Abstract Immune checkpoint blockade (ICB) is emerging as an efficient strategy for cancer immunotherapy, which highly relies on the controlled loading and release of immune checkpoints inhibitors. Herein, a responsive DNA hydrogel containing polyvalent aptamers dual‐target inhibitors reported to achieve ICB localized immunotherapy. This constructed by two ultralong chains generated via rolling circle amplification (RCA), contained (PD‐1 CTLA‐4 aptamers), loaded with inflammatory‐responsive...

Abstract Messenger RNA (mRNA) transfection is the prerequisite for application of mRNA‐based therapeutics. In hard‐to‐transfect cells, such as macrophages, effective mRNA remains a long‐standing challenge. Herein, smart DNA‐based nanosystem reported containing ribosome biogenesis‐promoting siRNA, realizing efficient in macrophages. Four monomers are copolymerized to form nanoframework (NF), including N ‐isopropylacrylamide (NIPAM) skeleton and acrydite‐DNA initiator trigger cascade assembly...

Background: Bile duct carcinoma (BTC) is an uncommon malignant tumor of the gastrointestinal tract. Management limited after progress first-line treatment. Immune checkpoint inhibitors (ICIs) have been proven popular in solid tumors. Immunotherapy plus chemotherapy has a standard scheme management multiple types cancer. However, their efficacy and safety still need further exploration patients who diagnosed BTC. This research mainly discusses immunotherapy second-line use cholangiocarcinoma....

Pediatric cancer patients in China often present at an advanced stage of disease resulting lower survival and poorer health outcomes. One factor hypothesized to contribute delays pediatric has been the online information-seeking (OHIS) behaviors by caregivers.This study aims examine association between OHIS caregivers for Chinese using a mixed methods approach.This used approach, specifically sequential explanatory design. behavior caregiver was defined as way access information relevant...

This paper studies the encounter patterns and online connections of 76 users in an indoor location sharing interaction social network application, to seek underlying relationship between users' offline behaviors behaviors. We create proximity-based mobile system called Find & Connect that collects records current then enables generate maintain their relationships. obtain quantitative data which presents properties behaviors, perform a user study verify utility applied large meeting events....

This work investigates how to bridge the gap between offline and online behaviors at a conference physical resources in (the objects used for gathering attendees together engaging an activity such as rooms, sessions, papers) can be help facilitate social networking. We build Find Connect, system that integrates activities interactions captured real time with connections environment, provide list of potential people one should connect forming ephemeral network. investigate established...

Objective The purpose of this study was to build nomograms for predicting the survival individual advanced pleural mesothelioma (MPM) patients using Surveillance, Epidemiology, and End Results (SEER) database. Methods 1251 enrolled from SEER database were randomized (in a 7:3 ratio) training cohort an internal validation cohort. Eighty Harbin Medical University Cancer Hospital as external Nomograms constructed variables screened by univariate or multivariate Cox regression analyses evaluated...

Comprehensive Summary Deoxyribonucleic acid (DNA) is a biomacromolecule, as well polymeric material, whose sequences with different manipulative structures enable them to implement series of functions, such reorganization, target, and catalysis. Compared existing traditional materials incapable multifunctional integration, the DNA network form material that can achieve functional integration while maintaining specific properties. Furthermore, precise target enabled by one most essential...

Temperature control has been widely applied in many fields, such as medical product transportation, living tissue storage and blood transfusion. Therefore, it is very important to design a vehicle-mounted temperature system. The priority of the developed system must meet stability accuracy requirement. Based on fuzzy PID control, solution was proposed this paper. includes thermal resistor used front end measure temperature, AD7705 chip Analogy Digital Converter (ADC), TEC component heating...

e17555 Background: PARP inhibitors have been validated for their efficacy as maintenance therapy in newly diagnosed ovarian cancer, but effectiveness neoadjuvant remains uncertain. The aim of this study is to explore the and safety combination pamiparib with chemotherapy bevacizumab patients cancer. Methods: This a single-arm prospective phase II that includes who meet following criteria: ovarian, fallopian tube, or peritoneal cancer FIGO stages III-IV; histologically confirmed high-grade...

e17526 Background: Sintilimab plus Anlotinib has been shown to be effective in advanced cervical cancer the ALTER-C201 Study. Here, we report an updated, post-hoc analysis of overall survival from Study, after 3 years follow-up. Methods: study was a multicenter, single-arm, prospective phase II trial. Patients with PD-L1–positive (Combined Positive Score ≥ 1) R/M CA who progressed at least one prior systemic chemotherapeutic regimen or could not tolerate chemotherapy were eligible for The...

e17525 Background: The Sintilimab plus Anlotinib in patients with advanced cervical cancer trial was a single-arm, phase II study that showed promising activity of the programmed death-1 (PD-1) inhibitor sintilimab vascular endothelial growth factor receptor cancer. We aimed to identify prognostic values inflammation biomarkers and coagulation treated Anlotinib. Methods: conducted post-hoc analysis data from ALTER-C201 (Clinical information: ChiCTR1900023015). predictive value variables...

e17524 Background: In patients with cervical cancer, PIK3CA exhibits the highest mutation rate, predominant oncogenic alteration reported to occur in 40% of cases. Recent studies cancer have indicated that status is prominently associated a diminished overall survival. Nevertheless, our preceding study entitled 'Efficacy and Safety Sintilimab Plus Anlotinib for PD-L1–Positive Recurrent or Metastatic Cervical Cancer: A Multicenter, Single-Arm, Prospective Phase II Trial', prognosis mutant...

<title>Abstract</title> Objective The treatment of biliary tract cancer (BTC) keep still limited, especially after the progress first-line treatment. Immune checkpoint inhibitors (ICIs) have been proved effects in various solid tumors, so as BTC. But their efficacy and safety patients with advanced BTC are need further exploration. Methods clinical information 126 diagnosed between 2014 2024 who received therapy or neoadjuvant but assessing intolerance were retrospectively reviewed. All...

Recently, self-supervised learning (SSL) has been extensively studied. Theoretically, mutual information maximization (MIM) is an optimal criterion for SSL, with a strong theoretical foundation in theory. However, it difficult to directly apply MIM SSL since the data distribution not analytically available applications. In practice, many existing methods can be viewed as approximate implementations of criterion. This work shows that, based on invariance property MI, explicit MI applied under...

This paper proposes an overall maximum torque per ampere (MTPA) control for dc-biased hybrid excitation machine (dc-biased HEM) using MTPA law and virtual signal injection. The mathematical model of the is first analyzed in synchronous rotating reference frame. According to characteristic model, a strategy proposed consists two parts, i.e., employed calculate dominant current references while ensuring rapid dynamic performance. injection method correction scheme deviation caused by parameter...

<sec> <title>BACKGROUND</title> Pediatric cancer patients in China often present at an advanced stage of disease resulting lower survival and poorer health outcomes. One factor hypothesized to contribute delays pediatric has been the online information–seeking (OHIS) behaviors by caregivers. </sec> <title>OBJECTIVE</title> This study aims examine association between OHIS caregivers for Chinese using a mixed methods approach. <title>METHODS</title> used approach, specifically sequential...

Abstract Background: In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve prognosis patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is novel nutritional indicator predict certain malignancies. However, no one has yet pointed to its role in ICI treatment aim this study was investigate significance CONUT cancer receiving treatment. Methods: We retrospectively...