A5103833128- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- bioluminescence and chemiluminescence research
- RNA regulation and disease
- Animal Genetics and Reproduction
- Trace Elements in Health
- Immune cells in cancer
- Eosinophilic Disorders and Syndromes
- Advanced biosensing and bioanalysis techniques
- Skin and Cellular Biology Research
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Tianjin Medical University Cancer Institute and Hospital
2016-2024
Shanghai Jiao Tong University
2010-2020
Shanghai Sixth People's Hospital
2019
Qingdao University
2008
Abstract Chondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress considered pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive. Our findings demonstrate that SPI1 plays significant role counteracting and inhibiting OA progression. binds to PERK promoter, thereby promoting its transcriptional activity. Importantly, PERK, rather than GCN2, facilitates eIF2α phosphorylation, activating...
ABSTRACT Background Lung squamous cell carcinoma (LUSC) is a type of lung cancer that develops in the cells. It known to be promoted by activation various signaling pathways and dysregulation key regulatory molecules. One such molecule, 5′‐nucleotidase domain containing 2 (NT5DC2), has been identified as critical regulator cancers including cancer. However, there are no data regarding its role LUSC. Methods The mRNA expression insulin‐like growth factor mRNA–binding protein 3 (IGF2BP3),...
To address the concern around efficiency/cytotoxicity ratio and tumor-targeting effects of polyethylenimine (PEI), is a non-viral gene vector used for delivery cancer therapy gene, poloxamer 407 (P407)-PEI-K12, was synthesized by cross-linking low-molecular weight PEI with P407 further coupling bifunctional peptide, K12, which comprised peptide tLyP-1 nuclear localization sequence. Furthermore, addition free into polymer/DNA complex solution produced temperature-sensitive in situ...
Hypopharyngeal carcinoma is one of the most aggressive subtypes squamous cell head and neck. Although significant progress has been made in surgical techniques, radiotherapy, chemotherapy, prognosis still poor. Mesenchymal stem cells (MSCs) have attracted substantial attention as tumor-targeted cellular carriers for cancer gene therapy. We previously shown that recombinant baculovirus-adeno-associated vectors (BV-AAV) possessed high efficiency multi-gene coexpression human bone marrow MSCs...
Vectors that are capable of coexpressing two or more exogenous genes for in vitro and vivo gene delivery being increasingly studied. The aim the present study was to explore feasibility using pFastBac™ Dual vector, under control cytomegalovirus (CMV) promoters with opposite directions, coexpress enhanced green fluorescent protein (EGFP) glial cell line‑derived neurotrophic factor (GDNF) same mammalian cell. In study, pFastBac vector were replaced CMV‑EGFP CMV‑GDNF, whose directions...