A5067781220- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Antioxidant Activity and Oxidative Stress
- Vitamin D Research Studies
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
First Affiliated Hospital of Xi'an Jiaotong University
2012-2023
Xi'an Jiaotong University
2006-2019
First Hospital of Xi'an
2006
Background:Vitamin C has been demonstrated to kill BRAF mutant colorectal cancer cells selectively.BRAF mutation is the most common genetic alteration in thyroid tumor development and progression; however, antitumor efficacy of vitamin remains be explored. Methods:The effect on cell proliferation apoptosis was assessed by MTT assay flow cytometry.Xenograft transgenic mouse models were used determine its vivo activity C. Molecular biochemical methods elucidate underlying mechanisms anticancer...
Abstract Background The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival human tumorigenesis, including gastric cancer. PIK3CA mutations amplification are two major causes of overactivation this cancers. However, until work, there was no sound investigation on the association with clinical outcome cancer, particularly latter. Methods Using direct sequencing real-time quantitative PCR, we examined amplification, their clinicopathological...
Abstract The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. aim this study was to explore the role EHF tumorigenesis and its potential as a therapeutic target By using quantitative RT-PCR (qRT-PCR), immunohistochemistry (IHC) fluorescence situ hybridization (FISH) assays, we investigated expression copy number cohort control subjects. Specific siRNAs used determine biologic impacts...
Gastric cancer is one of the most common malignancies worldwide. However, genetic alterations leading to this disease are largely unknown. Gene amplification frequent alterations, which believed play a major role in development and progression gastric cancer. In present study, we identified three frequently amplified genes from 30 candidate using real-time quantitative PCR method, including ERBB4, C-MET CD44, further explored their association with clinicopathological characteristics poor...
Gastric cancer (GC) is one of the most commonly occuring gastrointestinal tumor types, and early diagnosis operation have a notable effect on prognosis patients. Although certain markers, including HER2, VEGER-2, ERCC1 Bcl-2, been utilized in clinical practise to screen out new patients with GC, results using these markers remains poor. The role olfactomedin-like 2B (OLFML2B) as member olfactomedin domain-containing proteins family, remain unclear.In present study, we assessed expression...
Aberrant methylation and miRNA-target-gene regulation function as important mechanisms for gene inactivation in colon carcinogenesis. Although a serious of molecular events (such aberrant alterations genomics epigenetics) have been identified to be related prognostic cancer (CC) patients, beneficial biomarkers early diagnosis evaluation remain largely unknown.In our study, the role NEURL1B, including expression analysis, characteristic, miRNA-target regulation, diagnostic significance, were...
Bcl-2-associated transcription factor-1 (BCLAF1), an apoptosis-regulating protein of paramount significance, orchestrates the progression various malignancies. This study reveals increased BCLAF1 expression in hepatocellular carcinoma (HCC) patients, whom elevated levels are linked to escalated tumor grades and diminished survival rates. Moreover, novel is particularly HCC patients who were not sensitive combined treatment atezolizumab bevacizumab, but had tumors that responded regimen....
The discs large‑associated protein (DLGAP) family has been implicated in psychological and neurological diseases. However, few studies have explored the association between expression of DLGAPs different types cancer. Therefore, present study analyzed status gastric cancer (GC) using bioinformatic tools. Analyses data obtained from Cancer Genome Atlas Gene Expression Omnibus databases revealed that there was selective upregulation DLGAP4 DLGAP5 GC tissues when compared with normal tissues....
Anaplastic thyroid cancer (ATC) is a kind of rare with very poor prognosis. Doxorubicin has been approved in ATC treatment as single agent, but monotherapy still shows no improvement the total survival advanced ATC. Lenvatinib was investigated encouraging results treating patients radioiodine-refractory differentiated (DTC). However, antitumor efficacy combination therapy lenvatinib and doxorubicin remains largely unclear.The on cell proliferation assessed by MTT assay colony formation. Flow...
Abstract Bcl-2-associated transcription factor-1 (Bclaf1), an apoptosis-regulating protein of paramount significance, orchestrates the progression various malignancies. This inquiry reveals heightened expression Bclaf1 in hepatocellular carcinoma (HCC) patients, where its elevated levels are conspicuously linked to escalated tumor grades and diminished survival rates. Moreover, novel exhibits a surge within HCC patients who were not sensitive combined treatment atezolizumab bevacizumab...
Aberrant methylation and miRNA-target-gene regulation function as important mechanisms for gene inactivation in colon carcinogenesis. Although a serious of molecular events (such aberrant alterations genomics epigenetics) have been identified to be ralated prognostic cancer (CC) patients, beneficial biomarkers early diagnosis evaluation remain largely unknown. In our study, the role NEURL1B, including expression analysis, characteristic, miRNA-target regulation, diagnostic significance, were...
Abstract Background: Anaplastic thyroid cancer (ATC) is a kind of rare with very poor prognosis. It one the deadliest cancers in human due to aggressive behavior and resistance treatment. Doxorubicin has been approved ATC treatment as single agent, but monotherapy still shows no improvement total survival advanced ATC. Lenvatinib was investigated encouraging results treating patients radioiodine-refractory differentiated (DTC). However, antitumor efficacy combination therapy lenvatinib...
Abstract Background Anaplastic thyroid cancer (ATC) is a kind of rare with very poor prognosis. It one the deadliest cancers in human due to aggressive behavior and resistance treatment. Doxorubicin has been approved ATC treatment as single agent, but monotherapy still shows no improvement total survival advanced ATC. Lenvatinib was investigated encouraging results treating patients radioiodine-refractory differentiated (DTC). However, antitumor efficacy combination therapy lenvatinib...