A5020075671- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Animal Nutrition and Physiology
- Livestock and Poultry Management
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Veterinary Equine Medical Research
- Antibiotics Pharmacokinetics and Efficacy
- Helminth infection and control
- Effects of Environmental Stressors on Livestock
- Platelet Disorders and Treatments
- Blood groups and transfusion
- melanin and skin pigmentation
- Plant Toxicity and Pharmacological Properties
- Gene expression and cancer classification
- Blood Coagulation and Thrombosis Mechanisms
- Parasites and Host Interactions
- Meat and Animal Product Quality
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Rangeland Management and Livestock Ecology
- Glycosylation and Glycoproteins Research
- Genetic Syndromes and Imprinting
Swedish University of Agricultural Sciences
2015-2024
Skåne University Hospital
2019
Uppsala University
2013
Science for Life Laboratory
2011
Lund University
2004-2008
Helsingborgs lasarett
2007
North Carolina State University
2003-2007
Atkins (United States)
2004
University of Groningen
2001
Dermal hyperpigmentation or Fibromelanosis (FM) is one of the few examples skin pigmentation phenotypes in chicken, where most other variants influence feather color and patterning. The Silkie chicken widespread well-studied breed displaying this phenotype. presence dominant FM allele results extensive dermal layer majority internal connective tissue. Here we identify causal mutation as an inverted duplication junction two genomic regions separated by more than 400 kb wild-type individuals....
To understand the genetic mechanisms leading to phenotypic differentiation, it is important identify genomic regions under selection. We scanned genome of two chicken lines from a single trait selection experiment, where 50 generations have resulted in 9-fold difference body weight. Analyses nearly 60,000 SNP markers showed that effects on are dramatic. The were fixed for alternative alleles more than as result Another 10 displayed strong evidence ongoing differentiation during last...
Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but genome landscapes remain understudied. Here, we present a comprehensive resource for ovine species, landraces improved breeds domestic sheep, comprising high-coverage (∼16.10×) whole genomes 810 samples from 7 species 158 diverse populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 which are novel. Some display significant (P <...
Abstract Background Thousands of years natural and artificial selection have resulted in indigenous cattle breeds that are well-adapted to the environmental challenges their local habitat thereby considered as valuable genetic resources. Understanding background such adaptation processes can help us design effective breeding objectives preserve improve commercial cattle. To identify regions under putative selection, GGP HD 150 K single nucleotide polymorphism (SNP) arrays were used genotype...
Abstract Sheep are among the earliest domesticated livestock species, with a wide variety of breeds present today. However, it remains unclear how far back this diversity goes, formal documentation only dating few centuries. North European short-tailed (NEST) often assumed to be oldest domestic sheep populations, even thought represent relicts expansions during Neolithic period reaching Scandinavia &lt;6,000 years ago. This study sequenced genomes (up 11.6X) five from Baltic islands...
Phytoplankton communities reveal an astonishing biodiversity, whereas classical competition theory seems to suggest that only a few competing species can survive. Recently we suggested new solution this plankton paradox. In theory, at least, between multiple generate complex dynamics support large number of species. How likely is it then, in reality, competitive chaos indeed promotes biodiversity? To obtain some insight, simulated multispecies according five different physiological...
This study aimed at investigating the genetic diversity, relationship and population structure of 110 local Swedish chickens derived from five breeds (Gotlandshöna, Hedemorahöna, Öländsk dvärghöna, Skånsk blommehöna, Bohuslän- Dals svarthöna, in rest paper shorter name Svarthöna is used) using 24 microsatellite markers. In total, one hundred thirteen alleles were detected all populations, with a mean 4.7 per locus. For chicken breeds, observed expected heterozygosity ranged 0.225 to 0.408...
DNA methylation in CpGs dinucleotides is associated with high mutability and disappearance of CpG sites during evolution. Although the thought to be relevant for vertebrate evolution, very little known on role CpG-related mutations genomic diversification vertebrates. Our study analysed genetic differences chickens, between Red Junglefowl (RJF; living closest relative ancestor domesticated chickens) breeds, identify dynamics that have occurred process their domestication, focusing...
The aim of this study was to identify breeding practices and trait preferences for indigenous sheep in three districts (Estie, Farta Lay Gayient) located the northwest highlands Ethiopia. Questionnaire survey choice experiment methods were used collect data from 370 smallholder farmers. Respondents selected randomly among farmers who own aforementioned districts. A generalized multinomial logit model employed examine attributes, while descriptive statistics index values computed describe...
Bone fracture in egg laying hens is a growing welfare and economic concern the industry. Although environmental conditions management (especially nutrition) can exacerbate it, primary cause of bone weakness resulting fractures believed to have genetic basis. To test this hypothesis, we performed genome-wide association study identify loci associated with strength hens. Genotype phenotype data were obtained from 752 belonging same pure line population. These genotyped for 580,961 SNPs,...
