A5102730109- Nuclear Materials and Properties
- Fusion materials and technologies
- High-Temperature Coating Behaviors
- Microbial Natural Products and Biosynthesis
- Photonic and Optical Devices
- High voltage insulation and dielectric phenomena
- Power Transformer Diagnostics and Insulation
- Magnetic Properties and Applications
- Advanced Fiber Optic Sensors
- Structural Engineering and Vibration Analysis
- Structural Load-Bearing Analysis
- Advanced materials and composites
- Landslides and related hazards
- Structural Behavior of Reinforced Concrete
- Seismic Waves and Analysis
- Advanced Fiber Laser Technologies
- earthquake and tectonic studies
- Railway Engineering and Dynamics
- Machine Learning and ELM
- Aluminum Alloys Composites Properties
- Concrete Corrosion and Durability
- Electrowetting and Microfluidic Technologies
- HVDC Systems and Fault Protection
- Spaceflight effects on biology
- Surface Modification and Superhydrophobicity
Anhui Medical University
2021-2025
First Affiliated Hospital of Anhui Medical University
2023-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Sun Yat-sen University
2025
Tsinghua University
2015-2024
Qilu University of Technology
2024
Fujian Agriculture and Forestry University
2024
Guangxi University
2022-2024
Shenyang Ligong University
2022-2024
Jilin Medical University
2024
Abstract The world eagerly needs cleanly-generated electricity in the future. Fusion reactor is one of most ideal energy resources to defeat environmental degradation caused by consumption traditional fossil energy. To meet design requirements fusion reactor, development structural materials which can sustain elevated temperature, high helium concentration and extreme radiation environments biggest challenge for entire material society. Oxide dispersion strengthened steel popular candidate...
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, an RNA-guided nuclease for specific genome editing in vivo, has been adopted a wide variety of organisms. In contrast, the vitro application CRISPR/Cas9 system rarely reported. We present here highly efficient CRISPR/Cas9-mediated (ICE) that allows refactoring biosynthetic gene clusters Streptomyces bacteria and other large DNA fragments. Cleavage by Cas9 circular pUC18 was...
Abstract CD1d-dependent NKT cells have been extensively studied; however, the function of CD8 + NKT-like cells, which are CD1d-independent T with NK markers, remains unknown. Here, we report that express both cell markers (TCRβ and CD3) receptors (NK1.1, CD49b NKG2D), activated significantly expanded in mice immunized GFP-expressing dendritic cells. Distinct from possess a diverse repertoire TCRs secrete high levels IFN-gamma but not IL-4. development is normal CD1d −/− mice, suggests...
During the CoVID-19 pandemic, messenger ribonucleic acid (mRNA) vaccines were developed and approved to curb spread of coronavirus. After over 16 billion-dose-administration Pfizer-BioNTech-Fosun Moderna...
Text-based 3D human motion editing is a critical yet challenging task in computer vision and graphics. While training-free approaches have been explored, the recent release of MotionFix dataset, which includes source-text-motion triplets, has opened new avenues for training, yielding promising results. However, existing methods struggle with precise control, often leading to misalignment between semantics language instructions. In this paper, we introduce related task, similarity prediction,...
Abstract Chondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress considered pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive. Our findings demonstrate that SPI1 plays significant role counteracting and inhibiting OA progression. binds to PERK promoter, thereby promoting its transcriptional activity. Importantly, PERK, rather than GCN2, facilitates eIF2α phosphorylation, activating...
Seven new 18-residue peptaibols, trichorzins A–G (1–7), were isolated from the sponge-derived fungus Trichoderma sp. GXIMD 01001. Their structures and configurations characterized by a comprehensive interpretation of NMR spectroscopic data, MS/MS fragmentation, Marfey's method, ECD analysis. The general sequences are as follows: Ac-Aib1-Ala/Ser2-Ala3-Aib/Iva4-Iva5-Gln6-Aib/Iva7-Val/allo-Ile8-Aib9-Gly10-Leu11-Aib12-Pro13-Leu14-Aib15-Aib16-Gln17-Trpol/Pheol18. obtained compounds assessed for...
Our previous work has demonstrated the high efficiency of CD8+ natural killer T (NKT)-like cells in killing antigen-bearing dendritic cells. To evaluate their role tumor microenvironment, we performed vitro and vivo antitumor experiments to investigate whether CD8+NKT-like could kill Yac-1 B16 like NK EL4-OVA8 an antigen-specific manner cytotoxic lymphocytes (CTLs). Unlike NK1.1-CTLs, also exhibit capability myeloid-derived suppressor (MDSCs) manner, indicative potential clearing MDSCs...
Abstract Streptovaricin C is a naphthalenic ansamycin antibiotic structurally similar to rifamycins with potential anti-MRSA bioactivities. However, the formation mechanism of most fascinating and bioactivity-related methylenedioxy bridge (MDB) moiety in streptovaricins unclear. Based on genetic biochemical evidences, we herein clarify that P450 enzyme StvP2 catalyzes MDB streptovaricins, an atypical substrate inhibition kinetics. Furthermore, X-ray crystal structures complex structure-based...
The identification of chromatic ink particles with characteristics good light stability, bright color, narrow distribution and high surface charge density is important. In this paper, the preparation pigment-based RGB tricolor via mini-emulsion polymerization reported. Narrow distributed are obtained assistance sodium dodecyl benzenesulfonate. Their large quantity confirmed by zeta potential values in range −40–−50 mV. hues all consistent their corresponding pigments after coating...
The streptovaricins, chemically related to the rifamycins, are highly effective antibacterial agents, particularly against mycobacteria. Herein, a bioassay-guided investigation of Streptomyces spectabilis CCTCC M2017417 has led characterization streptovaricins as potent compounds methicillin-resistant Staphylococcus aureus (MRSA). We identified streptovaricin biosynthetic gene cluster from S. based on genomic sequencing and bioinformatic analysis. Targeted in-frame deletion five cytochrome...
This study investigated two overhanging 3-span composite girders to simulate the behavior of a suspension bridge. A new uplift-restricted and slip-permitted T-shape (URSP-T) connector is proposed decrease concrete slab tensile stress in girders. URSP-T connectors installed on one side specimen were compared with studs other side. Various elastic working conditions, ultimate sagging moment hogging conditions employed investigate different connectors. The test results showed that use decreased...
Being aware of the great hazard transformer winding deformation and insulation damage under impact huge electromagnetic forces caused by short circuit faults, this paper presented an analysis method based on explicit dynamic 3-D finite element method, enabling detailed representative investigations mechanical effects external faults in power transformers. Considering displacements deformations windings could change leakage flux distribution further influence remaining computation,...