A5071050107- Science and Education Research
- Osteoarthritis Treatment and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Women's cancer prevention and management
- Male Reproductive Health Studies
- Total Knee Arthroplasty Outcomes
- Education during COVID-19 pandemic
- Public Health in Brazil
- Education and Digital Technologies
- Breastfeeding Practices and Influences
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 detection and testing
- Spondyloarthritis Studies and Treatments
- Child Nutrition and Water Access
- Knee injuries and reconstruction techniques
- Health Education and Validation
- Reproductive Health and Contraception
- Proteoglycans and glycosaminoglycans research
- Healthcare Regulation
- Animal Virus Infections Studies
- Antifungal resistance and susceptibility
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Infection Control and Ventilation
Universidade Estadual do Ceará
2024
Fundação Oswaldo Cruz
2021-2024
Universidade Federal do Ceará
2013-2023
Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
2022
Centro Universitário Católica de Quixadá
2018-2021
Abstract Objective Despite some knowledge gaps in scientific evidence, MgCl 2 is largely used for pain relief musculoskeletal diseases. Mg salts were shown to provide analgesia postoperatively orthopedic surgery and low levels linked arthritis development severity. We determined the anti-inflammatory activity of an acute model. Methods Mice received 0.1 mg/25µL Zymosan (Zy) or saline into knees. Joint was evaluated using von Frey test; cell influx, interleukin (IL)-1 level assessed joint...
Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related infections, particularly immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora functions defense mechanisms whereas excessive release TNF inflammation promotes tissue damage. Cytokines released an inflammatory milieu influence the development microorganisms either by promoting their growth or displaying antimicrobial activity....
Abstract We evaluated the longitudinal dynamics of antibody response to SARS-CoV-2 vaccine CoronaVac and effect a booster dose BNT162b2 vaccine. found robust after second that wanes over time. The was recovered by BNT162b2, which boosted anti-spike titers.
Abstract The most widely used vaccines were messenger RNA (mRNA), viral vector, and inactivated virus with two‐dose schedules. In Brazil, the CoronaVac (Sinovac) was first vaccine approved for emergency use, third dose administered, preferably, BNT162b2 vaccine. We evaluated antibody levels after 6 months of booster BNT162B2 in previous recipients whether a subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) infection enhances response. analyze humoral response (spike [S]...
We aimed to determine the characteristics that distinguish glycosaminoglycans (GAGs) from osteoarthritis (OA) and normal cartilage men women. Cartilage samples 30 patients subjected total joint arthroplasty secondary OA or fracture (control) were evaluated, GAG content (μg/mg dry cartilage) after proteolysis was determined by densitometry, using agarose-gel electrophoresis. Relative percentages of carbon (C), nitrogen (N), sulfur (S) in GAGs elemental microanalysis, as well zeta potential....
Abstract Background Injection of Hylan G-F20 (HY) into joints may provoke local flares, which mechanisms involve reaction to protein contaminants. We have previously developed a protein-free saline-soluble galactomannan derived from guar gum (GM) that displays both analgesia and chondroprotection in experimental osteoarthritis (OA). now demonstrate GM promote mild synovitis with cytokine release after intra-articular injection. Methods Mice received 100 μg/25 μL or HY saline the knees. Joint...
Purpose To demonstrate the production of inflammatory mediators by cells located in bone marrow spaces inside rodent menisci. Methods Mice subjected to transection medial collateral and anterior cruciate ligaments meniscotomy (osteoarthritis model) or a sham procedure, as well non-operated (naive) mice rats, had knee joints excised. Tissues were stained with hematoxylin-eosin tartrate-resistant acid phosphatase (TRAP). CD68+ cells, inducible nitric oxide synthase (iNOS), interleukin (IL)-1β,...
Objective: we evaluated the seroprevalence and levels of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies among medical students possible associated factors. Methods: a survey was conducted using data collected in November 2020 February 2022 Fortaleza, Northeast Brazil. A questionnaire administered, blood nasopharyngeal swab samples were collected. The Abbott test used for assessment humoral response to SARS-CoV-2 spike (S) nucleocapsid (N) proteins. total...
Global investment in developing COVID-19 vaccines has been substantial, but vaccine hesitancy emerged due to misinformation. Concerns about adverse events, shortages, dosing confusion, mixing vaccines, and access issues contribute hesitancy. Initially, the WHO recommended homologous vaccination (same for both doses), evolving factors led consideration of heterologous (different vaccines). The study compared reactogenicity antibody response viral protein spike (S) nucleocapsid (N) 205...
Devido ao grande apelo estético com o decorrer dos anos associado há técnicas minimamente invasivas, a odontologia contemporânea aposta em materiais ótimas características estéticas e mecânicas, dessa forma os cirurgiões dentistas buscam apostar no uso do pré-aquecimento das resinas compostas como material cimentante para restaurações indiretas, visto que suas propriedades ópticas mecânicas propõem uma melhor estética adaptação marginal comparação aos cimentos resinosos. O objetivo deste...
In view of the crucial role tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble receptor constructs, are commonly used therapeutics for treatment arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk increased susceptibility to infection with these agents. Spatially distinct from its binding sites, harbors lectin-like domain, which exerts unique functions that...
Abstract Objective To describe parametric changes observed using scanning electron microscopy (SEM) in very early stages posttraumatic osteoarthritis (OA) models mice. Methods Mice (5/group) had their knees subjected to anterior cruciate ligament transection (ACLT), ACLT plus meniscectomy (MNCT) or sham surgery, sacrificed after 3, 7 14 days, the articular cartilage evaluated under optical Osteoarthritis Research Society International (OARSI) parameters as well thickness, roughness, and a...
Purpose To determine alterations of chondroitin sulfate (CS) that reflect cartilage damage in an experimental osteoarthritis (OA) model as well human OA samples.Materials and methods Rats were subjected to anterior cruciate ligament transection (ACLT; OA) or a sham procedure sacrificed 14, 28, 70 days after ACLT for histopathology analysis extracted CS. Cartilage samples from 14 patients undergoing hip shoulder arthroplasty secondary fracture (control) the same protocol. The CS content...
A dor orofacial e, por definicao, uma condicao dolorosa relacionada a tecidos moles e mineralizados da cavidade oral face. E comum no ambiente de atencao primaria saude, na qual disfuncao temporomandibular (DTM) representa suas principais causas. Sendo etiologia multifatorial, DTM pode ser causada fatores psicologicos, traumas parafuncoes, relacionados patologia articular. Com isso, equipe multidisciplinar que, maioria das vezes, sera composta cirurgioes-dentistas, fisioterapeutas...
Objetivo: Analisar evidências científicas sobre os impactos da restrição alimentar no crescimento e desenvolvimento de crianças em fase pré-escolar com história alergia a alimentos. Método: Trata-se uma revisão integrativa literatura que teve como intuito responder seguinte pergunta norteadora “Quais na alimentos?”. A busca base dados foi conduzida nas plataformas Scopus, PubMed, LILACS CINAHL, agosto 2020. Resultados: Dos 9 artigos incluídos, 55,56% constavam todos estavam inglês 33,33%...