zymosan intra-articularly (i.a.). Test groups A. suum either per os (p.o.) intraperitoneally (i.p.) 30 min prior to i.a. zymosan. Controls saline. Hypernociception was measured using articular incapacitation test. Cell influx, nitrite, cytokine levels were assessed joint exudates. The synovia distal femoral...
Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing bone resorption in inflammatory diseases. We determined whether subantimicrobial doses doxycycline (DX) (<=10 mg kg-1 day-1), a known MMP inhibitor, could inhibit an experimental periodontitis model. Thirty male Wistar rats (180-200 g) were subjected placement nylon thread ligature around the maxillary molars and sacrificed after 7 days. Alveolar loss (ABL) was measured...
Background: Pentoxifylline (PTX) and thalidomide (TLD) have been shown to inhibit cytokine synthesis, mainly tumor necrosis factor (TNF)‐α, in different inflammatory conditions. We studied the effects of these inhibitors an experimental model periodontitis. Methods: Wistar rats were subjected a ligature placement around second upper right molars. Alveolar bone loss was evaluated by sum distances between cusp tip alveolar along axis each molar root, subtracting from contralateral side....
We investigated the effect of phosphodiesterase-5 inhibitor, tadalafil, on acute hypernociception in rat models arthritis.Rats were treated with either an intra-articular injection zymosan (1 mg) or surgical transection anterior cruciate ligament (as osteoarthritis model). Controls received saline sham operation respectively. Joint pain was evaluated using articular incapacitation test measured over 6 h following between 4 and 7 days after transection. Cell counts, tumour necrosis factor-α...
Objective. To analyze the clinical effect of enthesitis in a large Brazilian cohort patients with spondyloarthritis (SpA). Methods. A common protocol investigation was prospectively applied to 1505 SpA 29 centers Brazil. Clinical and demographic variables disease indexes were investigated. The Maastricht Ankylosing Spondylitis Enthesitis Score used investigate component. spondylitis most frequent group (65.4%). Others psoriatic arthritis (18.4%), undifferentiated (6.7%), reactive (3.3%),...
Abstract Objective Despite some knowledge gaps in scientific evidence, MgCl 2 is largely used for pain relief musculoskeletal diseases. Mg salts were shown to provide analgesia postoperatively orthopedic surgery and low levels linked arthritis development severity. We determined the anti-inflammatory activity of an acute model. Methods Mice received 0.1 mg/25µL Zymosan (Zy) or saline into knees. Joint was evaluated using von Frey test; cell influx, interleukin (IL)-1 level assessed joint...
The contribution of nitric oxide (NO) to articular pain in arthritis induced by zymosan (1 mg, intra articular) rats was assessed measuring incapacitation (AI). Systemic treatment with the non‐selective NO synthase (NOS) inhibitor L ‐NAME (10–100 mg kg −1 i.p.) or selective iNOS inhibitors aminoguanidine (AG; 10–100 1400W (0.5–1 s.c.) inhibited AI injection 30 min later. Local (intra NOS ( AG, 0.1–1 μmol; 1400W, 0.01 (μmol) before also AI. local inhibibitors ‐NAME; 100 i.p. 0.1 μmol joint ;...