A5071327496- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Redox biology and oxidative stress
- Circular RNAs in diseases
- Alcohol Consumption and Health Effects
- Innovations in Medical Education
- Gout, Hyperuricemia, Uric Acid
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- TGF-β signaling in diseases
- Interprofessional Education and Collaboration
- Berberine and alkaloids research
- Bone Metabolism and Diseases
- Nutritional Studies and Diet
- Educational Reforms and Innovations
- Genetics, Aging, and Longevity in Model Organisms
- Medical Research and Treatments
- Free Radicals and Antioxidants
- Liver Disease Diagnosis and Treatment
- Sleep and related disorders
- E-Learning and COVID-19
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
Kunming Medical University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
University of Kentucky
2013-2022
Third Hospital of Nanchang
2021
Nanchang University
2021
Northwestern Polytechnical University
2019-2020
Xuzhou Medical College
2020
Second People’s Hospital of Huai’an
2020
Second Affiliated Hospital of Zhejiang University
2020
Affiliated Hospital of Hebei University
2018-2019
Glioblastoma multiforme (GBM) is an aggressive brain tumour which drug treatment has no overall significant effect on survival rate. Sinomenine a natural product extracted from the traditional Chinese medicine Qingteng and was found to have certain anti-tumour effect. Although, its short biological half-life, unstable physicochemical properties, large dosage causes histamine release hindered use but it may form basis for novel therapy of GBM. We designed, synthesised screened sinomenine...
Advanced and recurrent ovarian cancer has a poor prognosis is frequently resistant to numerous therapeutics; thus, safe effective drugs are needed combat this disease. Previous studies have demonstrated that triptolide (TPL) exhibits anticancer sensitization effects against cisplatin (DDP)‑resistant both in vitro vivo by inducing apoptosis; however, the involvement of autophagy induced TPL carcinoma remains unclear. In present study, results revealed facilitate SKOV3/DDP cell death. The...
Angiogenesis is a crucial event during cancer progression that regulates tumor growth and metastasis. Activin receptor-like kinase 1 (ALK1), predominantly expressed in endothelial cells, plays key role the organization of neo-angiogenic vessels. Therapeutic targeting ALK1 has been proposed as promising strategy for treatment, microRNAs (miRNAs) are increasingly being explored modulators angiogenesis. However, regulation by miRNAs unclear. In this study, we identified directly targeted...
Practical teaching is vital for preparing public health students to address real-world challenges. This study evaluates the impact of open collaborative practical reforms on student satisfaction compared traditional approaches. A validated Likert scale-based questionnaire assessed among 188 (96 Reform Group; 92 Traditional Group). Reliability (Cronbach's α = 0.987) and validity (KMO 0.948; p < 0.001) tests confirmed instrument's robustness. Comparative analyses examined across methods,...
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild agents will sensitize radiation, this may also activate the adaptive defense system in cells. Ascorbic acid is a prototype redox modulator when infused intravenously appears kill cancers without injury tissues; however, mechanisms involved remain elusive. In study, we show how ascorbic kills and sensitizes prostate...
MicroRNA-575 (miR-575) is oncogene in many tumors. However, the role of miR-575 progression gastric cancer (GC) still unknown. The aim this study was to identify whether play a development GC. We obtained GC cell lines, tissues from 40 patients measure levels and its predicted target PTEN by using RT‑PCR, immunohistochemistry or western blot analysis. MGC-803 cells were transfected with inhibitor, viability apoptosis measured. aberrantly up-regulated lines compared corresponding control. In...
To determine the association of physical activity (PA) and sedentary time (ST; leisure total ST), commuting mode with hyperuricemia in a multiethnic Chinese population, to analyze difference between sexes.Baseline data were analyzed from 22,094 participants China Multi-Ethnic Cohort study Yunnan region, China. PA behavior assessed through questionnaires. Hyperuricemia was defined as serum urate > 7.0 mg/dL among men 6.0 women. A restricted cubic spline (RCS) created model possible nonlinear...
