A5014754690- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Complement system in diseases
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Rheumatoid Arthritis Research and Therapies
- Protein Tyrosine Phosphatases
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- RNA Interference and Gene Delivery
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Lipoproteins and Cardiovascular Health
- Systemic Sclerosis and Related Diseases
- Liver Diseases and Immunity
- Extracellular vesicles in disease
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Pregnancy and preeclampsia studies
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Peking Union Medical College Hospital
2020-2025
National Clinical Research Center for Digestive Diseases
2021-2025
Ministry of Education of the People's Republic of China
2023-2025
Weatherford College
2024
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
To the Editor: Thrombotic microangiopathy (TMA) is an uncommon hematological involvement in systemic lupus erythematosus (SLE) patients with estimated incidence of 0.5–1%, including but not limited to thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and other secondary conditions. SLE-TMA has a rapid onset poor prognosis, manifesting as microvascular thrombosis, thrombocytopenia, microangiopathic anemia.[1] Based on Chinese SLE Treatment Research Group (CSTAR)...
Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and higher incidence adverse pregnancy outcomes (APOs), can also increase the risk SLE flares. Comprehensive preconception assessment critical for improved in patients SLE. Unfortunately, no global consensus on conditions that should fulfill prior to has yet been formed. This study aimed investigate before optimize outcomes. was retrospective utilizing data from multicenter Chinese cohort. Information...
Our previous work identified several differentially expressed miRNAs (DEmiRNAs) in plasma exosomes from Takayasu's arteritis (TAK) patients. This study aimed to validate these findings and explore the correlation between DEmiRNAs clinical parameters untreated TAK. Plasma were isolated 30 TAK patients 20 healthy controls. qPCR was used quantify miR-34a-5p, miR-143-3p, miR-22-3p, miR-200c-3p, miR-21-5p expression. Correlations miRNA levels, data, inflammation markers, T helper cell frequencies...
Abstract Objective To explore the role and underlying mechanism of Complement Factor H (CFH) in peripheral joint inflammation RA patients. Methods The levels CFH serum synovial fluid were determined by ELISA. pyroptosis monocytes was western blotting flow cytometry. cytokine release tested cell migration invasion ability fibroblast-like synoviocytes (FLS) Wound healing Assay transwell assay, respectively. potential target identified RNA sequencing. Results significantly elevated from...
Atherosclerosis is a chronic, progressive vascular disease. The relationship between CASP1 gene expression and atherosclerosis remains unclear. dataset GSE132651 GSE202625 profiles were downloaded from omnibus. Differentially expressed genes (DEGs) screened. construction analysis of protein–protein interaction network, functional enrichment analysis, set Comparative Toxicogenomics Database performed. Gene heatmap was drawn. TargetScan used to screen miRNAs that regulate central DEG. 47 DEGs...
Pre-eclampsia (PE) is a severe pregnancy complication that more common in patients with systemic lupus erythematosus (SLE). Although the exact causes of these conditions are not fully understood, immune system plays key role. To investigate connection between SLE and PE, we analyzed genes associated may contribute to development PE. We collected 9 microarray data sets from NCBI GEO database used Limma identify differentially expressed (DEGs). In addition, employed weighted gene co-expression...
Systemic lupus erythematosus (SLE) is often related to a lower rate of live birth and higher incidence adverse pregnancy outcomes (APOs), can lead an increased risk SLE flares. Comprehensive preconception assessment crucial, but global consensus regarding the criteria patients should meet before has not been formed yet. This study, conducted retrospectively based on data from Chinese Treatment Research group (CSTAR) registry, multicenter cohort, aimed investigate optimal criteria. Analysis...
Thrombocytopenia (TP) is a hematological manifestation of systemic lupus erythematosus (SLE) and associated with unfavorable prognostic outcomes. This study aimed to develop risk prediction model for new-onset TP in SLE patients. Based on the multicenter prospective Chinese Treatment Research Group (CSTAR) registry, newly diagnosed patients without at registration were enrolled. The least absolute shrinkage selection operator (LASSO) method was used variable selection. final developed using...
The data of 33 patients with adult-onset still's disease (AOSD)-associated macrophage activation syndrome (MAS) were retrospectively collected from January 2013 to December 2020 in Peking Union Medical College Hospital. Hemophagocytic lymphohistiocytosis (HLH)-2004 criteria, syndrome/juvenile idiopathic arthritis (MS-Score) and hemophagocytic diagnostic score (HScore) used diagnose AOSD-associated MAS, respectively. time diagnosis MAS by MS-Score was 19.0 (4.5, 31.0) days [M (Q1,Q3)] earlier...
Abstract Objective To explore the role and underlying mechanism of Complement Factor H (CFH) in peripheral joint inflammation RA patients. Methods The levels CFH serum synovial fluid were determined by ELISA. pyroptosis monocytes was western blotting. cytokine release tested cell migration invasion ability fibroblast-like synoviocyte (FLS) Wound healing Assay transwell assay, respectively. potential target identified RNA sequencing. Results significantly elevated from associated with high...
Abstract Background Scarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case control study aims to survey the prevalence of scarring during course SLE evaluate risk factors for alopecia. Methods Chinese treatment Research group (CSTAR) were recruited. was defined according SLICC/ACR-DI which collected follow-up visit or via self-reported questionnaires. We demographic characteristics, common comorbidities,...
Objective： Although specific anti-phospholipids antibodies (aPLs) have been used in the diagnosis of antiphospholipid syndrome (APS) for years, new biomarkers are required to increase its diagnostic as well risk-predictive power. This study aimed explore value several extra-criteria aPLs a Chinese cohort. Methods： A total 312 patients including 100 diagnosed with primary APS, 51 APS secondary SLE, 71 and 90 health controls were recruited. Serum anticardiolipin (aCL) IgG/IgM/IgA,...