A5029221843- Natural product bioactivities and synthesis
- Venomous Animal Envenomation and Studies
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Synthesis and Biological Evaluation
- Marine Sponges and Natural Products
- Phytochemistry Medicinal Plant Applications
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Bioactivity Studies
- Natural Antidiabetic Agents Studies
- Antimicrobial Peptides and Activities
- Phytochemistry and Bioactive Compounds
- Biodiesel Production and Applications
- Molecular Sensors and Ion Detection
- Biofuel production and bioconversion
- Research on Leishmaniasis Studies
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Seaweed-derived Bioactive Compounds
- Thermochemical Biomass Conversion Processes
- Antifungal resistance and susceptibility
- Studies on Chitinases and Chitosanases
- Biological Activity of Diterpenoids and Biflavonoids
Universidade Federal do Rio Grande do Norte
2016-2025
Universidade Federal do Rio Grande
2022
Universidade Federal do Ceará
2006-2020
Universidade de Fortaleza
2020
Universidade Federal do Pará
2017
Brazilian Biosciences National Laboratory
2009
The global rise of infectious disease outbreaks and the progression microbial resistance reinforce importance researching new biomolecules. Obtained from hydrolysis chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, greater advantage over chitosan due to their higher solubility lower viscosity. Despite evidence biotechnological potential COSs, effects on trypanosomatids are still scarce. objectives this study were enzymatic...
In the search for new anti-cancer compounds, Brazilian Cerrado plant species have been investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture δ-tocotrienol (1) and its dimer (2). structures both compounds 1 2 were established based on detailed 1D 2D NMR EI-MS analyses. cytotoxicity was tested against four human tumor cell lines in following cultures: MDA-MB-435 (melanoma), HCT-8 (colon), HL-60 (leukemia), SF-295 (glioblastoma), displayed IC50 values ranging from...
This study evaluated the in vitro activity of essential oil extracted from leaves Myracrodruon urundeuva. The was obtained by hydro-distillation and characterized Gas Chromatography coupled to Mass Spectrometry (GC-MS) with Flame Ionization Detector (GC-FID). antibacterial broth microdilution technique MIF determined using growth indicator CTT (2,3,5-triphenyl-tetrazolium) CBM BHI agar. oil's cytotoxicity HeLa, HEK-293, Vero E6 cells MTT, 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl...
O presente trabalho descreve o isolamento de quatro triterpenos (taraxerol, ácido ursólico, 3b,19a,23-triidroxiurs-12-en-28-óico e 2a,3a,19a,23-tetraidroxiurs-12-en-28-óico) um fitoesteróide (espinasterol), bem como a avaliação do potencial antimalárico (cepa NK-65 Plasmodium berghei), larvicida (larvas 4º instar Aedes aegypti), anti-radicalar (2,2-difenil-1-picril-hidrazila, DPPH) anticolinesterásico extratos das folhas, cascas caule Pouteria venosa (Mart.) Baehni. Todos os compostos...
Genipa americana L., Rubiaceae, is a plant native from Brazil popularly known as "jenipapo". Two iridoids, 1-hydroxy-7-(hydroxymethyl)-1,4aH,5H,7aH-cyclopenta[c]pyran-4-carbaldehyde (1), and iridoid 7-(hydroxymethyl)-1-methoxy-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carbaldehyde (2) were isolated identified in the leaf extract of G. americana. Compounds 1 2 for first time americana, has not been yet described literature. These substances analyzed by spectroscopic techniques such infrared, high...
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate anti-ophidian actions triterpenoid saponins found its roots. To assess B. root extract (BFRE) activity against effects Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, anti-edematogenic activities were investigated mice. Phytochemical analysis revealed presence saponins, flavonoids, sugars, with...
Lipidic α-amino acids (LAAs) have been described as non-natural amino with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we obtained a mixture of two cytotoxic LAAs (1a and 1b) zoanthid Protopalythoa variabilis. The anti-proliferative potential 14 synthetic 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, HL-60). Five showed high percentage inhibition, while completely inhibited growth....
Croton cordiifolius Baill. is a shrub known as “quebra-faca” and used to treat inflammation, pain, wounds, gastrointestinal disturbances in the semiarid region northeast of Brazil. In an ethnobotanical survey state Pernambuco, use was cited 33% interviews. Thus, we decided evaluate antinociceptive effects essential oil from C. (CcEO). Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) α -phellandrene (15.43%) major constituents. Antinociceptive activity...