A5061753651- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Management, Economics, and Public Policy
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Retinal Development and Disorders
- Acoustic Wave Phenomena Research
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
Georgia Institute of Technology
2020-2025
Emory University
2020-2025
University of Tübingen
2022
Senckenberg Centre for Human Evolution and Palaeoenvironment
2016-2022
Bernstein Center for Computational Neuroscience Tübingen
2018-2020
Learning critically depends on the ability to rapidly form and store non-overlapping representations of external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization firing fields upon contextual manipulations. To explore mechanisms underlying such global remapping, we juxtacellularly stimulated 42 neurons freely moving mice during spatial exploration. We found that evoking spike trains silent was sufficient for creating...
Neurons coding for head-direction are crucial spatial navigation. Here we explored the cellular basis of in rat dorsal presubiculum (PreS). We found that layer2 is composed two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted contralateral PreS retrosplenial cortex, respectively. Layer3 pyramidal neurons projected to medial entorhinal cortex (MEC). By juxtacellularly recording awake rats during passive-rotation, responses were preferentially...
A fundamental task of the visual system is to respond both increases and decreases luminance with action potentials (ON OFF responses1-4). responses are stronger, faster, more salient than ON in primary cortex (V1) cats5,6 primates,7,8 but ferrets9 mice,10 can be weaker,11 or balanced12 comparison responses. These discrepancies could arise from differences species, experimental techniques, stimulus properties, particularly retinotopic location field, as has been speculated;9 however, role...
Plasticity within hippocampal circuits is essential for memory functions. The CA2/CA3 region thought to be able rapidly store incoming information by plastic modifications of synaptic weights its recurrent network. High-frequency spike-bursts are believed this process, serving as triggers plasticity. Given the diversity pyramidal neurons, it currently unknown whether and how burst activity, assessed <i>in vivo</i> during natural behavior, relates principal cell heterogeneity. To explore...
Our internal sense of direction is thought to rely on the activity head-direction (HD) neurons. We find that mouse dorsal presubiculum (PreS), a key structure in cortical representation HD, displays modular "patch-matrix" organization, which conserved across species (including human). Calbindin-positive layer 2 neurons within "matrix" form recurrent microcircuits, while inputs from anterodorsal and laterodorsal thalamic nuclei are non-overlapping target "patch" compartments, respectively....
Head-direction (HD) neurons are thought to provide the mammalian brain with an internal sense of direction. These cells, which selectively increase their firing when animal's head points in a specific direction, use spike rate encode HD high signal-to-noise ratio. In present work, we analyzed train features presubicular cells recorded juxtacellularly passively rotated rats. We found that could be classified into two groups on basis propensity fire spikes at short interspike intervals....
To support navigation, the firing of head direction (HD) neurons must be tightly anchored to external space. Indeed, inputs from landmarks can rapidly reset preferred HD cells. Landmark stimuli have often been simulated as excitatory “visual cells” (encoding landmark information) attractor network; when visual are sufficiently strong, directions switch abruptly location. In present work, we tested whether mimicking such via juxtacellular stimulation would sufficient for shifting tuning...
Lateral inhibition is a central principle for sensory system function. It thought to operate by the activation of inhibitory neurons that restrict spatial spread excitation. Much work on role in systems has focused visual cortex; however, neurons, computations, and mechanisms underlying cortical lateral remain debated, its importance perception remains unknown. Here, we tested how from PV or SST mouse primary cortex (V1) modulates neural perceptual sensitivity stimulus contrast. reduced...
Abstract A fundamental task of the visual system is to respond luminance increments and decrements. In primary cortex (V1) cats primates, decrements elicit stronger, faster, more salient neural activity (OFF responses) than (ON responses). However, studies V1 in ferrets mice show that ON responses may be stronger. These discrepancies arise from differences species, experimental conditions, or measuring single neurons versus populations. Here, we examined OFF across different regions space...