A5048909322- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Botanical Studies and Applications
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Biomedical Text Mining and Ontologies
- Genomics and Phylogenetic Studies
- Fetal and Pediatric Neurological Disorders
Women's Hospital, School of Medicine, Zhejiang University
2022-2025
Jinan University
2024
Abstract Primary ovarian insufficiency (POI) is a clinical syndrome of dysfunction characterized by premature exhaustion primordial follicles. POI causes infertility, severe daily life disturbances and long-term health risks. However, the underlying mechanism remains largely unknown. We previously identified Basonuclin 1 ( BNC1 ) mutation from large Chinese pedigree found that mice with targeted Bnc1 exhibit symptoms POI. In this study, we plays key roles in reserve maintaining lipid...
Abstract Autoimmune factors play an important role in premature ovarian insufficiency (POI). Human amniotic epithelial stem cells (hAESCs) have recently shown promising treatment effects on chemotherapy-induced POI. However, the therapeutic efficacy and underlying mechanisms of hAESCs autoimmune POI remain to be investigated. In this study, we showed for first time that intravenous transplantation could reside ovary zona pellucida 3 peptide (pZP3) induced mice model at least 4 weeks. improve...
Polycystic ovarian syndrome (PCOS) is an endocrine that affects a large portion of women worldwide. This proteogenomic and functional study aimed to uncover candidate therapeutic targets for PCOS. We comprehensively investigated the causal association between circulating proteins PCOS using two-sample Mendelian randomization analysis. Cis-protein quantitative trait loci were derived from six genome-wide studies (GWASs) on plasma proteome. Genetic associations with obtained large-scale GWAS...