Abstract Context Loss of sleep or disturbance sleep-wake cycles has been related to metabolic impairments. However, few studies have investigated the association between daily duration and hyperuricemia. Objective We (daytime napping nocturnal sleep) with hyperuricemia risk. Methods cross-sectionally analyzed data from China Multi-Ethnic Cohort (CMEC), Yunnan region. A total 22 038 participants aged 30 79 years were recruited in 2018. Hyperuricemia was defined as serum uric acid (SUA) above...
Abstract Dysregulation of circRNAs is reported to exert crucial roles in cancers, including hepatocellular carcinoma (HCC). So far, the function HCC development remains poorly known. Currently, our data showed that circ_0008305 was highly elevated cell lines and 30 paired tissue samples HCC. As evidenced, suppression repressed growth significantly. Meanwhile, up‐regulation significantly reduced growth. Mechanistically, we displayed could bind with miR‐186 by using bioinformatics analysis....
Purpose: The aim of this study was to explore the mechanism neurological changes underlying toxicity nicotine.Materials and methods: Rat pheochromocytoma 12 (PC12) cells human neuroglia (HM) were used. ROS levels detected by FACScan. Autophagy flux monitored a tandem monomeric RFP-GFP-tagged LC3 lentivirus. autophagic proteins LC3, SQSTM1/p62 Beclin1 western blot assay. In order evaluate effects nicotine melatonin on morphological neurons, primary cortical neurons obtained...
Objectives Several studies have demonstrated the association between gamma-glutamyl transferase (GGT) and hyperuricaemia, but little is known about such relation in less-developed ethnic minority regions. Design We cross-sectionally analysed data from China Multi-Ethnic Cohort (Yunnan region). Setting Cross-sectional study. Participants 22 020 participants aged 30–79 years Han ethnicity, Yi ethnicity Bai ethnicity. Outcomes The serum level of uric acid, GGT other metabolic parameters were...
Aim: Family function affects college students’ psychotic experience and what behaviors they have or produced in daily life, the corresponding effects of these behaviors. Through problems reflected research institute, to create a family environment suitable for physical mental health students, provide reference prevention illness, promote healthy growth comprehensive development lay foundation. Methods: functioning was assessed by Function Rating Scale (FAD) experiences were investigated 715...
<title>Abstract</title> Objective After the implementation of a series open practice teaching reform measures, satisfaction health inspection and quarantine students with practical was investigated. Method A self-designed Likert scale used to survey 110 regarding their teaching. Results The <italic>Cronbach’s α</italic> reliability coefficient 0.987, Kaiser-Meyer-Olkin (<italic>KMO</italic>) value 0.921. Among 8 core courses in major, scores pertaining epidemiology were highest terms...
To address gaps in practical skills among Public Health and Preventive Medicine graduates, an ‘open collaborative practice teaching model’ integrating medicine, teaching, research was introduced. A cross-sectional study surveyed 312 undergraduates at a Yunnan medical university from 2020 to 2023, utilizing satisfaction scores analyses (cluster, factor, SWOT) assess the impact of reform. Satisfaction baseline, mid-term, end-term assessments showed minor variations (4.30, 4.29, 4.36), with...
Abstract Objective To address the inadequacy of practical work skills among graduates in Public Health and Preventive Medicine, this study implemented an innovative "open collaborative practice teaching model integrating medicine, teaching, research." It analyzed changes student satisfaction before after three years reform, offering strategic suggestions aimed at strengthening vocational future public health workers through reform teaching. Methods A cross-sectional was conducted from 2020...
Objective: To observe the changes of LHX4 and DIS3L mRNA protein expression in Nthy-ori-3-1 cells after treatment thyroid disruptor p, p'-DDE. Methods: logarithmic growth phase were treated with 0, 0.5, 1.0, 2.0 5.0 μg/ml p'-DDE solution. The state morphology observed by microscope. levels detected real-time fluorescent quantitative PCR, Western blot. Results: when concentrations 1.0 μg/ml, grew normally. There 33 differential genes group, among which 13 down regulated 20 up-regulated....