Native cattle breeds are important genetic resources given their adaptation to the local environment in which they bred. However, widespread use of commercial has resulted a marked reduction population size several native worldwide. Therefore, conservation management requires urgent attention avoid extinction. To this end, we genotyped nine Swedish with genome-wide 150 K single nucleotide polymorphisms (SNPs) investigate level diversity and relatedness between these breeds.We used various...
Copy number variation (CNV) is a major type of structural genomic that increasingly studied across different species for association with diseases and production traits. Established protocols experimental detection computational inference CNVs from SNP array next-generation sequencing data are available. We present the CNVRanger R/Bioconductor package which implements comprehensive toolbox structured downstream analysis CNVs. This includes functionality summarizing individual CNV calls...
In a previous study it was shown that nonsense mutation in the DMRT3 gene alters pattern of locomotion horses and this has strong positive impact on trotting performance Standardbreds. One aim to test if racing technique Nordic (Coldblood) trotters are also influenced by genotype. Another further investigate effect Standardbreds, using within-family analysis genotype-phenotype correlations larger horse material than study. We genotyped 427 621 Standardbreds for SNP linkage disequilibrium...
Abstract By studying genomic changes over time in populations subjected to strong artificial directional selection, we can gain insights the dynamics of beneficial alleles originating from founder population or emerging as novel mutations undergoing ongoing selection. The Virginia lines are a chicken resource generated by long-term bi-directional, single-trait selection for juvenile body weight. We studied genome-wide allele frequency generation 40 53 using genotypes and relaxed lines....
Abstract Background Native Swedish sheep breeds are part of the North European short-tailed group; characterized in by their genetic uniqueness. Our objective was to study population structure native sheep. Five were genotyped using 600 K SNP array. Dalapäls and Klövsjö from middle Sweden; Gotland Gute Gotland, an island Baltic Sea; Fjällnäs northern Sweden. We studied by: principal component analysis (PCA), cluster-based admixture, estimated tree. Results The analyses five revealed that...
The spectrum of modern horse populations encompasses with a long history development in isolation and relatively recently formed types. To increase our understanding the evolutionary provide information on how to optimally conserve or improve these varying background for future, we analyzed genotype data 184 horses from 9 Dutch common Netherlands: Belgian draft horse, Friesian Shetland pony, Icelandic Gelder Groninger harness KWPN sport Lipizzaner population. Various parameters were...
Gastrointestinal nematode (GIN) infections are one of the major constraints for grazing sheep and goat production worldwide. Genetic selection resistant animals is a promising control strategy. Whole-transcriptome analysis via RNA-sequencing (RNA-seq) provides knowledge mechanisms responsible complex traits such as resistance to GIN infections. In this study, we used RNA-seq monitor dynamics response abomasal mucosa Creole kids infected with Haemonchus contortus by comparing susceptible...
In the last decade, several studies aimed at dissecting genetic architecture of local small ruminant breeds to discover which variations are involved in process adaptation environmental conditions, a topic that has acquired priority due climate change. Considering traditional reservoir such important variation, improving current knowledge about their diversity and origin is first step forward designing sound conservation guidelines. The composition North-Western European archetypical goat...
Underutilized sheep and goat breeds can adapt to challenging environments due their genetics. Integrating publicly available genomic datasets with new data will facilitate genetic diversity analyses; however, this process is complicated by discrepancies, such as outdated assembly versions or different formats. Here, we present the SMARTER-database, a collection of tools scripts standardize metadata, mainly from SNP chip arrays on global small ruminant populations, focus reproducibility....
This study was initiated to identify the signalment and clinical variables potentially associated with hypomagnesemia in horses evaluated at North Carolina State University, College of Veterinary Medicine (NCSU-CVM) veterinary teaching hospital between January 1999 May 2001. A nested case reference (nested case-control study) conducted examine potential relationship signalment, serum chemistry panel analyses, number hospitalization days, discharge status, diagnosis. series independent...
Continuous rate infusion (CRI) of furosemide in humans is considered superior to intermittent administration (IA). This study examined whether CRI, compared with IA, would increase diuretic efficacy decreased fluid and electrolyte fluctuations activation the renin‐angiotensin‐aldosterone system (RAAS) horse. Five mares were used a crossover‐design study. During 24‐hour period, each horse received total 3 mg/kg by either CRI (0.12 mg/kg/h preceded loading dose 0.12 IV) or IA (1 IV q8h). There...
Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS1 gene. Conventional mutation detection techniques fail to detect a pathogenic approximately 50% of cases. The present study investigates whether large deletions are found families where gene have not been despite sequencing. For this purpose,a dense set SNP and microsatellite markers were used segregation analysis identify deletions. Large identified by technique three out eight investigated (38%)....