A5065181106- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Antioxidant Activity and Oxidative Stress
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Quinazolinone synthesis and applications
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Animal Nutrition and Physiology
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Skin Protection and Aging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
First People's Hospital of Yunnan Province
2014-2023
Kunming University of Science and Technology
2018-2023
Yunnan Provincial Infectious Disease Hospital
2023
Yunnan Center for Disease Control And Prevention
2022
China Academy of Space Technology
2015-2016
Nanjing Agricultural University
2003-2016
Henan Agricultural University
2014
China Aerospace Science and Technology Corporation
2012
Johnson & Johnson (United States)
2009
Princeton University
2000
Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number of genes regulated by the p53 transcription factor. Responses DNA damage and zinc-inducible compared for their patterns in cell culture. A cluster analysis these data demonstrates that induced gamma radiation, UV zinc-induced form distinct sets subsets with few common all treatments. Cell type- or line-specific responses detected. When proteins zinc, kinetics induction repression mRNAs p53-responsive fell...
ABSTRACT The hedgehog (hh) segmentation gene of Drosophila melanogaster encodes a secreted signaling protein that functions in the patterning larval and adult structures. Using low stringency hybridization degenerate PCR primers, we have isolated complete or partial hh-like sequences from range invertebrate species including other insects, leech sea urchin. We also three mouse two human DNA fragments encoding distinct sequences. Our studies focused upon Hhg-1, with 46% amino acid identity to...
Single nucleotide polymorphism (SNP) genotyping is playing an increasing role in genome mapping, pharmacogenetic studies, and drug discovery. To date, genome-wide scans studies involving thousands of SNPs samples have been hampered by the lack a system that can perform with cost-effective throughput, accuracy, reliability. address this need, Orrhid has developed automated, ultra-high throughput system, SNPstream UHT, which uses multiplexed PCR conjunction our next generation SNP-IT tag array...
FTO (fat mass and obesity associated gene) was genetically identified to be with body index (BMI), presumably through functional regulation of energy homeostasis. However, the cellular molecular mechanisms by which functions remain largely unknown. Using 3T3-L1 preadipocyte as a model study role in adipogenesis, we demonstrated that is functionally required for differentiation. knock-down siRNA inhibited differentiation, whereas ectopic over-expression enhanced process. The demethylase...
N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure human FTO with 1a reveals a novel binding site for defines molecular basis recognition by inhibitor. identification new offers opportunities further development selective potent inhibitors FTO, which expected provide information concerning therapeutic targets treatment or obesity-associated diseases.
FeII and α-ketoglutarate-dependent fat mass obesity associated protein (FTO)-dependent demethylation of m6A is important for regulation mRNA splicing adipogenesis. Developing FTO-specific inhibitors can help probe the biology FTO unravel novel therapeutic targets treatment or obesity-associated diseases. In present paper, we have identified that 4-chloro-6-(6′-chloro-7′-hydroxy-2′,4′,4′-trimethyl-chroman-2′-yl)benzene-1,3-diol (CHTB) an inhibitor FTO. The crystal structure CHTB complexed...
BackgroundOrelabrutinib is a novel, small molecule, selective irreversible Bruton tyrosine kinase inhibitor. The purpose of this study was to evaluate the efficacy and safety orelabrutinib in patients with relapsed or refractory Waldenström's macroglobulinemia (R/R WM).MethodsThis prospective, multicenter WM who had at least one prior line treatment. Orelabrutinib administered orally daily dose 150 mg until disease progression unacceptable toxicity. primary endpoint major response rate (MRR)...
Introduction Is there a difference in pathogen infection among sepsis patients with different organ dysfunction and Post-sepsis persistent dysfunction? this related to survival? It is currently unclear. Methods This study reviewed 1982 between December 2019 September 2023, included 619 after removing missing data. Of these, 332 were tested for metagenomic next-generation sequencing (mNGS). First, the pathogens distribution was assessed all NGS-positive patients, followed by (excluding those...
Growth/differentiation factor-10 (GDF-10) is a TGF-β family member highly related to bone morphogenetic protein-3. In order determine the biological function of GDF-10, we carried out detailed analysis expression pattern GDF-10 and characterized GDF-10-null mice that generated by gene targeting. During embryogenesis expressed prominently in developing skeletal structures both craniofacial region vertebral column. adult animals, at high levels brain, where localized primarily cells Purkinje...
