A5009361304- RNA and protein synthesis mechanisms
- Nanopore and Nanochannel Transport Studies
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Proteins in Food Systems
- Electrocatalysts for Energy Conversion
- Metabolism, Diabetes, and Cancer
- Metal-Catalyzed Oxygenation Mechanisms
- Biochemical and Structural Characterization
- Protein Structure and Dynamics
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Hemoglobinopathies and Related Disorders
- Growth Hormone and Insulin-like Growth Factors
- TGF-β signaling in diseases
- Advanced biosensing and bioanalysis techniques
- Surfactants and Colloidal Systems
- Fuel Cells and Related Materials
- Carbon Nanotubes in Composites
- Force Microscopy Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Bacteriophages and microbial interactions
- Pickering emulsions and particle stabilization
- Studies on Chitinases and Chitosanases
Yunnan University
2025
Tsinghua University
2020-2024
Beijing Advanced Sciences and Innovation Center
2021
Institute of High Energy Physics
2014-2017
Chinese Academy of Sciences
2015-2017
Zhejiang University
2017
Hebei University of Technology
2010
Abstract Metformin is a widely used first-line antidiabetic drug that has been shown to protect against variety of specific diseases in addition diabetes, including cardiovascular disorders, polycystic ovary syndrome and cancer. However, the precise mechanisms underlying diverse therapeutic effects metformin remain elusive. Here, we report transforming growth factor-β1 (TGF-β1), which involved pathogenesis numerous diseases, novel target metformin. Using surface plasmon resonance-based...
Abstract The fluorescent light-up aptamer RhoBAST, which binds and activates the fluorophore–quencher conjugate tetramethylrhodamine-dinitroaniline with high affinity, super brightness, remarkable photostability, fast exchange kinetics, exhibits excellent performance in super-resolution RNA imaging. Here we determine co-crystal structure of RhoBAST complex to elucidate molecular basis for ligand binding fluorescence activation. an asymmetric “A”-like architecture a semi-open pocket harboring...
In this study, a sulfur-doped cobalt–iron catalyst (CoFeS/NF) was synthesized on nickel foam (NF) substrate via facile one-step electrodeposition method, and its performance in urea electrolysis for hydrogen production systematically investigated. Sulfur doping induced significant morphology optimization, forming highly dispersed nanosheet structure, which enhanced the specific surface area increase by 1.9 times compared with undoped sample, exposing abundant active sites. Meanwhile,...
Abstract Human RNA binding protein Musashi-1 (MSI1) plays a critical role in neural progenitor cells (NPCs) by to various host transcripts. The canonical MSI1 site (MBS), A/GU (1-3) AG single-strand motif, is present many virus genomes, but only Zika (ZIKV) genome has been demonstrated bind MSI1. Herein, we identified the AUAG motif and AGAA tetraloop Xrn1-resistant 2 (xrRNA2) as non-canonical MBS, respectively, both are crucial for ZIKV neurotropism. More importantly, unique AGNN-type...
Thioredoxin reductase (TrxR), which is overexpressed in many aggressive cancers, plays a crucial role redox balance and antioxidant function, including defense of oxidative stress, control cell proliferation, regulation apoptosis. Deactivation TrxR can destroy the homeostasis cancer cells, inducing elevation reactive oxygen species (ROS) levels oxidation enzymatic substrates. Here, we synthesized identified new gold(I) small molecule (D9) that possesses two strong electron-donating moieties,...
When stabilized and functionalized by biomolecules, noble metal (such as gold silver) cluster-based hybrid nanocomposites have shown great promise for biomedical applications, due to their unique physiochemical properties originating from the inorganic elements specific functionality biocompatibility biological components. Although certain bioimaging, biosensing, biomimetic catalysis has been demonstrated, it is still a challenge integrate defined of biomolecules with enhanced or novel...
Abstract T-box riboswitches are unique riboregulators where gene regulation is mediated through interactions between two highly structured RNAs. Despite extensive structural insights, how RNA-RNA drive the folding and transitions of to achieve functional conformations remains unclear. Here, by combining SAXS, single-molecule FRET computational modeling, we elaborate energy landscape a translational aptamer consisting stems I, II IIA/B, which Mg 2+ -induced global tRNA binding cooperatively...
Abstract Mechanical anisotropy is an essential property for many biomolecules to assume their structures, functions and applications, however, the mechanisms direction-dependent mechanical responses remain elusive. Herein, by using a single-molecule nanopore sensing technique, we explore of directional stability xrRNA1 RNA from ZIKA virus (ZIKV), which forms complex ring-like architecture. We reveal extreme in ZIKV highly depends on Mg 2+ key tertiary interactions. The absence disruption...
φ29 motor’s three-way junction serves as an effective connecting rod through its superb rigidity in the coaxial direction.
An assortment of biological processes, like protein degradation and the transport proteins across membranes, depend on unfolding events mediated by nanopore interfaces. In this work, we exploit fully atomistic simulations an artificial, CNT-based to investigate nature ubiquitin unfolding. With one end subjected external force, observe non-canonical behaviour as is pulled through pore opening. Secondary structural elements are sequentially detached from threaded into nanotube, interestingly,...
Foam fractionation is a promising technology for protein concentration or purification. However, the presence of an antifoam agent in fermentation broth restricted direct application technology. A preliminary approach surfactant-assisted foam process was conducted with simulated system consisting targeted bovine serum albumin (BSA), and mixed (AF520, silicon oil/PGE mixture). The effects all three classes surfactants (anionic SDBS, cationic CTAB, non-ionic Tween-20) on BSA were examined...
Mechanical anisotropy is an essential property for many biomolecules to assume their structures, functions and applications, however, the mechanisms direction-dependent mechanical responses remain elusive. Herein, by using single-molecule nanopore sensing technique, we explore of directional stability xrRNA1 RNA from ZIKA virus (ZIKV), which forms a complex ring-like architecture. We reveal extreme in ZIKV highly depends on Mg 2+ key tertiary interactions. The absence disruption interactions...