A5055243214- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Dietary Effects on Health
- Mechanisms of cancer metastasis
- Thyroid Cancer Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Cancer Mechanisms and Therapy
- Vitamin D Research Studies
- Barrier Structure and Function Studies
- Digestive system and related health
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
Shaanxi Provincial People's Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2017-2021
Background:Vitamin C has been demonstrated to kill BRAF mutant colorectal cancer cells selectively.BRAF mutation is the most common genetic alteration in thyroid tumor development and progression; however, antitumor efficacy of vitamin remains be explored. Methods:The effect on cell proliferation apoptosis was assessed by MTT assay flow cytometry.Xenograft transgenic mouse models were used determine its vivo activity C. Molecular biochemical methods elucidate underlying mechanisms anticancer...
Anaplastic thyroid cancer represents the most aggressive form of and harbors BRAF mutations in over 40% cases. Vemurafenib (PLX4032), a kinase inhibitor, shows promise BRAFV600E-positive advanced but may promote resistance anaplastic This study investigates whether mannose, known to selectively inhibit cancer, enhances PLX4032 efficacy. To evaluate mannose could enhance response cells vemurafenib, we employed several vitro assays including MTT, colony formation, flow cytometry, migration,...
Abstract Background Mannose, a natural hexose existing in daily food, has been demonstrated to preferentially inhibit the progression of tumors with low expression phosphate mannose isomerase (PMI). However, its function thyroid cancer still remains elusive. Methods MTT, colony formation and flow cytometry assays were performed determine response cells mannose. Meanwhile, mouse models subcutaneous xenograft primary papillary established vivo anti-tumor activity The underlying mechanism...
The aim of this study was to investigate copy number ErbB family members (including EGFR, HER2, HER3 and HER4) in a cohort gliomas benign meningiomas (control subjects), explore the associations their with clinicopathological characteristics clinical outcomes glioma patients. Using real-time quantitative PCR assay, we demonstrated that HER4 patients significantly increased compared control subjects. Moreover, our data also showed risk cancer-related death positively associated gain (CNG)...