A5101654413- Migraine and Headache Studies
- Vestibular and auditory disorders
- Trigeminal Neuralgia and Treatments
- Ophthalmology and Eye Disorders
- Olfactory and Sensory Function Studies
- Pain Management and Placebo Effect
- Botulinum Toxin and Related Neurological Disorders
- Biochemical effects in animals
- Empathy and Medical Education
- Vector-Borne Animal Diseases
- Autoimmune Neurological Disorders and Treatments
- Aquaculture disease management and microbiota
- Photoreceptor and optogenetics research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Myeloid Leukemia Treatments
- Genetic Neurodegenerative Diseases
- Vector-borne infectious diseases
- Cancer Immunotherapy and Biomarkers
- Functional Brain Connectivity Studies
- Plant Disease Resistance and Genetics
- Neurological Complications and Syndromes
- Nicotinic Acetylcholine Receptors Study
- Polyomavirus and related diseases
- Stroke Rehabilitation and Recovery
- Biosimilars and Bioanalytical Methods
Carlo Forlanini Hospital
2021-2024
The University of Texas MD Anderson Cancer Center
2024
University of Campania "Luigi Vanvitelli"
2023-2024
IRCCS San Camillo Hospital
2021
Fondazione G.B. Bietti
2007
University of Liège
2004-2007
Centre hospitalier régional de la Citadelle
2005
Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo 42 patients a double-blind, randomized, placebo-controlled trial. was superior for attack-frequency, headache-days days-with-nausea the third treatment month well tolerated; 50%-responder-rate attack frequency 14.4% 47.6% (number-needed-to-treat: 3). efficacious tolerated.
A deficit of habituation in cortical information processing, including somatosensory evoked potentials (SSEPs), is the most consistent neurophysiological abnormality migraine patients between attacks. To explore further mechanisms underlying this interictal neural dysfunction, we have studied high-frequency oscillations (HFOs) embedded SSEPs because they are thought to reflect spike activity thalamo-cortical cholinergic fibres (early HFOs) and inhibitory GABAergic interneurons (late HFOs)....
To assess the frequency and characteristics of late responders (>12 weeks) to monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP).
Abstract Objective Nearly 60% of migraine patients treated with monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway experience a ≥ 50% reduction in monthly days (MMD) at 12 weeks compared to baseline (responders) . However, approximately half not responding anti-CGRP mAbs ≤ do respond 24 ( late responders) We assessed frequency and characteristics only > ultra-late responders ). Methods In this multicenter n = 16), prospective, observational,...
Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to habituation deficit evoked cortical responses, a reproducible abnormality which has familial character, or central trigeminal sensitization due repeated attacks. We compared nBR healthy volunteers devoid personal family history (HV), without aura patients (MO) and with first degree relatives (HV-F). elicited by stimulating right supraorbital region custom-built...
Long-term (1-year) fremanezumab treatment proved to be effective, safe, and well tolerated in individuals with migraine < 2 medication clusters a randomized controlled trial (RCT). We aimed assess real-world evidence (RWE), long-term effectiveness, tolerability, safety of people high-frequency episodic (HFEM) or chronic (CM) > 3 failures various comorbidities. A 48-week, prospective, multicenter (n = 26), cohort study assessed fremanezumab's safety, tolerability consecutive adults HFEM CM...
Background.—Lack of habituation, as reported in migraine patients between attacks for evoked cortical responses, was also recently found the nociceptive blink reflex (nBR) mediated by brainstem neurons. It is not known if both brain stem and habituation deficits are correlated same patient, which would favor a common underlying mechanism. Objective.—To search intraindividual correlations pattern reversal‐visual potentials that nociception‐specific migraineurs healthy volunteers (HV)....
In order to explore possible interictal brainstem dysfunctions in migraine, we have studied the R2 component of nociceptive specific blink reflex (nBR) after conditioning by supraorbital or index finger stimuli 14 untreated migraine without aura patients (MO) between attacks and 15 healthy volunteers. We determined recovery curve at increasing inter-stimulus intervals 50 600 ms. The nBR was conditioned a paired stimulus and, another session, an ipsilateral electrical shock delivered finger....
In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread accumulation mutations into viruses, limited availability antiviral drugs vaccines, stress urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present promising avenue due their specificity effectiveness against broad spectrum pathogens. study focuses on investigating...
Emerging viruses pose an important global public health challenge, and early action is needed to control their spread. The Bunyaviridae family contains a great number of arboviruses which are potentially pathogenic for humans. For example, phleboviruses affect large range hosts, including humans animals. Some infections usually have asymptomatic course, but others lead severe complications, such as Toscana virus, able cause meningitis encephalitis. Unfortunately, date, no vaccines or...