Two new meroterpenoids, penicianstinoids A and B (1 2), eight isocoumarins, peniciisocoumarins A–H (3–10), together with 10 known analogues (11–20) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. The structures absolute configurations of 1–10 determined by interpretation detailed NMR, MS spectroscopic data, X-ray diffraction analyses, modified Mosher's method, calculated electronic circular dichroism data. Compounds 1–4, 7, 8, 10, 12, 13, 16 showed growth inhibition...

Three new indole diterpenes, penicilindoles A–C (1–3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations determined by interpretation of NMR spectroscopic data, HR-ESIMS, X-ray diffraction analysis using Cu Kα radiation. The cytotoxic antibacterial activities evaluated in vitro; penicilindole A (1) showed activity against human A549 HepG2 cell lines with IC50 values 5.5 1.5 μM, respectively.

Three new dihydroisocoumarin penicimarins G–I (1–3), together with one known (4) and three meroterpenoids (5–7), were obtained from a fungus Penicillium citrinum isolated the mangrove Bruguiera sexangula var. rhynchopetala collected in South China Sea. Their structures elucidated by detailed analysis of spectroscopic data. The absolute configuration 1 was determined X-ray diffraction using Cu Kα radiation. configurations 2 3 comparison their circular dichroism (CD) spectra literature. All...

Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (

A new hydrindane derivative, asperhydrindane (1), along with two known sterol analogues [isocyathisterol (2) and ganodermasides D (3)] were isolated from the mangrove-derived fungus Aspergillus terreus GXIMD 03158 attaching to mangrove Acanthus ilicifoius L. The structure of 1 was elucidated based on extensive spectral analysis, HRESIMS, calculated ECD methods. All compounds evaluated for antibacterial activity. result showed that only compound 3 exhibited significant activity against...

Apoptosis signal-regulating kinase 1 (ASK1), a key component of the mitogen-activated protein (MAPK) cascades, has been identified as promising therapeutic target owing to its critical role in signal transduction pathways. In this study, we proposed novel pyridin-2-yl urea inhibitors exhibiting favorable physicochemical properties. The potency these compounds was validated through vitro bioassays. inhibition (IC50) compound 2 1.55 ± 0.27 nM, which comparable known clinical inhibitor,...

Three unusual austins-type meroterpenoids penicianstinoids C-E (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. The structures of 1-3 including absolute configurations determined by detailed NMR, MS spectroscopic data, X-ray diffraction analysis, and calculated electronic circular dichroism data. Penicianstinoid C (1) was first meroterpenoid with a unique 6/6/6/5 rearranged tetracyclic skeleton possessing two spirocyclic moieties...

Four new xanthene derivatives, penicixanthenes A–D (1–4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained the stem of Ceriops tagal. Their structures determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, calculated electronic circular dichroism data. All compounds examined for insecticidal activity. Compounds 2 3 showed growth inhibition activity against newly hatched larvae Helicoverpa armigera...

Four new cyclic pentapeptides, avellanins D–G (1–4), together with four known compounds (5–8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus Acanthus ilicifolius L. Their structures elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. absolute configurations determined X-ray diffraction Marfey’s method. Compounds 1–8 screened for insecticidal antibacterial activities. Compound 2 showed activity against newly hatched larvae Culex quinquefasciatus an...

One new cytochalasin metabolite [11]-cytochalasa-5(6),13-diene-1,21-dione-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*) (1), together with three known compounds (2-4) were obtained from the EtOAc extract of endophytic fungus Daldinia eschscholtzii HJ001 isolated mangrove Brguiera sexangula var. rhynchopetala collected in South China Sea. Their structures elucidated by detailed analysis comprehensive spectroscopic data. Compounds 1 and 2 evaluated for their antibacterial...

Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations determined by detailed NMR, MS spectroscopic data, Mo2(OAc)4-induced electronic circular dichroism (ECD), (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. 2 insecticidal newly hatched larvae Culex quinquefasciatus LC50 78.5 (±0.58)

Five new compounds, including two cyclopiane diterpenes conidiogenones J and K (1-2), a steroid andrastin H (5), an alkaloid (Z)-4-(5-acetoxy-N-hydroxy-3-methylpent-2-enamido) butanoate (6), aliphatic acid (Z)-5-acetoxy-3-methylpent-2-enoic (7), together with ten known compounds (3-4 8-15) were isolated from the EtOAc extract of fermentation broth Lumnitzera littorea-derived fungus Penicillium oxalicum HLLG-13. Their structures elucidated by 1D, 2D NMR, HR-ESI-MS spectral analyses. The...

Three dammarane triterpenoids, cabraleone (20S,24S-eopxy-25-hydroxydammaran-3-one), cabraleadiol (20S,24S-epoxydammarane-3α,25-diol) and shoreic acid (20S,24S-epoxy-25-hydroxy-3,4-secodammar-4(28)-en-3-oicacid), were isolated for the first time from stem bark of Dysoxylum malabaricum Bedd. (Meliaceae). The complete 1H 13C NMR spectral assignment one these compounds, namely cabraleadiol, its 3-O-acetyl derivative achieved by 2D spectroscopy NOE difference spectroscopy. C-20 C-24configurations...

One new meroterpene derivative, millmerranones G (

One new cyclic heptapeptide, cadophorin C (

One new norisoprenoid 3,9-dihydroxy dihydro actinidiolide (1), together with eleven known compounds (2-12), were isolated from ethanol extract of the leaves Ficus pumila collected in Hainan Province, China. Their structures elucidated by detailed analysis comprehensive spectroscopic data. Compounds 1, 2, 4, 5, 8 and 10-12 F. for first time. All evaluated their cytotoxic activity. 3 9 showed weak activity against Hela, MCF-7 A549 cell lines.

A new dihydrochalcone glycoside, phloretin-4-O-β-D-glucopyranoside (1), together with seven known flavonoids (2-8), were isolated from the stems of Homalium stenophyllum. The structure 1 was elucidated by extensive spectroscopic methods and compounds identified comparisons data reported in literature. (2-8) genus for first time. All evaluated their antibacterial activities against six pathogenic bacteria vitro.

An investigation of the leaves Dysoxylum beddomei has yielded a novel triterpene, named beddomeilactone, together with six known triterpenoids: 3-oxotirucalla-7,24-dien-23-ol, dipterocarpol, niloticin, melianone, melianodiol and 24-epi-melianodiol. The structure stereochemistry new compound were determined on basis mass, 1D 2D NMR spectroscopies including NOE difference spin-spin decoupling studies.

Phytochemical investigation of the stems Vatica mangachapoi (Dipterocarpaceae) led to isolation and structural elucidation twenty-seven oligostilbenes (1–27), including a new natural compound 1. The structure 1 was elucidated on basis spectroscopic analyses NMR, MS ECD data, known compounds were identified by comparisons with those reported in literature. absolute configuration first time determined combination NOESY spectrum quantum chemical computation. Among isolates tested for their...

Two new phenolic glycosides (1 and 2) two isocoumarin (3 4), along with 14 known compounds (5-18), were isolated from the stems of Homalium paniculiflorum. Their structures established on basis extensive spectroscopic analyses chemical methods. All evaluated for their anti-inflammatory activities via examining inhibitory activity nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells vitro. Compounds 1 4 exhibited IC50 values 30.23 ± 1.23 μM...