A5056689696- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Seaweed-derived Bioactive Compounds
- Reproductive biology and impacts on aquatic species
- Sperm and Testicular Function
- Biochemical Analysis and Sensing Techniques
- Natural Antidiabetic Agents Studies
- Echinoderm biology and ecology
- Aldose Reductase and Taurine
- Therapeutic Uses of Natural Elements
- Environmental Toxicology and Ecotoxicology
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Algal biology and biofuel production
- Polysaccharides and Plant Cell Walls
- Marine and coastal plant biology
- Diabetes and associated disorders
- Vitamin C and Antioxidants Research
- Effects and risks of endocrine disrupting chemicals
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Coenzyme Q10 studies and effects
- Heavy Metal Exposure and Toxicity
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
Universidade Federal de Santa Catarina
2013-2023
Universidade Federal do Rio Grande do Norte
2009-2015
The effect of in vivo treatment with ursolic acid (UA) on glycemia hyperglycemic rats and its mechanism action muscle were studied. UA effects glycemia, glycogen, LDH, calcium insulin levels evaluated after glucose tolerance curve. β-cells through the transmission electron microscopy. was studied muscles uptake with/without specific signaling inhibitors. nuclear GLUT4 expression using thymidine, immunocontent, immunofluorescence RT-PCR. presented a potent antihyperglycemic effect, increased...
The effect of 3β-hidroxihop-22(29)ene (3-BHO) on insulin and glucagon-like peptide 1 (GLP-1) secretion as well the mechanism action compound in pancreatic islet glucose homeostasis was investigated. data from vivo treatment show that 3-BHO significantly reduces hyperglycemia by increasing GLP-1 secretion, accumulating hepatic glycogen hyperglycemic rats. In rat β-cell, stimulates uptake, vesicles translocation to plasma membrane thus through involvement potassium channels (ATP-...
The purpose of the study was to obtain further in vivo data antitumor effects and mechanisms triggered by juglone Q7 combination with ascorbate. done using Ehrlich ascites tumor-bearing mice. Treatments were intraperitoneal every 24 h for 9 days. Control group treated excipient. Previous tests selected doses plus ascorbate (1 100 mg/kg, respectively). Samples ascitic fluid collected evaluate carbonyl proteins, GSH activity antioxidant enzymes such as catalase, superoxide dismutase,...
In this study the in vivo and vitro antidiabetic effects of four acylhydrazone derivatives were investigated rats. The secretagogue action, oral glucose tolerance, insulinogenic index mechanism action these acylhydrazones relation to calcium uptake pancreatic islets studied. Also, insulinomimetic effect on glycemia diabetic rats was verified. Of studied, 1 4 able increase tolerance an acute time-course. A powerful exhibited by glibenclamide with around 3.9 1.3-fold higher than that...
Our objective was to investigate whether the pulp and paper mill industry effluent could affect testis Sertoli cells in a fast exposure period. For this, present study carried out immature rats at 10-day-old. Testis treated vitro with 4% for 1 h presented changes energy metabolism terms of decrease lactate content glucose uptake. Elevation GSH content, as an antioxidant defense mechanism, also detected. hour showed alterations mitochondrial that favor decoupling oxidative phosphorylation...
Abstract The aim of the present study was to investigate mechanism action a sulfonamide derivative on glucose uptake in adipose tissue, as well characterize effects this compound intestinal disaccharidases and advanced glycation end‐products (AGEs) formation. Camphoryl‐benzene (CS) able stimulate isolated adipocytes, soleus muscle. stimulatory effect (10 μM) tissue blocked by diazoxide, wortmannin, U73122, colchicine, N ‐ethylmaleimide. On other hand, CS were not glibenclamide, an inhibitor...
To characterize the role and mechanism of action (2E)-N'-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide (BZD) on incretin secretion, glucose uptake in skeletal muscle α-glucosidase activity intestine, targets for homeostasis. It was assayed tolerance test (GTT) to analyze GLP-1 secretion DPP-4 enzyme vitro. In muscle, carried out by vitro experiments. The intestinal disaccharidases performed after vivo compound improved around 30%, 25%, 20% at 15, 30, 60 min, respectively potentiated...
New compounds with promising antidiabetic activity were synthesized. For the first time, a portion of glibenclamide molecule was bound to part core structure thiazolidinedione evaluate insulin secretagogue activity. Following studies in our laboratory, 4‐{2‐[2‐(3,4‐dichlorophenyl)‐4‐oxo‐1,3‐thiazolidin‐3‐yl]ethyl}benzene‐1‐sulfonamide (DTEBS) selected glycemia using glucose tolerance test and by E.L.I.S.A. The mechanism action this compound studied 45 Ca 2+ influx whole‐cell patch‐clamp rat...
In this study the in vivo and vitro antidiabetic effects of four acylhydrazone derivatives were investigated rats. The secretagogue action, oral glucose tolerance, insulinogenic index mechanism action these acylhydrazones relation to calcium uptake pancreatic islets studied. Also, insulinomimetic effect on glycemia diabetic rats was verified. Of studied, 1 4 able increase tolerance an acute timecourse. A powerful exhibited by glibenclamide with around 3.9 1.3-fold higher than that...
The objective of this study was to investigate the effect and mechanism action fernenediol as an insulin secretagogue. Wistar rats were treated with 0.1, 1, 10 mg/kg before inducing hyperglycemia by oral glucose. glycaemia, insulin, LDH, calcium, hepatic glycogen analyzed. Considering intestine pancreas targets for triterpene action, duodenum used verify influence on intestinal glycosidases. Additionally, pancreatic islets studies 14C-deoxyglucose uptake influx 45Ca2+ in hyperglycemic media...