Relapsed or refractory (r/r) mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a poor prognosis. Bruton tyrosine kinase (BTK) mediator of receptor signaling and associated the development lymphomas. Patients r/r MCL were enrolled in this phase 1/2 study treated orelabrutinib, novel, highly selective BTK inhibitor. The median number prior regimens was 2 (range, 1-4). age 62 years 37-73 years). Eligible patients received oral orelabrutinib 150 mg once daily (n = 86) 100 twice...
Coenzyme Q(10) (CoQ(10) ) is a well-known antioxidant and has been used in many skincare products for anti-ageing purpose. However, the molecular mechanisms of CoQ(10) function skin cells are not fully understood. In this paper, we compared effects on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that treatment promoted proliferation fibroblasts, increased type IV collagen expression reduced UVR-induced matrix metalloproteinases-1 (MMP-1) level...
Abstract Bruton's tyrosine kinase (BTK) as a therapeutic target for B-cell malignancies, including mantle cell lymphoma (MCL), chronic lymphocytic leukemia/small (CLL/SLL) and other non-Hodgkin's lymphomas (NHL), has been clinically validated. Orelabrutinib (ICP-022) is novel, potent highly selective BTK inhibitor with excellent pharmacokinetics/pharmacodynamics (PK/PD) properties distinguished from inhibitors. Here we report the results preclinical studies, together safety PK/PD data in...
In this study, the complete mitochondrial genome sequence of Algerian honeybee, Apis mellifera intermissa, is analyzed for first time. The results show that 16,336 bp in length, and contains 13 protein-coding genes, 22 transfer RNA 2 ribosomal 1 control region (D-loop). overall base composition A (43.2%), C (9.8%), G (5.6%), T (41.4%), so percentage (84.6%) considerably higher than C. All genes are encoded on H-strand, except four subunit (ND1, ND4, ND4L, ND5), two rRNA (12S 16S rRNA), eight...
The fat mass and obesity associated (FTO) gene, which encodes a demethylase of m6A, has been reported to respond lipopolysaccharide (LPS) serve as link between inflammation metabolic responses. objective this study was determine whether LPS-induced changes in the expression FTO genes are with alterations m6A relevant mRNAs. LPS challenge significantly decreased hepatic mRNA carnitine palmitoyl transferase 1 (CPT1) CPT2, coincided tendency higher triglyceride accumulation liver....
Non-Hodgkin’s lymphoma (NHL) is a form of tumor that originates in the lymphoid tissues. Bacterial infections are very common NHL patients. Because most patients do not experience apparent symptoms during initial stage infection, it difficult to detect underlying condition before progresses more critical level. The activation cytokines hallmark inflammation. Due advantages short detection time and high sensitivity cytokines, many studies have focused on relationship between infection....
Slightly more than half of all human cancers sustainmutations in the p53 gene (Hollstein et al. 1991; Bennettet 1992), and germ-line mutations this lead tovarious types (Malkin 1990). The wildtype can block cellular transformation by activated oncogenes vitro (Finlay 1989) tumorcell growth vivo (Shaw 1992; Xu 1997). Anormal cell maintains low levels protein. Thelevels transcriptional activity proteinincrease response to stress, such as DNA damage, activation oncogenes, viral infection,...
The effect of dietary 18:2n-6/18:3n-3 ratio (by the replacement corn oil with linseed oil) on n-3 polyunsaturated fatty acids (PUFA) enrichment in breast muscle broiler chickens and expression lipogenic genes were investigated. Broiler fed ad libitum diets containing 5% (CO), 3.75% + 1.25% (CL1), 2.5% (CL2), (LO) based basic diets, respectively. Dietary did not affect 42-day body weight 0-42-day feed conversion efficiency (feed/gain, P > 0.05) chickens, however, significantly increased...
The effect of different levels corn oil (CO) and flaxseed (FO) on growth performance, blood characteristics, fatty acid composition, expression lipogenic genes in the liver broiler chickens was studied. Two hundred forty female Cobb-500 at age one day (body weight (BW) = 46 ± 4 g) were fed a soybean meal based diet containing 5% CO (LC), 3.75% + 1.25% FO (FO1), 2.5% (FO2) or (FC). Chickens FO1 had better BW gain (P 0.049) gain/feed ratio 0.006) than those LC FC diets during days 1-21 age....