A5100784599- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Redox biology and oxidative stress
- Virus-based gene therapy research
- Metal complexes synthesis and properties
- Epigenetics and DNA Methylation
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Plant Disease Resistance and Genetics
- Chemotherapy-induced cardiotoxicity and mitigation
- Curcumin's Biomedical Applications
- Estrogen and related hormone effects
- Immune cells in cancer
- ATP Synthase and ATPases Research
- Metal-Catalyzed Oxygenation Mechanisms
- Invertebrate Immune Response Mechanisms
- Plant-Microbe Interactions and Immunity
Air Force Medical University
2021-2024
Xijing Hospital
2021-2024
California Institute of Technology
2024
Qingdao University
2021
Affiliated Hospital of Qingdao University
2021
Northwest A&F University
2019
Wake Forest University
2018
Shanghai Ocean University
2018
Affiliated Hospital of Jiangsu University
2017
Jiangsu University
2017
Thioredoxin reductase (TrxR), which is overexpressed in many aggressive cancers, plays a crucial role redox balance and antioxidant function, including defense of oxidative stress, control cell proliferation, regulation apoptosis. Deactivation TrxR can destroy the homeostasis cancer cells, inducing elevation reactive oxygen species (ROS) levels oxidation enzymatic substrates. Here, we synthesized identified new gold(I) small molecule (D9) that possesses two strong electron-donating moieties,...
Long noncoding RNAs (lncRNAs) play multiple key roles during inflammatory processes. In this study, a novel lncRNA identified by the high-throughput sequencing analysis was found significantly down-regulated in Escherichia coli-introduced cell model of bovine mastitis. Given that consists antisense leucine-rich repeat-containing protein 75A (LRRC75A), it named LRRC75A lncRNA1 (LRRC75A-AS1). The expression LRRC75A-AS1 mammary epithelial cells and tissues under condition. Knockout (KO)...
Grass carp (Ctenopharyngodon idella) hemorrhagic disease is caused by an acute infection with grass reovirus (GCRV). The frequent outbreaks of this have suppressed development the farming industry. GCRV104, representative strain genotype III reovirus, belongs to Spinareovirinae subfamily and serves as a model for studying GCRV which encodes outer-fiber protein. There no commercially available vaccine GCRV. Therefore, discovery new inhibitors will be clinically beneficial. In addition,...
Abstract Background Tumor cells frequently suffer from endoplasmic reticulum (ER) stress. Previous studies have extensively elucidated the role of tumorous unfolded protein response in melanoma cells, whereas effect on tumor immunology and underlying mechanism remain elusive. Methods Bioinformatics, biochemical assays pre-clinical mice model were employed to demonstrate inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) anti-tumor immunity mechanism. Results We firstly found...
Reactive oxygen species (ROS) play an important role in cellular metabolism. Many chemotherapeutic drugs are known to promote apoptosis through the production of ROS. In present study, novel curcumin derivative, 1g, was found inhibit tumor growth colon cancer cells both vitro and vivo . Bioinformatics used analyze differentially expressed mRNAs. The mechanism this effect a change mitochondrial membrane potential caused by 1g that increased its pro-apoptotic activity. addition, produced ROS,...
ABSTRACT Background Lung squamous cell carcinoma (LUSC) is a type of lung cancer that develops in the cells. It known to be promoted by activation various signaling pathways and dysregulation key regulatory molecules. One such molecule, 5′‐nucleotidase domain containing 2 (NT5DC2), has been identified as critical regulator cancers including cancer. However, there are no data regarding its role LUSC. Methods The mRNA expression insulin‐like growth factor mRNA–binding protein 3 (IGF2BP3),...
Two Gram-stain-negative bacterial strains, R39 T and R73 , were isolated from the rhizosphere soil of selenium hyperaccumulator Cardamine hupingshanesis in China. Strain transformed selenite into elemental volatile selenium, whereas strain both selenate selenium. Phylogenetic phylogenomic analyses indicated that belonged to genus Achromobacter while Buttiauxella . (genome size, 6.68 Mb; G+C content, 61.6 mol%) showed closest relationship marplatensis LMG 26219 kerstersii 3441 with average...
Introduction Low‐grade systemic inflammation associates with both postmenopause and the development of heart failure (HF). Given that markers oxidative stress predict incident HF, may have a direct effect on estrogen‐deficient myocardium, possibly through increased stress. In ovariectomized (OVX) models aging hypertension, we've shown estradiol (E2) or activation G‐protein coupled estrogen receptor, GPER, by its specific agonist G1, improves diastolic function limits left ventricular (LV)...