A5064758898- Genetic and phenotypic traits in livestock
- Gut microbiota and health
- Celiac Disease Research and Management
- Gastrointestinal motility and disorders
- Genetic diversity and population structure
- Microscopic Colitis
- Rangeland Management and Livestock Ecology
- Inflammatory Bowel Disease
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- RNA Research and Splicing
- Helicobacter pylori-related gastroenterology studies
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Diet and metabolism studies
- Metallurgy and Material Forming
- Microbial Metabolites in Food Biotechnology
- Data Mining Algorithms and Applications
- Eating Disorders and Behaviors
- Biochemical and Structural Characterization
- Healthcare Technology and Patient Monitoring
- Software Reliability and Analysis Research
- Infant Health and Development
- Eosinophilic Esophagitis
- Software Engineering Techniques and Practices
McMaster University
2015-2025
Uppsala University
2021-2024
Institut de Biologia Evolutiva
2023
Population Health Research Institute
2015-2022
Universidade do Porto
2008-2021
Technical University of Denmark
2018-2019
Instituto de Biologia Experimental e Tecnológica
2003
Fecal microbiota transplants from patients with irritable bowel syndrome and anxiety alter gut function behavior in germ-free mice.
Changes in hygiene and dietary habits, including increased consumption of foods high fat, simple sugars, salt that are known to impact the composition function intestinal microbiota, may explain increase prevalence chronic inflammatory diseases. High has been shown worsen autoimmune encephalomyelitis colitis mouse models through p38/MAPK signaling pathway. However, effect diet (HSD) on gut microbiota immune homeostasis, their roles determining vulnerability stimuli unknown. Here, we...
Abstract Sheep are among the earliest domesticated livestock species, with a wide variety of breeds present today. However, it remains unclear how far back this diversity goes, formal documentation only dating few centuries. North European short-tailed (NEST) often assumed to be oldest domestic sheep populations, even thought represent relicts expansions during Neolithic period reaching Scandinavia <6,000 years ago. This study sequenced genomes (up 11.6X) five from Baltic islands...
Abstract Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication took place Southwest Asia, although much remains unresolved about precise location(s) and timing(s) earliest domestication, or post-domestication history sheep. Here, we present 24 new partial sheep paleogenomes, including a 13,000-year-old Epipaleolithic Central Anatolian wild sheep, as well 14 domestic from Anatolia, two Iran, Iberia, three France,...
Abstract Background Lifestyle factors like diet, physical activity, and sleep patterns are known to influence symptoms progression in Inflammatory Bowel Disease (IBD). However, accurately determining temporal relationships between these has been hampered by a lack of reliable data collection methods. New technologies, such as wearables smartphone apps, offer real-time, remote monitoring allow for better understanding their relationship with IBD symptoms. Aims To assess the feasibility using...
Abstract Background Diet is a key influence on symptoms and disease activity in IBD patients, but effective dietary intervention relies patient adherence, which often sub-optimal clinical practice research. Adherence shaped by individual barriers, beliefs behaviours that must be addressed when recommending personalized interventions, these barriers are not well understood for patients. Aims To identify patients’ self-identified to modification understand their experiences expectations...
Abstract Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central west Anatolian sheep dating Epipaleolithic to late Neolithic, comparatively with modern-day breeds Asian Neolithic/Bronze Age (OBI). Analyzing data, found that Neolithic (ANS) are genetically closest present-day European relative breeds, a conclusion supported by mtDNA haplogroup frequencies. In...
Once widespread in their homelands, the Anatolian mouflon (Ovis gmelini anatolica) and Cyprian ophion) were driven to near extinction during 20th century are currently listed as endangered populations by International Union for Conservation of Nature. While exact origins these lineages remain unclear, they have been suggested be close relatives domestic sheep or remnants proto-domestic sheep. Here, we study whole genome sequences n = 5 mouflons 10 terms population history diversity,...
As one of the earliest livestock, sheep (Ovis aries) were domesticated in Fertile Crescent about 12,000-10,000 years ago and have a nearly worldwide distribution today. Most our knowledge timing their expansions stems from archaeological data but it is unclear how genetic diversity modern fits with these dates. We used whole-genome sequencing 63 domestic breeds wild relatives, Asiatic mouflon (O. gmelini, previously known as O. orientalis), to explore demographic history sheep. On global...
Abstract Background Many patients living with IBD identify diet as a key factor in managing their disease, symptoms and general health, many report implementing dietary restrictions response to disease activity symptoms. Despite increasing data on the role of diet, face variety challenges that can compromise adherence recommendations clinical practice. Aims To patients’ perceptions regarding barriers modification understand experiences expectations advice from gastroenterologists (GI) or...
Abstract Sheep are among the earliest domesticated livestock species, with a wide variety of breeds present today. However, it remains unclear how far back this breed diversity goes, formal documentation only dating few centuries. North European short-tailed often assumed to be oldest domestic sheep populations, even thought represent relicts expansions during Neolithic period reaching Scandinavia less than 6000 years ago. This study sequenced genomes (up 11.6X) five from Baltic islands...
<ns4:p><ns4:bold>Background:</ns4:bold> Inflammatory bowel disease (IBD) is a group of chronic diseases related to inflammatory processes in the digestive tract generally associated with an immune response altered gut microbiome genetically predisposed subjects. For years, both researchers and clinicians have been reporting increased rates anxiety depression disorders IBD, these also linked microbiome. However, underlying pathophysiological mechanisms comorbidity are poorly understood at...
This work presents the improvement of a software for clinical setup, Anesthesia Synchronization Software (ASYS). The first version presented data acquisition from cerebral monitors and partial control with Target Controlled Infusion (TCI) system. Based on pharmacokinetic models, effect-site plasma concentrations can be related drug dose infused vice versa. later comes implementation hemodynamic monitor always present in operating rooms full TCI system developed to determine infusion rates...
<ns4:p><ns4:bold>Background:</ns4:bold> Inflammatory bowel disease (IBD) is a group of chronic diseases related to inflammatory processes in the digestive tract generally associated with an immune response altered gut microbiome genetically predisposed subjects. For years, both researchers and clinicians have been reporting increased rates anxiety depression disorders IBD, these also linked microbiome. However, underlying pathophysiological mechanisms comorbidity are poorly understood at...
Abstract Background Patients with self-perceived gluten sensitivity often undergo double-blinded, placebo-controlled (DBPC) challenge studies to determine whether or wheat trigger their symptoms. However, it is unknown the result disclosure impacts patients’ beliefs and dietary choices. Aims To evaluate impact of disclosing results DBPC on choices in IBS patients who adopt a gluten-free diet (GFD). Methods We conducted crossover trial 28 adult (Rome IV) previously reported improvement...
Abstract Background Stressful events in childhood have been associated with the development of functional gastrointestinal (GI) disorders adulthood, especially irritable bowel syndrome. The influence early life adverse patients common organic disorders, such as celiac disease and inflammatory (IBD), has poorly investigated. Aims To evaluate frequency compared to healthy controls. Methods Adult an established diagnosis IBS (Rome IV criteria), (IBD) attending a tertiary medical center, well...
Forecasts of the effort or delivery date can play an important role in managing software projects, but estimates provided by development teams are often inaccurate and time-consuming to produce. This is not surprising given uncertainty that underlies this activity. work studies use Monte Carlo simulations for generating forecasts based on project historical data. We have designed run experiments comparing these against what happened practice developers, when available. Comparisons were made...