A5100646853- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Frailty in Older Adults
- Obstructive Sleep Apnea Research
- Body Composition Measurement Techniques
- Diabetes Management and Research
- Health and Wellbeing Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Nutritional Studies and Diet
- Menopause: Health Impacts and Treatments
- Urban Green Space and Health
- Peroxisome Proliferator-Activated Receptors
Kunming Medical University
2021-2025
Second Xiangya Hospital of Central South University
2009-2024
Central South University
2007-2024
Tsinghua University
2022
First People's Hospital of Yunnan Province
2022
Harbin Medical University
2017-2018
Xiangya Hospital Central South University
2007-2014
The aim was to apply AWGS criteria estimate the prevalence of sarco-osteoporosis and investigate its relationship with frailty, in a sample 316 community-dwelling Chinese older people. Regression analysis performed using frailty as dependent variable. results showed that rate 10.4% men 15.1% women. ≧80 years old (OR 4.8; 95% CI, 3.05–10.76;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.027</mml:mn></mml:math>), women 2.6;...
OBJECTIVE We aimed to evaluate whether xanthine oxidase (XO), a key enzyme in uric acid (UA) metabolism and major source of reactive oxygen species, plays causal important role the development type 2 diabetes mellitus (T2DM) large prospective cohort study. RESEARCH DESIGN AND METHODS A total 4,412 diabetes-free adults (2,071 women 2,341 men) aged 30–65 years at baseline 2008 were involved. Participants followed for incident change glucose during an average 4.7 years. At baseline, serum XO...
Vitamin D deficiency (VDD) increases the risk for type 2 diabetes mellitus (T2DM), which might be related to insulin resistance (IR). We aimed explore association between triglyceride-glucose (TyG) index, a reliable indicator of IR, and VDD in patients with T2DM.There were 1034 participants T2DM enrolled Second Xiangya Hospital Central South University. The TyG index was calculated as ln (fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2). defined 25-hydroxyvitamin [25(OH)D]...
Arterial calcification is an important pathological change of diabetic vascular complication. Osteoblastic differentiation smooth muscle cells (VSMCs) plays cytopathologic role in arterial calcification. The glucagon-like peptide-1 receptor agonists (GLP-1RA), a novel type antidiabetic drugs, exert cardioprotective effects through the GLP-1 (GLP-1R). However, question whether or not GLP-1RA regulates osteoblastic and VSMCs has been answered, associated molecular mechanisms have examined....
Background/Aims: Atherosclerosis is the primary cause of cardiovascular ischaemic events; arterial stiffness a characteristic atherosclerotic process. MicroRNAs (miRNAs) have been revealed as crucial modulators atherosclerosis. However, role stiffness-related miRNAs in process still unclear. Methods: Four hundred six participants from Northern China were enrolled this study. Circulating miR-1185 and adhesion molecule levels measured. Multiple linear regression models used to evaluate...
To determine the association of physical activity (PA) and sedentary time (ST; leisure total ST), commuting mode with hyperuricemia in a multiethnic Chinese population, to analyze difference between sexes.Baseline data were analyzed from 22,094 participants China Multi-Ethnic Cohort study Yunnan region, China. PA behavior assessed through questionnaires. Hyperuricemia was defined as serum urate > 7.0 mg/dL among men 6.0 women. A restricted cubic spline (RCS) created model possible nonlinear...
Abstract Context Loss of sleep or disturbance sleep-wake cycles has been related to metabolic impairments. However, few studies have investigated the association between daily duration and hyperuricemia. Objective We (daytime napping nocturnal sleep) with hyperuricemia risk. Methods cross-sectionally analyzed data from China Multi-Ethnic Cohort (CMEC), Yunnan region. A total 22 038 participants aged 30 79 years were recruited in 2018. Hyperuricemia was defined as serum uric acid (SUA) above...
Vitamin D binding protein (DBP) may alter the biologic activity of 25-hydroxyvitamin [25(OH)D]. The objective our present study was to determine joint effect serum 25(OH)D and DBP on risk frailty. Five hundred sixteen male participants aged 70 years or older were recruited in Changsha city its surrounding area Hunan province China. Frailty defined as presence at least three five following criteria: weakness, low physical activity, slow walking speed, exhaustion, weight loss. Multivariate...
