A5102891411- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- RNA regulation and disease
- Circular RNAs in diseases
- Apelin-related biomedical research
- Diet and metabolism studies
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Adipose Tissue and Metabolism
- Cardiac Arrest and Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vitamin D Research Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Hepatitis C virus research
- Nutritional Studies and Diet
- RNA modifications and cancer
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Telomeres, Telomerase, and Senescence
Central South University
2018-2024
Second Xiangya Hospital of Central South University
2018-2024
Taizhou People's Hospital
2024
Nanjing Medical University
2024
Nantong University
2024
Xiangya Hospital Central South University
2020
Vitamin D deficiency (VDD) increases the risk for type 2 diabetes mellitus (T2DM), which might be related to insulin resistance (IR). We aimed explore association between triglyceride-glucose (TyG) index, a reliable indicator of IR, and VDD in patients with T2DM.There were 1034 participants T2DM enrolled Second Xiangya Hospital Central South University. The TyG index was calculated as ln (fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2). defined 25-hydroxyvitamin [25(OH)D]...
Abstract Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory molecules involved in diverse biological processes. Our previous study demonstrated that lncRNA‐ES3 is associated with the high glucose–induced calcification/senescence of human aortic vascular smooth muscle cells (HA‐VSMCs). However, mechanism calcification/aging remained largely unknown. Here, we report expression basic helix‐loop‐helix family member e40 (Bhlhe40) was decreased significantly HA‐VSMCs treated...
Background: Postinfarction ventricular septal rupture (PI-VSR) is a rare but devastating complication of acute myocardial infarction (AMI). Risk stratification in the phase crucial for decision-making, and this study analyzed risk factors early mortality effects various management options on outcome PI-VSR patients era percutaneous intervention. Methods: A total 96 with were identified divided into an acute-phase survivor group (n = 46, survived ≥2 weeks after admission) nonsurvivor 50, died...
Abstract Objective Cardiovascular diseases and vascular aging are common in patients with diabetes. High glucose is a major cause of cardiovascular diseases. Premature senescence smooth muscle cells (VSMCs) one the main contributors to aging. Adiponectin has been demonstrated have an anti‐aging effect. The present study explored mechanisms by which adiponectin protects VSMCs against high‐glucose‐induced senescence. Methods Senescence‐associated β‐galactosidase (SA‐β‐gal) staining was used...
To construct an individualized nomogram prediction model for predicting the risk of occurrence covert hepatic encephalopathy (CHE) in patients with liver cirrhosis.
We are pleased to see that Mahat and Rathore [...]
Alzheimer's Disease (AD) is the most prevalent, costly, and fatal neurodegenerative disorder of this century. Two hallmark features AD are anomalous cleavage amyloid precursor protein (APP), which leads to accumulation amyloid-beta (Aβ), hyperphosphorylation tau protein. Despite extensive research efforts, pathology pathogenesis remain elusive. Recent investigations have highlighted close association between antisense long non-coding RNAs (AS-lncRNAs) various biological functional aspects...
Vascular calcification and aging often increase morbidity mortality in patients with diabetes mellitus (DM); however, the underlying mechanisms are still unknown. In present study, we found that Bcl-2 modifying factor (BMF) BMF antisense RNA 1 (BMF-AS1) were significantly increased high glucose-induced calcified senescent vascular smooth muscle cells (VSMCs) as well artery tissues from diabetic mice. Inhibition of BMF-AS1 reduced senescence VSMCs, whereas overexpression generates opposite...
Abstract Long noncoding RNAs (lncRNAs) are emerging regulators of vascular diseases, yet their role in diabetic calcification/aging remains poorly understood. In this study, we identified a down-expressed lncRNA SNHG1 high glucose (HG)-induced smooth muscle cells (HA-VSMCs), which induced excessive autophagy and promoted HA-VSMCs calcification/senescence. Overexpression alleviated HG-induced The molecular mechanisms calcification/senescence were explored by RNA pull-down,...
Obesity causes an imbalance in the expression and secretion of several organokines, which turn contributes to development metabolic disorders such as type 2 diabetes mellitus. Organokines are produced by corresponding organs affect systemic homeostasis. Diverse organokines play a crucial role communication between adipose tissue, skeletal muscle other organs. In this review, we discuss biological properties specific adipokines, hepatokines, myokines. We also highlight cumulative roles...
Objective: To assess the clinical characteristics and identify risk factors in acute myocardial infarction (AMI) patients complicating with ventricular septal rupture (VSR). Methods: A retrospective study was performed on 96 AMI VSR, who were hospitalized Second Xiangya Hospital of Central South University, Hunan Provincial Peoples' Hospital, First Affiliated University China, hospital south Xiangtan from December 2007 to May 2017. There 46 females age (66.2±10.7) years (from 43 90 years)....
Abstract Vascular calcification/aging is a crucial feature of diabetic macro vasculopathy, resulting in serious cardiovascular diseases. The calcification/senescence vascular smooth muscle cells (VSMCs) induced by hyperglycemia can cause calcification/aging. However, the mechanism VSMCs involved remains unknown. purpose this study was to determine how high glucose (HG) information circulating blood transmitted from endothelial (ECs) VSMCs, which are not contacted with directly. Exosomes have...
Abstract Objective To investigate the relationship between icariin and osteoblastic differentiation of vascular smooth muscle cells (VSMCs) signal pathway involved. Methods We applied a universally accepted calcification model VSMCs induced by β glycerophosphate. Then was observed treatment with and/or inhibitors estrogen receptors (ERs) p38‐mitogen‐activated protein kinase (MAPK) signaling. Results Icariin inhibited mineralization due to decreased ALP activity Runx2 expression. Further...