A5100679087- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Toxoplasma gondii Research Studies
- Characterization and Applications of Magnetic Nanoparticles
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Advanced Glycation End Products research
- Immunotherapy and Immune Responses
- Iron Metabolism and Disorders
- Circular RNAs in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Petroleum Processing and Analysis
- Trace Elements in Health
- Enhanced Oil Recovery Techniques
- Redox biology and oxidative stress
- Microbial Fuel Cells and Bioremediation
- Gas Sensing Nanomaterials and Sensors
- Cardiomyopathy and Myosin Studies
- Barrier Structure and Function Studies
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- Parasitic Infections and Diagnostics
- Immune Response and Inflammation
- Environmental remediation with nanomaterials
Nanfang Hospital
2025
Southern Medical University
2025
Wuhan Third Hospital
2024
Tongren Hospital
2024
Guilin Medical University
2015-2023
Changsha Mining and Metallurgy Research Institute (China)
2022
Sun Yat-sen University
2022
Beijing University of Chemical Technology
2012-2020
Northwestern Polytechnical University
2020
The methods for the delivery of theranostic agents across blood–brain barrier (BBB) are highly required. Superparamagnetic iron oxide nanoparticles (SPIONs) coated with PEG (poly(ethylene glycol)), PEI imine)), and Tween 80 (polysorbate 80) (Tween-SPIONs) were prepared. We demonstrate effective passage tail-vein-injected Tween-SPIONs normal BBB in rats under an external magnetic field (EMF). quantitative analyses show significant accumulation SPIONs cortex near magnet, progressively lower...
We aimed to investigate whether miRNA-1908 is an oncogene in human glioblastoma and find the possible mechanism of miR-1908.We investigated growth potentials miRNA-1908-overexpressing SW-1783 cells vitro vivo. In order identify target molecule miRNA-1908, a luciferase reporter assay was performed, corresponding downstream signaling pathway examined using immunohistochemistry tissues. also expression 34 patients according postoperative risk recurrence.The overexpression significantly promoted...
NAD-dependent protein deacetylase Sirtuin 2 (SIRT2), which regulates several cellular pathways by deacetylating multiple substrates, has been extensively studied in the context of Parkinson's disease (PD). Although studies based on MPTP model PD show that SIRT2 deletion can protect against dopaminergic neuron loss, precise mechanisms SIRT2-mediated neuronal death have largely remained unknown. Here, we knockout effectively ameliorate anomalous behavioral phenotypes transgenic mouse models...
Abstract Aims The accumulation and deposition of β‐amyloid (Aβ) has always been considered a major pathological feature Alzheimer's disease (AD). latest mainstream amyloid cascade hypothesis indicates that all the main changes in AD are attributed to soluble Aβ. However, exploration therapeutic drugs for Aβ toxicity progressed slowly. This study aims investigate protective effects Icaritin on Aβ‐induced Drosophila model its possible mechanism. Methods To identify AD, we constructed an...
High mobility group box 1 (HMGB1) has the capability of activating immune response and taking part in macrophage polarization. Despite this, there is significant scope for exploration into how HMGB1 regulates polarization phenotype influences intestinal epithelial barrier function. Investigating role creation neutrophil extracellular traps (NETs) mechanism its impact on macrophages could provide novel insights intervening inflammation damage. Therefore, research examined relationship between...
Abstract The impact of the surface modification on subcellular distribution nanoparticles in brain remains elusive. prepared by conjugating polyethylene glycol and maleic anhydride‐coated superparamagnetic iron oxide (Mal‐SPIONs) with bovine serum albumin (BSA/Mal‐SPIONs) Arg–Gly–Asp peptide (RGD/Mal‐SPIONs) were injected into rat substantia nigra. Observation transmission electron microscopy (TEM) samples obtained 24 h after perfusion showed that abundant RGD/Mal‐SPIONs accumulated myelin...
Abstract Introduction Iron accumulates in the brain during aging, which catalyzes radical formation, causing neuronal impairment, and is thus considered a pathogenic factor Alzheimer's disease (AD). To scavenge excess iron‐catalyzed radicals thereby protect decrease incidence of AD, we synthesized soluble pro‐iron 5‐YHEDA peptide. However, blood‐brain barrier (BBB) blocks large drug molecules from entering strongly reduces their therapeutic effects. alternative receptor‐ or...
Localizing nanoparticles on or near cell membranes in vivo remains a big challenge. We present membrane targeting complex based chondroitin sulfate (CS)-conjugated superparamagnetic iron oxide (CS-SPIONs). After SPIONs were injected into the substantia nigra of rats, subcellular distributions with and without CS modification have been evaluated by transmission electron microscopy (TEM) analysis. CS-SPIONs exhibited low toxicity endocytosis highly distributed extracellular spaces nearing...
// Haiyan Zheng 1 , Baohua Yang 2 Dedong Xu 4 Wenbo Wang Jie Tan 3 Liyuan Sun Qinghua Li Xuewei Xia 2, Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School Medicine, Yiwu, 322000, Zhejiang, China Guilin Medical University, Guilin, 541001, Guangxi Key Laboratory Brain and Cognitive Neuroscience, Hainan General Haikou, 570311, Correspondence to: Xia, email: xxw7456@163.com Keywords: glioma, immunotherapy, staphylococcal enterotoxin B, interleukin-9, T helper-9...
FITC-SA/PEI-SPIONs attached to the dopaminergic neuronal membrane by means of streptavidin–biotin binding.