Type 2 diabetes accounts for about 90% of patients, and the incidence is on rise as people’s lifestyles change. Compared with GLP-1 treatment, probiotic treatment can directly regulate homeostasis host gut microbe, thus its metabolites. Currently, regulatory role probiotics intestinal metabolites after type mellitus remains unclear. The purpose this study was to investigate therapeutic effect short-chain fatty acids, which are microorganisms. I collected feces from 15 patients before...
Sarcopenia was recently reported to be relevant an increased macro-and microvascular disease risk. index (SI) has been identified as a surrogate marker for sarcopenia. The aim of the present study investigate association between macro- and SI in patients with type 2 diabetes mellitus (T2DM). A total 783 T2DM were enrolled this cross-sectional study. calculated by (serum creatinine [mg/dL]/cystatin C [mg/L]) × 100. subjects divided into three groups according tertiles: T1 (41.27–81.37), T2...
We are pleased to see that Mahat and Rathore [...]
Experimental evidence suggests saturated fatty acids (SFAs) are associated with insulin resistance, but results from epidemiological studies on fasting SFAs-diabetes risk inconsistent. We investigated SFA (fasting and 2-hour postprandial) profiles diabetes risk. A total of 8940 participants were recruited for the Harbin People’s Health Study in 2008. Serum SFAs at baseline Chinese men women without profiled, type 2 was ascertained using World Organization criteria after 4 to 7 years...
Background: Previous studies suggested protective effects of bilirubin against cardiovascular disease, with a possible gender difference. However, the relationship between serum total (TBIL) diabetic macro- and microvascular complications remains unknown. We aimed to examine association TBIL levels. Methods: Serum was measured in 648 patients T2DM. Demographic clinical data were obtained from inpatient medical record system. an automatic biochemistry analyzer according routine protocols....
Abstract Objective Life’s Essential 8 (LE8) is a new comprehensive metric based on Simple 7 (LS7). Few studies have investigated the association between LE8 and odds of hyperuricaemia (HUA). This study examined LE8, LS7 with HUA. Methods We cross-sectionally analysed data from China Multi-Ethnic Cohort (CMEC) study. were categorized as low, moderate high. The CMEC provided an ideal unique opportunity to characterize Results Of 89 823 participants, 14 562 (16.2%) had A high level was...
To assess the effect of Klotho gene transduction on progression hypertension and heart damage in spontaneous hypertensive rats (SHRs).An adeno-associated virus (AAV) carrying full-length mouse cDNA (rAAV.mKL) was constructed for vivo expression Klotho. Three different groups male SHRs a control group sex age-matched Sprague Dawley (SD) (5 per group) were used. The experimental received an IV injection phosphate buffered saline (PBS), rAAV.mKL rAAV.EGFP, respectively. only equal-volume PBS....
The relationship between renal function and bone mineral density (BMD) is controversial. aim of this study was to determine the with BMD osteoporosis risk in healthy postmenopausal Chinese women.A cross-sectional conducted 776 women. Dual-energy X-ray absorptiometry used measure BMDs. Clinical, demographic, biochemical data were obtained at time image acquisition. Estimated glomerular filtration rate (eGFR) calculated using a Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)...
<title>Abstract</title> Background Nutritional status is a malleable determinant of body composition abnormalities, including obesity, sarcopenia, and sarcopenic obesity (SO). Here, we evaluated the prevalence these abnormalities in older Chinese inpatients explored their correlations with patients’ nutritional status. Methods In total, 451 aged ≥ 65 years admitted to Second Xiangya Hospital Central South University were included. An algorithm proposed by Asian Working Group for Sarcopenia...
Previous studies have yielded inconsistent findings regarding the association between age at menopause and bone health, with limited exploration of potential mediating factors, particularly in less-developed muti-ethnic regions China. Our objective was to analyze health among postmenopausal women southwest China, while also examining effect body mass index (BMI) moderating years since on this association. The analysis included a total 15,352 naturally obtained from baseline data China...