A5101992712- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Anorectal Disease Treatments and Outcomes
- Uterine Myomas and Treatments
- Urological Disorders and Treatments
- Pregnancy-related medical research
- Tissue Engineering and Regenerative Medicine
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Colorectal Cancer Surgical Treatments
- Sperm and Testicular Function
- Ovarian function and disorders
- Reproductive Physiology in Livestock
- TGF-β signaling in diseases
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Renal and related cancers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Acupuncture Treatment Research Studies
- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Biomedical Ethics and Regulation
Wuhan University
2025
Stanford University
2012-2024
Palo Alto University
2006-2024
First People's Hospital of Yunnan Province
2018-2020
Stanford Medicine
1998-2020
Kunming University of Science and Technology
2020
Palo Alto Institute
2018
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2016
Tianjin University of Traditional Chinese Medicine
2015
Shandong University
2014
Allergen specific CD4+ T cell clones generated from allergic individuals have been shown to produce increased levels of the cytokine interleukin 4 (IL-4), compared allergen nonallergic individuals. This difference between cells and with regard production in response is thought be responsible for development disease IgE synthesis atopic We examined IL-4 subjects rhinitis treated immunotherapy, a treatment which involves subcutaneous administration increasing doses highly effective beneficial...
GnRH is one of the paracrine/autocrine regulators hCG secretion produced by human trophoblast during pregnancy. We hypothesized that may play a role in embryonic/endometrial dialogue early implantation. To examine this hypothesis, we assessed and GnRH-receptor mRNA protein expression endometrium throughout menstrual cycle premenopausal fertile patients. Quantitation was performed reverse transcription (RT)-competitive polymerase chain reaction (PCR) presence competitive cDNA fragment. RT-PCR...
Abstract Aims Weakening of pelvic supportive tissues is thought to be a contributing etiology in female floor disorders such as stress urinary incontinence and/or organ prolapse (SUI/POP). Since elastin modulates the mechanical properties tissues, we examined elastase activity vaginal tissue from women with dysfunction compared asymptomatic controls, by comparing overall activity, human neutrophil elastase, cathepsin K, and alpha‐1 antitrypsin (a serine protease inhibitor) mRNA protein...
Previous studies have established the presence of an extrahypothalamic GnRH in a variety tissues. receptor is known to be present placenta, which produces and secretes decapeptide from very early stages placentation. We hypothesized that may play role preimplantation development embryos. To examine this hypothesis, we assessed messenger RNA (mRNA; RT-PCR) protein expression (Immunohistochemistry) murine embryos at various developmental stages. Furthermore, were cultured with agonist...
Interleukin-1 (IL-1) is expressed in human endometrium and has been shown to play an integral role local cellular interactions during implantation. In addition, the matrix metalloproteinase (MMP) its inhibitor, tissue inhibitor of (TIMP), are crucial implantation, mediating vitro trophoblast penetration, regulated by several cytokines cells. We have investigated roles IL-1β transforming growth factor-β (TGFβ) regulating TIMP-1, TIMP-3, 92-kDa type IV collagenase messenger ribonucleic acid...
The pelvic tissue of women with organ prolapse is stiffer than that controls but there are scant data on the collagen composition corresponds to these mechanical properties. We evaluated human vaginal wall stiffness using novel scanning haptic microscope and correlated measurements expression in without prolapse. In this simultaneous biomechanical biochemical assessment we usefulness measurement technology for floor disorder research confirmed an association between properties composition.
There is great interest in using stem cells (SC) to regenerate a deficient urethral sphincter patients with urinary incontinence. The smooth muscle component of the significant contributor function. However, current translational efforts for restoration focus only on skeletal regeneration because they rely adult mesenchymal SC as cell source. These do not yield sufficient (SMCs) transplantation. We may be able overcome this limitation by pluripotent (PSC) derive SMCs. Hence, we sought...
Numerous randomized controlled trials (RCTs) of acupuncture have been conducted in recent years. The results several studies implied that was only a powerful placebo; however, certain demonstrated verum had greater effect than placebo and the mechanisms between group placebo/sham were different. Researchers attempted to investigate inherent factors may potentially influence trials. Certain problems observed RCTs also occurred other fields, including insufficient sample size, high dropout...
Gathering knowledge about the molecular events during preimplantation development is one of most important challenges in in-vitro fertilization (IVF). The interleukin-1 (IL-1) system has been shown to be intimately involved embryonic implantation. aim our study was detect major components IL-1 single blastomeres from human embryos and relate findings further biopsied vitro. Single were removed morphologically normal obtained dipronuclear zygotes examined by reverse transcription (RT)-nested...
The interleukin-1 (IL-1) system has been shown to play an important role in human and murine embryo implantation. Recent studies have documented immunohistochemical evidence of interleukin-1β (IL-1β), receptor antagonist (IL-1ra) type I (IL-1R tI) preimplantation embryos protein levels interleukin-1α (IL-1α), IL-1β IL1ra culture fluid correlated with successful implantation pregnancy. Our aim this study was detect IL-1β, IL-1ra IL-1R tI mRNA single mouse describe the frequency positive...
BACKGROUND: The pathophysiology of pelvic floor dysfunction resulting in stress urinary incontinence (SUI) women is complex. Evidence suggests that there also a genetic predisposition towards SUI. We sought to identify differentially expressed genes involved extracellular matrix (ECM) metabolism vaginal tissues from with SUI the secretory phase menses compared asymptomatic women. METHODS: Tissue samples were taken periurethral wall five pairs premenopausal, age-matched and continent...
Early human trophoblast shows dramatic invasive properties during early pregnancy. The simultaneous synthesis of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) in both decidual membranes suggests that controlled balanced expression is crucial for the rapid remodeling invasion Recently, we have described presence an extrahypothalamic GnRH immunologically, biologically chemically identical to hypothalamic hormone periimplantation embryos. Moreover, production...