A5015134725- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Medical Imaging and Pathology Studies
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Cryospheric studies and observations
- Neuroscience of respiration and sleep
- Aeolian processes and effects
- Pain Mechanisms and Treatments
- Voice and Speech Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Geology and Paleoclimatology Research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Climate change and permafrost
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Air Quality and Health Impacts
- Computational Drug Discovery Methods
- Maternal Mental Health During Pregnancy and Postpartum
Shanghai East Hospital
2024-2025
Tongji University
2024-2025
Guangzhou Medical University
2021-2024
Beijing Normal University
2024
First Affiliated Hospital of Guangzhou Medical University
2021-2024
Heze Medical College
2015-2022
University of Chinese Academy of Sciences
2017-2022
Center for Excellence in Brain Science and Intelligence Technology
2017-2022
Chinese Academy of Sciences
2005-2021
Shenyang Institute of Automation
2009-2021
Serotonergic neurons play key roles in various biological processes. However, circuit mechanisms underlying tight control of serotonergic remain largely unknown. Here, we systematically investigated the organization long-range synaptic inputs to and GABAergic dorsal raphe nucleus (DRN) mice with a combination viral tracing, slice electrophysiological, optogenetic techniques. We found that DRN receive comparable from six major upstream brain areas. Upon further analysis fine functional...
Long-lasting negative affections dampen enthusiasm for life, and dealing with affective states is essential individual survival. The parabrachial nucleus (PBN) thalamic paraventricular (PVT) are critical modulating in mice. However, the functional roles of PBN-PVT projections remain elusive. Here, we show that PBN neurons send dense projection fibers to PVT form direct excitatory synapses neurons. Activation pathway induces robust behaviors associated without affecting nociceptive behaviors....
Spinal gastrin-releasing peptide receptor-expressing (GRPR+) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying modulation of spinal GRPR+ by direct local and long-range inhibitory inputs remain elusive. Using viral tracing electrophysiological approaches, we dissected neural circuits control neurons. We found that galanin+ GABAergic form synapses with cord important gating neuron-dependent signaling pathway. also receive from expressing...
Various types of protected areas (PAs) are important for biodiversity conservation and essential the 2050 Vision Biodiversity. Rapid urban expansion affects effectiveness PAs in many ways. However, we still lack a clear understanding spatial relationship between different China during last 30 years. Here, analyzed spatiotemporal changes such based on boundaries 2622 terrestrial PAs, as well local Moran's Kruskal-Wallis H test period 1992–2020 at national, regional provincial scales. The...
In idiopathic pulmonary fibrosis (IPF) patients, alveolar epithelium architectures are persistently lost and lung gas transfer function would decline over time, which cannot be rescued by conventional anti-fibrotic therapy. P63+ airway basal progenitor cells previously reported to have great potential repair damaged epithelium. Here, we successfully cloned expanded the autologous from IPF patients manufacture cell therapeutic product REGEND001, were further characterized morphology...
Irreversible damage of the lung epithelium in idiopathic pulmonary fibrosis (IPF) patients causes high mortality worldwide, with no repair approaches available currently. Here we show that murine and monkey models, KRT5+ P63+ progenitor cells airway basal layer can enter alveolar area post fibrotic injury. Aided an automated culture system, clone characterize from 44 donors various conditions. Transplantation human into mouse efficiently re-epithelializes injured area, forms new respiratory...
Background: In idiopathic pulmonary fibrosis (IPF) patients, alveolar architectures are lost and gas transfer function would decline, which cannot be rescued by conventional anti-fibrotic therapy. P63+ lung basal progenitor cells reported to have potential repair damaged epithelium in animal models, need further investigation clinical trials. Methods: We cloned expanded from IPF patients manufacture cell product REGEND001, were characterized morphology single-cell transcriptomic analysis....
Chronic cough is a common refractory symptom of various respiratory diseases. However, the neural mechanisms that modulate sensitivity and mediate chronic remain elusive. Here, we report GABAergic neurons in lateral/ventrolateral periaqueductal gray (l/vlPAG) suppress processing via descending pathway. We found l/vlPAG are activated by coughing-like behaviors tussive agent-evoked impaired after activation neurons. In addition, showed form inhibitory synapses with nucleus solitary tract (NTS)...
Transcribing dysarthric speech into text is still a challenging problem for the state-of-the-art techniques or commercially available recognition systems. Improving accuracy of recognition, this paper adopts Deep Belief Neural Networks (DBNs) to model distribution signal. A continuous system produced, in which DBNs are used predict posterior probabilities states Hidden Markov Models (HMM) and Weighted Finite State Transducers framework was utilized build decoder. Experimental results show...
<h2>Summary</h2> Norepinephrine (NE) neurons in the locus coeruleus (LC) play key roles modulating sleep and wakefulness. Recent studies have revealed that paraventricular thalamic nucleus (PVT) is a critical wakefulness-controlling mice. However, effects of NE on PVT remain largely unknown. Here, we investigated mechanisms wakefulness by using viral tracing, behavioral tests, slice electrophysiology, optogenetics techniques. We found PVT-projecting LC had few collateral projections to other...
Upper-middle reaches of Luanhe River Basin belongs to Haihe and it is a pretty important water source North China, especially Tianjin Tangshan Cities, Hebei. Based on control units the function areas sub-basins working were produced. The index system for environmental risk hazard was constructed by adopting pressure state response (PSR) analysis model. environment sources are identified, their grade assessment performed. In an system, namely “downstream characteristics sources” added taking...
ABSTRACT The temperature of snow at 10 discrete vertical levels in the pack was measured using automatic recorders min intervals following 5 snowfalls between January and March 2009 Tianshan Station for Snow Cover Avalanche Research. amplitude diurnal fluctuation during measurement run 2009, when melting, 1.85 times greater than 15 February, accumulating. Analysis gradient all five runs shows that a maximum value surface. 21 4.46 February. approximately zero 30 cm below characteristics daily...
Prenatal stress (PS) causes anxiety in mothers and their offspring chewing is a commonly observed behavior during maternal stress. Prolactin (PRL) an anti-anxiety factor that suppresses the hypothalamic-pituitary-adrenal axis. Here, we studied roles of PRL, corticosterone (CORT), receptors PS-induced anxiety-like dams offspring. We further investigated whether could prevent harmful consequences. Pregnant rats were randomly divided into PS, PS + chewing, control groups. Anxiety-like behaviors...